53 research outputs found
At the Origins of the Reflective–Activity Approach: to the 120th Anniversary of Piotr Yakovlevich Galperin, to the 90th Anniversary of Nikita Glebovich Alekseev
No full textThe article is dedicated to the memory of the author's teachers in psychology, written in connection with the anniversaries of the outstanding Russian psychologists P.Ya. Galperin and N.G. Alekseev. Both scientists are the authors of the ideas underlying the reflective–activity approach (RAA) to assist students in overcoming learning difficulties, developed by the author. In 2022, practicians of the RAA celebrate 25 years since the birth of the approach, and this event prompts the author to turn to the origins of its occurrence, to the ideas on the basis of which the RAA technology is built. P.Ya. Galperin's ideas on internalization and the formation of mental actions are combined with N.G. Alekseev's ideas on reflection and reflective thinking based on the basic principles of cultural–historical psychology developed by L.S. Vygotskii. As a basis for uniting the ideas of L.S. Vygotskii, P.Ya. Galperin and N.G. Alekseev, their attitude to psychological practice becomes. The implementation of these ideas within the framework of the RAA is briefly considered on the example of three projects: summer schools, chess for general development, assistance to orphans with disabilities and severe somatic diseases.</p
Zone of Proximal Development: Evolution of the Concept
No full textThe main idea of the article is to trace the development and use of the concept of zone of proximal development (ZPD) in the works of Russian psychologists since its introduction into the conceptual apparatus of cultural-historical psychology by L.S. Vygotsky. The article consists of three parts. The first is devoted to the definition of the concept of ZPD, in which the contradictions between the ideas of the author of the concept and the interpretations of it by other authors are analyzed. The “classical definition” of ZPD is supplemented by the ideas of L.S. Vygotsky, expressed by him in other works. The other two parts of the article are devoted to changes in the methodological functions of the concept at different stages of its development: from an explanatory principle to the subject of research, and from the subject of research to a methodological means for the construction of new subjects of practice-oriented technologies. The general trend is to expand the areas of application of the ZPD concept, to go beyond the initial tasks of explaining and theoretically justifying the special connection between learning and development, and beyond the problems of interaction between a child and an adult. Particular attention is paid to the helping activity of an adult (teacher, psychologist, parent, etc.): the main question is how to help in order to contribute to the development. It is shown that the concept of ZPD is now used in psychotherapy and practice of working with adults with developmental disorders, i.e. it becomes the link between education (learning), development and mental health.</p
Disrupted Ugi Reaction: Synthesis of Cyclic Peptides and Peptidomimetics
No full textCyclization is a technique often employed in the design of therapeutic agents and molecular probes to increase a molecule's affinity and selectivity towards enzyme or receptor target. Recent efforts have yielded a new method of piperazinone formation and peptide cyclization using unprotected aziridine aldehydes. The counterintuitive combination of a nucleophile and an electrophile in one molecule facilitates stitching of amino acids or linear peptides at high concentrations, thereby reducing reaction times. The scope of this reaction has been investigated with a variety of amino acids and peptides. The results differ from the initial studies and a new mechanism has been proposed that takes into account the substrate-dependent reactivity and formation of side-products. A variety of functionalization reactions, through aziridine ring-opening, have been reported. The ring-opened products have exhibited unique structural properties which have been investigated by ab initio calculations, X-ray crystallography, and NMR spectroscopy. Finally, the elements of scaffold design and aziridine ring-opening chemistry have been applied to the creation of inhibitors for Calpain, a disease-causing protease.Ph.D.2017-06-30 00:00:0
Disrupted Ugi Reaction: Synthesis of Cyclic Peptides and Peptidomimetics
