1,012 research outputs found
In Memory of Sir Peter J. Lachmann, 1931–2020 : Bees, Tickover, Factor I and Complement
No full textWe were all very sorry to hear that our highly esteemed colleague and one of the true pioneers of complement research, Professor, Sir Peter J [...
Virukset ja me - onnistuuko sopeutuminen?
No full textViruksia ei pidetä elävinä organismeina. Ne kykenevät kuitenkin häiritsemään elämää merkittävästi. SARS-CoV-2 koronaviruksen toimintaa ohjaa yksi ainoa RNA-molekyyli, jossa on noin 30 000 emäsparia. RNA-virusten mittakaavassa tämä on suuri genomi. Se koodaa 29:ää eri proteiinia. Tällä arsenaalilla on saatu ihmiskunta polvilleen
CRP ja komplementti kudosvaurioiden tunnistuksessa ja tulehduksen säätelyssä
No full textPeer reviewe
SALSA : A Regulator of the early Steps of Complement Activation on Mucosal Surfaces
No full textComplement is present mainly in blood. However, following mechanical damage or inflammation, serous exudates enter the mucosal surfaces. Here, the complement proteins interact with other endogenous molecules to keep microbes from entering the parenteral tissues. One of the mucosal proteins known to interact with the early complement components of both the classical and the lectin pathway is the salivary scavenger and agglutinin (SALSA). SALSA is also known as deleted in malignant brain tumors 1 and gp340. It is found both attached to the epithelium and secreted into the surrounding fluids of most mucosal surfaces. SALSA has been shown to bind directly to C1q, mannose-binding lectin, and the ficolins. Through these interactions SALSA regulates activation of the complement system. In addition, SALSA interacts with surfactant proteins A and D, secretory IgA, and lactoferrin. Ulcerative colitis and Crohn's disease are examples of diseases, where complement activation in mucosal tissues may occur. This review describes the latest advances in our understanding of how the early complement components interact with the SALSA molecule. Furthermore, we discuss how these interactions may affect disease propagation on mucosal surfaces in immunological and inflammatory diseases.Peer reviewe
Disturbances in complement recognition and control in human disease - An editorial to a special issue on "Complement Regulation"
No full textNon peer reviewe
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