196,275 research outputs found
Extended middle east and North Africa: Cervical cancer and human papillomavirus: Can we make the case for prevention in this Relatively Low Prevalence Region?
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Burden of human papillomavirus-related cervical disease in the extended Middle East and North Africa - A comprehensive literature review
OBJECTIVE: This study aimed to analyze the burden of human papillomavirus (HPV) in the Extended Middle East and North Africa (EMENA) region and to discuss the potential impact on HPV-related diseases derived from changing sexual behaviors and perceptions. MATERIALS AND METHODS: A comprehensive retrospective review of the available epidemiological data (publications in the past 30 years until January 2011) on HPV and its related diseases (especially as they relate to the cervix) in the EMENA region was carried out. RESULTS: Analysis of the burden of HPV in the EMENA region highlights an unexpectedly high prevalence of HPV, with rates of HPV ranging from 0percent to 25percent in low-risk women with normal cytology and up to 98percent in those with genital warts and preinvasive and invasive lesions. In addition, cervical cancer screening practices are, at best, opportunistic in most countries of the region; therefore, the observed change in social and sexual behavior in the EMENA population, particularly in youths, could lead to an increase in HPV and its related diseases especially cervical cancer. CONCLUSIONS: This article emphasizes the need for the introduction and standardization of screening practices in the region. Moreover, surveillance studies are needed to enable the identification of HPV type distribution and to determine the potential impact of the introduction of HPV vaccines. 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Supplemental Material - A Test of Minority Stress Theory with Asian Americans
Supplemental Material for A Test of Minority Stress Theory with Asian Americans by Nina Lei, Brandon L. Velez, Judy M. Seoud, and Wei N. Motulsky in The Counseling Psychologist</p
Cervical adenocarcinoma: Moving towards better prevention
Objective: Although cervical screening has led to a significant decline of invasive cervical cancer (ICC) in developed countries, it remains the third leading cause of cancer in women worldwide. While the majority of the decline in ICC can be attributed to a reduction in squamous cell carcinoma (SCC), the incidence of cervical adenocarcinoma (ADC), absolute and relative to SCC, has been rising steadily, especially in younger women. This paper examines oncogenic human papillomavirus (HPV) infections, the risk of developing cervical ADC and its prognosis. It analyzes differences between ADC and SCC and considers current and future methods for prevention. Methods: PubMed, publicly available websites and congress abstracts were searched for data and literature. Results: HPV-16, -18 and -45 account for approximately 90percent of ADC worldwide. Typically, α-7 genotypes, which include HPV-18 and -45, are more commonly associated with ADC than SCC. The difficulty in detecting ADC through screening as well as changing sexual habits and increased HPV transmission may account for its increase; an increase in SCC may not be observed because of improved detection of pre-malignant SCC compared with pre-malignant ADC. HPV testing shows promise for screening women ≥30. years of age, but α-7 genotypes may be underrepresented in precancerous lesions. Clinical trial data indicate that current vaccines have high efficacy against HPV-16-18-related cervical intraepithelial neoplasia. Moreover, these vaccines also demonstrate a different level of protection beyond the HPV vaccine types, therefore increasing the overall vaccine efficacy. Such broad coverage could translate into a considerable reduction in the incidence of ADC. 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Detailed gene and allele content analysis of three homozygous KIR haplotypes
