85 research outputs found
Analisis Pemasaran Sosial dengan Metode SWOT pada Program Keluarga Berencana (KB) di Kantor Badan TASKIN PMPKB Kabupaten Tanah Datar: Indonesia
No full textABSTRACT
The purpose of this study is to analyze internal and external factors that influence the social marketing strategy of the Family Planning (KB) program at the Tanah Datar District TASKIN PMPKB Office and analyze what strategies are appropriate to be applied to the Tanah Datar TASKIN PMPKB Agency Office. In this study, the author uses the SWOT method to analyze internal and external factors and what strategies are appropriate to be applied to the TASKIN PMPKB Office of Tanah Datar Regency. Based on the SWOT analysis, the total score of the strength factor is more dominant or greater than the weakness factor at the Tanah Datar TASKIN PMPKB Office, which is 1.58 compared to 1.49.
While the external factor, the opportunity score is greater than the threat score at the Tanah Datar TASKIN PMPKB Office, which is 1.81 compared to 1.14, so it can be concluded that all existing weaknesses can be covered or overcome with strengths. exist, as well as threats that come from outside can be overcome with the opportunities that exist for the Tanah Datar District TASKIN PMPKB Office
Biological activities of the Ornithogalum orthophyllum and its in silico ADMET profile
No full textBackground: The bulbs and aerial parts of Ornithogalum are used in Turkey both as food and to treat various ailments, and some of its medical applications are well known. However, the biological activities of Ornithogalum orthophyllum have not yet been investigated. The objective of this study was to examine the antioxidant, urease and cholinesterase enzyme inhibition, and cytotoxic activities of different extracts obtained from the bulb and aerial parts of the O. orthophyllum plant. In addition, the absorption, distribution, metabolism, excretion, and toxicity properties of some phenolic compounds in plants were examined in silico. Methods: The antioxidant activity of the extracts obtained from the aerial parts of O. orthophyllum was investigated using the 2,2-diphenyl-1-picrylhydrazyl, 2,2-azinobis- (3-ethylbenzothiazoline-6-sulphonic acid), ferric reducing antioxidant power, and cupric reducing antioxidant capacity methods. Urease and cholinesterase enzyme inhibition were determined by using the indophenol and Gilman methods, respectively. The cytotoxic activity of the extracts was measured using a test based on the luminometric readings of the adenosine triphosphate levels of the cells. pkCSM, a free online web server (http://structure.bioc.cam.ac.uk/pkcsm) was used to predict the properties of the compounds analyzed. Results: The methanol extract of the aerial parts of O. orthophyllum was observed to have strong antioxidant and acetylcholinesterase enzyme inhibition potential. The petroleum ether extract of the aerial parts showed the highest anti-urease activity. The chloroform extract of the aerial parts exhibited the highest cytotoxic effect against A431 human epidermoid carcinoma cells. The absorption percentages of protocatechuic acid, p-hydroxybenzoic acid, vanillic acid, and p-coumaric acid compounds from the small intestine were between 71.17% and 93.49%, which were quite high. All the compounds were predicted to be unable to penetrate the central nervous system due to their inability to cross the blood-brain barrier. Not all compounds analyzed were predicted to have mutagenic, hepatotoxic, or minnow toxicity effects. Conclusion: The extracts obtained from the aerial parts of O. orthophyllum have strong biological activity and contain compounds that arc well-absorbed and do not have mutagenic, hepatotoxic, or minnow toxicity effects, suggesting that they can be used as natural medicinal and nutritional sources in the future
Scientific people named in the classification of vasculitis
No full textAbstract The first International Chapel Hill Consensus Conference was held in 1994. There have been suggestions about the nomenclature of systemic vasculitis. Important categories were added to the classification of vasculitis, and many changes were made for disease names in the second Chapel Hill Consensus Conference 2012, which were not included in the Chapel Hill Consensus Conference 1994. The new nomenclature was introduced instead of being referred to by many names such as Churg-Strauss and Wegener"s. New categories such as Behçet"s and Cogan etc. were also added. These people are honored by the classification. They contribute to science through their case studies, scientific articles, and observations. This article reviews only eponyms present in the current classification of vasculitis. The aim of this paper is to give information about scientists mentioned in the classification of vasculitis
Scientific people named in the classification of vasculitis
