79 research outputs found

    Synthesis, Anti-Inflammatory, and Analgesic Activities of Derivatives of 4-Hydroxy-2-benzoxazolone

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    Benzoxazolones are widely distributed in plants and are of increasing interest for a variety of pharmacological properties, such as detoxification, antibacterial, anti-inflammatory, and analgesic activities and tranquilizers (Michaelidou and Hadjipavlou-Litina, 2005; Doğruer et al., 1998). 4-Hydroxy-2-benzoxazolone (HBOA) is one of the major bioactive compounds in traditional Chinese herb drug Acanthus ilicifolius  (Peng and Long, 2006) which has obvious anti-inflammatory and analgesic activities (Huo et al., 2004; Mani Senthil Kumar et al., 2008; Babu et al., 2001). In this research, we used 2-nitroresorcinol as starting material to prepare HBOA with a novel “one-pot-way.” Derivatives of HBOA TC-2∼TC-4 were obtained via electrophilic reagents and reacted with corresponding primary amines to afford Schiff Base derivatives TC-5∼TC-10 for further study. Anti-inflammatory and analgesic activities of those derivatives were determined by using carrageenan-induced rat paw edema test. The analgesic activities of the derivatives were determined by the hot-plate test

    Solving Differential Equation via Orthogonal Branciari Metric Spaces

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    In this paper, we investigate an orthogonal L⋆-contraction map concept and prove the fixed-point theorem in an orthogonal complete Branciari metric space (OCBMS). We also provide illustrative examples to support our theorems. We demonstrated the existence of a uniqueness solution to the fourth-order differential equation using a more orthogonal L⋆ contraction operator in OCBMS as an application of the main results

    IIPQ controlled three phase three level four wire T-type vienna rectifier for high efficient off board fast EV charging station with enhanced system stability

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    Nowadays, the integration of fast Electric Vehicle (EV) charging station with microgrid becomes very challenges due to non-linear behavior of load unit. These charging unit produce harmonic distortions which reduce the power quality. To ensuring the stable voltage and current profile as per IEEE standard while connecting Grid-to-Vehicle (G2V) has becomes challenging issue. In this paper, an efficient off board 3P3L4W (Three-Phase Three-Level Four-Wire) T-Type Vienna Rectifier (TTVR) for fast EV charging stations with suppressed Total Harmonic Distortion (THD) level and power quality enhancement is presented. TTVR interfaced with Improved Instantaneous real and reactive power (IIPQ) control strategy to maintain low switching losses, enhanced steady state and dynamic load response. Hence, this proposed Fuzzy Logic Controller based IIPQ control strategy has been employed to maintain constant DC-Link voltage and capacitor voltage VC1, VC2. This method is validated by using MATLAB and experimental validation also carried with 15KW laboratory prototype using digital signal peripheral Interface controller (dsPIC30F4011), Rapid Hyper-fast Recovery Glass (RHRG30120) power diodes and Silicon Carbide Metal-Oxide-Semiconductor Field-Effect Transistors (SiC MOSFETs IRFP260) switches to maintain high switching stress and low ON-State losses. The average THD value obtained is close to 2.5% which implies power quality enhancement, battery charging efficiency and highlighting the feasibility and adaptability of the proposed system for energy conversion and advanced EV charging station infrastructure development

    Isolation of Flavonol of Tephrosia purpurea

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    ABSTRACT Flavonoids have been reported as naturally occurring compounds and considered as secondary metabolites responsible for biological activities. The flavonoids are divided into several classes, i.e., anthocyanins, flavonols, flavones, flavanones, dihydro flavonols, chalcones etc. A flavonol, Kaempferol 7-O-(rhamnosyl)-glucoside, was isolated from whole plant of Tephrosia purpurea. The isolated compound was identified by melting point, chemical test, IR, NMR and mass spectra
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