No full textCyclization is a technique often employed in the design of therapeutic agents and molecular probes to increase a molecule's affinity and selectivity towards enzyme or receptor target. Recent efforts have yielded a new method of piperazinone formation and peptide cyclization using unprotected aziridine aldehydes. The counterintuitive combination of a nucleophile and an electrophile in one molecule facilitates stitching of amino acids or linear peptides at high concentrations, thereby reducing reaction times. The scope of this reaction has been investigated with a variety of amino acids and peptides. The results differ from the initial studies and a new mechanism has been proposed that takes into account the substrate-dependent reactivity and formation of side-products. A variety of functionalization reactions, through aziridine ring-opening, have been reported. The ring-opened products have exhibited unique structural properties which have been investigated by ab initio calculations, X-ray crystallography, and NMR spectroscopy. Finally, the elements of scaffold design and aziridine ring-opening chemistry have been applied to the creation of inhibitors for Calpain, a disease-causing protease.Ph.D.2017-06-30 00:00:0
Synthesis of Peptidomimetics Through the Disrupted Ugi Reaction with Aziridine Aldehyde Dimers
No full text
Current Cases and Issues: A Roundtable Discussion
No full textJane Levine: This is the last panel of the day, and I should first thank all of you for coming and especially for staying until the end of the day. This is going to be a roundtable panel. I am hoping to engage the panelists in a discussion rather than sequential presentations. I am Jane Levine and I am currently the Director of Compliance at Sotheby’s. Before I came to Sotheby’s, I was at the U.S. Attorney’s Office in the Southern District of New York, where I worked on a lot of different kinds of art crime matters, including forgery cases. I have the pleasure of having this great panel of lawyers talk about some of the issues we’ve touched on today and some new ones. I am going to introduce them now. To my immediate left is Jo Laird who is now of counsel at Patterson Belknap. Jo has a varied practice in all kinds of art law matters, representing collectors, museums, galleries and dealers. She was, prior to joining Patterson Belknap, the General Counsel of Christie’s, Inc., which is how I first met her because in my previous job at the U.S. Attorney’s office we had a lot of dealings with one another. So, I know Jo to be an expert on many matters of art law. She is also a Columbia Law School graduate-so we are really happy to have her here. To her left is Michael Salzman who is the co-head of the art law practice at Hughes Hubbard & Reed and also known to many of you in the room as an art lawyer with a lot of experience in a lot of different cases. Last is Donn Zaretsky, who is actually an alumni of Paul, Weiss-another thing we have in common-but now with John Silberman Associates where he has an art law and entertainment practice. Donn represents a lot of artists and I am hoping that that is one perspective we can bring out today. In addition, Donn is the author of the Art Law Blog, which-if you are not familiar with it-you should check out. It is a really wonderful blog and resource and worth reading
Recommended from our members
A Current Cases and Issues: A Roundtable Discussion
No full textJane Levine: This is the last panel of the day, and I should first thank all of you for coming and especially for staying until the end of the day. This is going to be a roundtable panel. I am hoping to engage the panelists in a discussion rather than sequential presentations. I am Jane Levine and I am currently the Director of Compliance at Sotheby’s. Before I came to Sotheby’s, I was at the U.S. Attorney’s Office in the Southern District of New York, where I worked on a lot of different kinds of art crime matters, including forgery cases. I have the pleasure of having this great panel of lawyers talk about some of the issues we’ve touched on today and some new ones. I am going to introduce them now. To my immediate left is Jo Laird who is now of counsel at Patterson Belknap. Jo has a varied practice in all kinds of art law matters, representing collectors, museums, galleries and dealers. She was, prior to joining Patterson Belknap, the General Counsel of Christie’s, Inc., which is how I first met her because in my previous job at the U.S. Attorney’s office we had a lot of dealings with one another. So, I know Jo to be an expert on many matters of art law. She is also a Columbia Law School graduate-so we are really happy to have her here. To her left is Michael Salzman who is the co-head of the art law practice at Hughes Hubbard & Reed and also known to many of you in the room as an art lawyer with a lot of experience in a lot of different cases. Last is Donn Zaretsky, who is actually an alumni of Paul, Weiss-another thing we have in common-but now with John Silberman Associates where he has an art law and entertainment practice. Donn represents a lot of artists and I am hoping that that is one perspective we can bring out today. In addition, Donn is the author of the Art Law Blog, which-if you are not familiar with it-you should check out. It is a really wonderful blog and resource and worth reading
- …