No full textAbstractThe first International Chapel Hill Consensus Conference was held in 1994. There have been suggestions about the nomenclature of systemic vasculitis. Important categories were added to the classification of vasculitis, and many changes were made for disease names in the second Chapel Hill Consensus Conference 2012, which were not included in the Chapel Hill Consensus Conference 1994. The new nomenclature was introduced instead of being referred to by many names such as Churg-Strauss and Wegener”s. New categories such as Behçet”s and Cogan etc. were also added. These people are honored by the classification. They contribute to science through their case studies, scientific articles, and observations. This article reviews only eponyms present in the current classification of vasculitis. The aim of this paper is to give information about scientists mentioned in the classification of vasculitis
Nomes de cientistas usados na classificação das vasculites
No full textResumoA primeira International Chapel Hill Consensus Conference (CHHC) ocorreu em 1994. Fizeram‐se sugestões sobre a nomenclatura das vasculites sistêmicas. Na segunda CHHC, 2012, adicionaram‐se importantes categorias à classificação da vasculite e fizeram‐se várias mudanças em nomes de doenças que não estavam incluídas na CHCC 1994. Introduziu‐se uma nova nomenclatura em vez de se usarem nomes como Churg‐Strauss e Wegener. Também foram adicionadas novas categorias, como de Behçet e Cogan etc. Essas pessoas são homenageadas pela classificação. Elas contribuíram para a ciência com seus estudos de caso, artigos científicos e observações. Este artigo analisa apenas epônimos presentes na classificação atual das vasculites. O objetivo é prestar informações sobre os cientistas mencionados na classificação das vasculites.AbstractThe first International Chapel Hill Consensus Conference (CHHC) was held in 1994. There have been suggestions about the nomenclature of systemic vasculitis. Important categories were added to the classification of vasculitis, and many changes were made for disease names in the second CHHC 2012, which were not included in the CHCC 1994. The new nomenclature was introduced instead of being referred to by many names such as Churg‐Strauss and Wegener”s. New categories such as Behçet”s and Cogan etc. were also added. These people are honored by the classification. They contribute to science through their case studies, scientific articles, and observations. This article reviews only eponyms present in the current classification of vasculitis. The aim of this paper is to give information about scientists mentioned in the classification of vasculitis
Editorial board member and prolific author status positively shorten publication time
No full textPublication speed is one of the important aspects of scholarly communication today since a good deal of research performance evaluation systems are based on published articles. This study aims to reveal the factors affecting the publication speed of journals. In this context, six library and information science (LIS) journals, ASLIB Journal of Information Management, Journal of Documentation, Journal of Informetrics, Journal of the Association for Information Science and Technology, Online Information Review, and Scientometrics are analysed in terms of their publication speed. Results show that being an editorial board member or prolific author for journals significantly shortens the duration of publication. Moreover, when there is at least one editorial board member or prolific author in the author group, the duration of the publication is shorter than the articles from the unknown authors. However, the fact that no significant difference is determined between single- and double-blind peer review and the duration of publication process gives an idea about the scientific levels of articles written by editorial board members or prolific authors. In this regard, our approach is to examine other factors affecting the publication speed by conducting multi-dimensional analysis in future studies
Full-Waveform Inversion for Breast Ultrasound
No full textBreast cancer is the most common type of cancer for women and in developed countries it forms one of their largest threats. Many studies have shown that early detection by screening is important for achieving a successful treatment and reducing the mortality rate. Nowadaysmammography is the gold standard for breast cancer screening. However, mammography has several drawbacks including the use of ionizing radiation, a painful procedure, and poor performance with dense breasts. Magnetic resonance imaging (MRI) could form an alternative as it has some powerful features. However, the high examination and equipment costs as well as the use of contrast agents limits its applicability. Another potential alternative for breast cancer screening is ultrasound. Ultrasound has the advantage over mammography orMRI that it is safe, cheap and patient-friendly. With ultrasound, a tumor can be