The killer immunoglobulin-like receptors are a highly polymorphic family of receptors encoded by 15 genes clustered on 19q13.4. Because of the complexity of the genetic analysis of the KIR cluster, much of the data regarding KIR sequences and alleles has been generated by cDNA typing and partial sequencing. Here we report the genomic sequencing of the KIR genes in individuals with three different haplotypes homozygous by descent. We provide a detailed analysis of their haplotypes and identify new alleles for KIR3DL3 and KIR2DL1. The primers we describe will be a valuable tool for studying the involvement of the KIR genes in various human diseases. © 2006 R. Slim.Carrington M, 2003, KIR GENE CLUSTER; Carrington M, 2005, J EXP MED, V201, P1069, DOI 10.1081-jem.20042158; Gedil MA, 2005, TISSUE ANTIGENS, V65, P402, DOI 10.1111-j.1399-0039.2005.00380.x; Hiby SE, 2004, J EXP MED, V200, P957, DOI 10.1084-jem.20041214; Hsu KC, 2002, IMMUNOL REV, V190, P40, DOI 10.1034-j.1600-065X.2002.19004.x; Khakoo SI, 2004, SCIENCE, V305, P872, DOI 10.1126-science.1097670; Kinoshita T, 2005, J BIOL CHEM, V280, P21720, DOI 10.1074-jbc.M410057200; Lanier LL, 1998, ANNU REV IMMUNOL, V16, P359, DOI 10.1146-annurev.immunol.16.1.359; Luszczek W, 2004, HUM IMMUNOL, V65, P758, DOI 10.1016-j.humimm.2004.05.008; Martin AM, 2004, GENE, V335, P121, DOI 10.1016-j.gene.2004.03.018; Martin MP, 2002, NAT GENET, V31, P429, DOI 10.1038-ng934; Martin MP, 2003, J IMMUNOL, V171, P2192; Moretta L, 2004, CURR OPIN IMMUNOL, V16, P626, DOI 10.1016-j.coi.2004.07.010; Murdoch S, 2006, NAT GENET, V38, P300, DOI 10.1038-ng1740; Rajalingam R, 2004, J IMMUNOL, V172, P356; SEOUD M, 1995, OBSTET GYNECOL, V86, P692, DOI 10.1016-0029-7844(95)00033-N; Trundley AE, 2006, IMMUNOGENETICS, V57, P904, DOI 10.1007-s00251-005-0060-7; Uhrberg M, 1997, IMMUNITY, V7, P753, DOI 10.1016-S1074-7613(00)80394-5; Uhrberg M, 2005, EUR J IMMUNOL, V35, P10, DOI 10.1002-eji.200425743; Varla-Leftherioti M, 2003, AM J REPROD IMMUNOL, V49, P183, DOI 10.1034-j.1600-0897.2003.00018.x; Yen JH, 2001, J EXP MED, V193, P1159, DOI 10.1084-jem.193.10.115910111
Inguinal ovary after controlled ovarian hyperstimulation-infrequent, infrequently recognized, or observer variation?
[No abstract available]BAZI T, 2006, FERTIL STERIL, V85, pE5; Hinckley MD, 2003, FERTIL STERIL, V80, P445, DOI 10.1016-S0015-0282(03)00668-X; Idil M, 2006, FERTIL STERIL, V85, DOI 10.1016-j.fertnstert.2005.11.066; Mayer V, 1941, ARCH SURG-CHICAGO, V43, P397; Ombelet W, 2003, HUM REPROD, V18, P858, DOI 10.1093-humrep-deg1911
Burden of human papillomavirus infections and related diseases in the extended middle east and North Africa Region
In this chapter, we present the available information on the burden of human papillomavirus (HPV)-related cancers (cancers of the cervix, anogenital cancers, and cancers of the oral cavity and pharynx), as well as available data on the prevalence and distribution of HPV types in women with and without cervical cancer, for the countries of the Extended Middle East and North Africa region (EMENA). The EMENA region is characterized by societies that share similar cultures and religions and that are considered to have a more conservative sexual behaviour compared to Western societies. The incidence of cervical cancer is estimated to be relatively low, although it is difficult to assess precisely because systematic and national cancer registries are lacking in many countries of the EMENA region. In these countries, nationwide programs of cervical cancer screening do not exist or are based on a limited opportunistic cytology-based screening, which often lacks quality assurance. The incidence of anogenital cancers other than cervix is very low. The incidence of cancers of the oral cavity and pharynx is relatively high in some countries, particularly in Pakistan. Relatively low levels of HPV prevalence have been observed in the several surveys conducted in the EMENA region, although only few young women were included in these studies. Possible changes in lifestyle and sexual behaviour in younger generations might, however, change this scenario. Thus, improving the information on the burden of HPV-related cancers and on the HPV prevalence in the general population is essential to develop a comprehensive intervention policy for future management of cervical cancer in this area.This article forms part of a regional report entitled . Comprehensive Control of HPV Infections and Related Diseases in the Extended Middle East and North Africa Region Vaccine Volume 31, Supplement 6, 2013. Updates of the progress in the field are presented in a separate monograph entitled . 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Dr. Duane M. Jackson, Morehouse College, July 2011
This video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
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