50 research outputs found
Assessment of Economic Growth of the Republic of Moldova in the Context of Global Economic Crisis
No full textThe world economic crisis has had a negative impact on the economic development of Moldova, but recent trends show that in 2010 we were able to forecast a small economic growth. The author examines the problems faced by the Moldavian economy which shackle its strong recovery. The current evolutions of the Moldavian economy are analyzed in the paper as well.remittances, foreign trade, competitiveness, structural reforms, macroeconomic environment
Hypospadias in Istanbul: Incidence and risk factors
No full textBackground: The aim of the present prospective study was to determine the incidence of hypospadias in newborns in one of the busiest teaching hospitals of Istanbul, and to investigate the risk factors
The effect of maternal anemia on anthropometric measurements of newborns
No full textObjectives: To evaluate the relation between maternal prenatal hemoglobin concentration and neonatal anthropometric measurements
LABİOPLASTİ KONULU MAKALELERİN BİLİM HARİTALAMA TEKNİĞİ İLE ANALİZİ
No full textObjective: Labiaplasty is the surgical reduction of the labia minora. Labiaplasty has become increasingly popular in recent years. The aim of this study is to analyze the studies on labiaplasty in the literature with the science mapping technique.
Materials and Methods: The data used in this study were obtained from the Web of Science Core Collection, Scopus and PubMed databases, which contain abstracts and references from high quality and effective scientific articles. The dataset is assembled using the Python programming language and the underlying Pandas library. The obtained data were analyzed with Biblioshiny in R-Studio.
Results: The results of the analysis made on the basis of the countries of the responsible authors of the studies on labiaplasty show that the USA is ahead with a total of 85 articles according to the number of articles. Gemma Sharp is the author with the highest number of articles with 19 articles in terms of total number of articles. The source that publishes the most articles on labiaplasty is the Aesthetic Surgery Journal with 58 articles.
Conclusion: In our article, the subject of labiaplasty has been analyzed in terms of science mapping, which is the most interesting subject of the last period. It is considered that this study, which is frequently encountered in the literature, will shed light on the studies in its field
Design, Synthesis, and Molecular Modeling Studies of Novel Coumarin Carboxamide Derivatives as eEF-2K Inhibitors
No full textEukaryotic
elongation factor-2 kinase (eEF-2K) is an unusual alpha
kinase commonly upregulated in various human cancers, including breast,
pancreatic, lung, and brain tumors. We have demonstrated that eEF-2K
is relevant to poor prognosis and shorter patient survival in breast
and lung cancers and validated it as a molecular target using genetic
methods in related in vivo tumor models. Although
several eEF-2K inhibitors have been published, none of them have shown
to be potent and specific enough for translation into clinical trials.
Therefore, development of highly effective novel inhibitors targeting
eEF-2K is needed for clinical applications. However, currently, the
crystal structure of eEF-2K is not known, limiting the efforts for
designing novel inhibitor compounds. Therefore, using homology modeling
of eEF-2K, we designed and synthesized novel coumarin-3-carboxamides
including compounds A1, A2, and B1–B4 and evaluated their activity by performing in silico analysis and in vitro biological assays in breast
cancer cells. The Molecular Mechanics/Generalized Born Surface Area
(MM/GBSA) area results showed that A1 and A2 have interaction energies with eEF-2K better than those of B1–B4 compounds. Our in vitro results indicated that compounds A1 and A2 were highly effective in inhibiting eEF-2K at 1.0 and 2.5 μM
concentrations compared to compounds B1–B4, supporting
the in silico findings. In conclusion, the results
of this study suggest that our homology modeling along with in silico analysis may be effectively used to design inhibitors
for eEF-2K. Our newly synthesized compounds A1 and A2 may be used as novel eEF-2K inhibitors with potential therapeutic
applications
Abstract 4787: New and potent small molecule as EF2K inhibitor: A novel EF2K inhibitor
No full textAnnual Meeting of the American-Association-for-Cancer-Research (AACR) -- MAR 29-APR 03, 2019 -- Atlanta, GA[Anstract Not Available]Amer Assoc Canc Re
Increasing Low Birth Weight Rates: Deliveries in a Tertiary Hospital in Istanbul
No full textObjective: Prevalence of low birth weight deliveries may vary across
different environments. The necessity of determination of regional data
prompted this study. Methods: Information of all deliveries from
January 2004 to December 2008 was obtained from delivery registry
records retrospectively. Initial data including birth weight, vital
status, sex, maternal age and mode of delivery were recorded using
medical files. The frequency of low birth weight, very low birth
weight, extremely low birth weight and stillbirth deliveries were
determined. Findings: Among 19,533 total births, there were 450
(23.04 per 1000) stillbirths. Low birth weight rate was 10.61%. A
significant increase in yearly distribution of low birth weight
deliveries was observed (P<0.001). Very low birth weight and
extremely low birth weight delivery rates were 3.14% and 1.58%
respectively. Among 2073 low birth weight infants, 333 (16.06%) were
stillbirths. The stillbirth delivery rate and the birth of a female
infant among low birth weight deliveries were significantly higher than
infants with birth weight =2500g (P<0.001, OR=28.37), (P<0.001)
retrospectively. There was no statistical difference between low birth
weight and maternal age. The rate of cesarean section among low birth
weight infants was 49.4%. Conclusion: High low birth weight and
stillbirth rates, as well as the increase in low birth weight
deliveries over the past five years in this study are striking. For
reduction of increased low birth weight rates, appropriate intervention
methods should be initiated
PP-168. Evaluation of two different types of parenteral nutrition on early growth of preterm infants
No full text