detected since healthy breast tissues and cancerous tissues have different acoustic properties. All these features make ultrasound a promising candidate as a screening modality for breast cancer. Hand-held ultrasound scans are frequently used for breast imaging in hospitals. With these scanners reflectivity images are generated. These images typically show the boundaries between different tissues. Even when these exams are conducted by trained radiologists operator-dependency occurs. To eliminate this, automated full-breast ultrasound scanners have been developed where the transducer slides over the breast. However, as the imaging principle remains the same, only reflectivity images are generated. To avoid significant breast deformation as well as to scan the breast from as many sides as possible water-bath scanning systems have been developed. These systems have the additional advantage that both reflection and transmission measurements are obtained. This mixture of different measurement types make it feasible to obtain better images by employing advanced processing techniques. One promising imaging method is full-waveform inversion (FWI). FWI aims to match a modeled wavefield to a measured wavefield by adjusting the acoustic medium parameters. A minimization problem is constructed and solved to this aim. As a result, images showing quantitative information about the different tissues are obtained. This quantitative information aids to the characterization and identification of the different tissues. However, there are some challenges when applying FWI. One of the biggest challenges is its computational complexity. By the inclusion of wave phenomena such as diffraction, refraction, scattering and dispersion - needed to explain the measured data in great detail - the computational complexity of FWI has become significantly larger than conventional - mainly ray based - imaging methods. In this work, we investigate the applicability of contrast source inversion (CSI) as an FWI method for breast ultrasound. To this end, we first introduce our full-waveform forward modeling method which is based on solving an integral equation. With a synthetic example,we investigate howeach mediumparameter (compressibility, density, and attenuation) affects the scattered pressure field. The obtained results show that attenuation, in contrast to compressibility and density, has only little effect on the wavefield for frequencies below 1MHz. From that we conclude, that for these frequencies only attenuation can be neglected in our inversion. We also compare the results from our full-waveform modeling method with results obtained after commonly made approximations such as Born, ray-based and paraxial approximations. We observe from the presented numerical results that with each approximation important phenomena normally present in the full-wave data are absent. For this reason, we recommend to use a full-wave modeling method to compute synthetic measurement data.ImPhys/Medical Imagin
The relationship between platelet distribution width and disease activity in patients with polymyositis
No full textINTRODUCTION: Muscle enzymes are an indicator of ongoing muscle damage and disease activity in patients with idiopathic inflammatory myopathy. Although platelet-related parameters have been shown to be useful as markers of disease activity in autoimmune diseases, the relationship between platelet distribution width (PDW) and disease activity has not been previously studied in polymyositis. We aimed to determine the relationship between PDW and disease activity in patients with polymyositis. MATERIAL AND METHODS: Twenty-seven patients with polymyositis and thirty healthy controls were included in the study. Disease activity was evaluated using the myositis disease activity assessment Visual Analogue Scale (MYOACT) and the Myositis Intention to Treat Index (MITAX). The relationship between PDW and disease activity was evaluated using Pearson’s or Spearman’s correlation and reliability was assessed using correlation coefficients. RESULTS: The mean platelet volume (MPV) and plateletcrit (PCT) were significantly higher and PDW was significantly lower in patients with polymyositis compared to the control group. The mean PDW levels were lower in patients with constitutional symptoms and arthralgia/arthritis (p < 0.005). Although PDW levels were lower in patients with mechanical hand, lung involvement, or dysphagia compared to patients without, there was no statistically significant difference between them. Platelet distribution width was found to be negatively correlated with disease activity. CONCLUSIONS: We found that PDW was negatively correlated with MYOACT and MITAX, widely used tools in assessing the disease activity of polymyositis. Based on this, PDW may be utilized as a non-invasive potential index to assess disease activity in patients with polymyositis
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