937 research outputs found
Proceedings of ASME Turbo Expo 2013: Power for Land, Sea and Air, Volume 1A: Combustion, Fuels and Emissions
No full textShahrokh Etemad (with Sandeep Alavandi and Benjamin Baird) is a contributing author, Fuel Flexible Rich Catalytic Lean Burn System for Low Btu Fuels
PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development
No full textCD68+ tumor-associated macrophages (TAMs) are pro-tumorigenic, pro-angiogenic and are associated with decreased survival rates in patients with cancer, including breast cancer. Non-specific models of macrophage ablation reduce the number of TAMs and limit the development of mammary tumors. However, the lack of specificity and side effects associated with these models compromise their reliability. We hypothesized that specific and controlled macrophage depletion would provide precise data on the effects of reducing TAM numbers on tumor development. In this study, the MacLow mouse model of doxycycline-inducible and selective CD68+ macrophage depletion was crossed with the murine mammary tumor virus (MMTV)-Polyoma virus middle T antigen (PyMT) mouse model of spontaneous ductal breast adenocarcinoma to generate the PyMT-MacLow line. In doxycycline-treated PyMT-MacLow mice, macrophage numbers were decreased in areas surrounding tumors by 43%. Reducing the number of macrophages by this level delayed tumor progression, generated less proliferative tumors, decreased the vascularization of carcinomas and down-regulated the expression of many pro-angiogenic genes. These results demonstrate that depleting CD68+ macrophages in an inducible and selective manner delays the development of mammary tumors and that the PyMT-MacLow model is a useful and unique tool for studying the role of TAMs in breast cancer
Health Ministry's Screening Committee (Indian Council of Medical Research)
No full textThe Health Ministry's Screening Committee (Indian Council of Medical Research) takes decisions on the international research proposals in the field of health research, requiring foreign collaboration and assistance from foreign funding agencies
Conference news
No full textIn this edition of conference news, we round up on conferences on heart failure in India. The Cardiology Society of India held its first conference on heart failure in Indore. The Heart Failure Association of India held its meeting in Delhi. AIIMS, JNU and the Journal of the Practice of Cardiovascular Sciences will conduct the Heart Failure Certification Program in October in JNU
Higher Himalayan Crystalline (HHC) Belt: its shear sense indicators and their implications on its tectonic evolution
No full textThe Hriday Card: A checklist for heart failure
No full textUse of a simple checklist can drastically lower the likelihood of heart failure patient readmission and improve quality of life. The Hriday Card is a simple 4 page booklet which combines patient education material teaching the patient about heart failure, how to tackle daily emergencies, how to look after their fluid balance with appropriate use of diuretics. It also contains medication and daily weight charts for the patient and a heart failure checklist for the heart failure nurse or doctor which covers points like vaccination, presence of LBBB or Atrial fibrillation and use or lack of use of ACE inhibitors and beta blockers and many other points related to heart failure. This checklist can be filled in less than a minute. It is a simple tool to enhance heart failure care and medication adherence
A case of cardiomyopathy: Systemic congestion with minimum clinical features
No full textA patient with systemic congestion, jaundice and pedal edema is presented and the clinical approached is discussed. The clinical findings, along with the ECG, Chest xray and Echocardiogram are used to arrive at a diagnosis. A brief description of some of the conditions including restrictive cardiomyopathy, constrictive pericarditis, amyloid etc are discussed. The differential diagnosis at each stage of presentation i.e. history and examination are presented and discussed
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