170,132 research outputs found
Un’esperienza europea: lo studio delle discipline classiche e il loro insegnamento nella scuola austriaca
No full textIndagine su metodi, strumenti e contenuti della formazione degli insegnanti di latino e greco in Austri
Medea: la complessità di un mito e la sua persistenza nella cultura contemporanea
No full textpresentazione ed elaborazione di un modulo didattico interdisciplinare (greco-latino) sul tema di Medea, in particolare della Medea di Euripide e di Seneca, e della sua fortuna nella cultura moderna europe
La formazione dell'insegnante di latino e greco nei Gymnasien del Baden-Wuerttemberg (Germania)
No full textProsecuzione della ricerca nell'ambito della formazione degli insegnanti di latino e greco in area tedesca, con particolare riferimento al Land del Baden- Wuerttemberg, dove il percorso formativo dell'insegnante ha assunto negli anni carattere di centralità sia per i notevoli investimenti sia per il rilevante interesse presso le Istituzion
Program transformation for development, verification, and synthesis of programs
No full textThis paper briefly describes the use of the program transformation methodology for the development of correct and efficient programs. In particular, we will refer to the case of constraint logic programs and, through some examples, we will show how by program transformation, one can improve, synthesize, and verify programs
Constant mean curvature graphs on exterior domains of the hyperbolic plane
No full textWe prove an existence result for non rotational constant mean curvature ends in H2 ×R, where H2 is the hyperbolic real plane. The value of the curvature is h ∈ (0, 12). We use Schauder theory and a continuity method for solution of the prescribed mean curvature equation of exterior domains of H2. We also prove a fine property of the asymptotic behavior of the rotational ends introduced by Sa Earp and Toubiana
Formazione in agricoltura sociale, tra multifunzionalità dell’azienda agricola e welfare di comunità.
No full text
Protein kinase C theta co-operates with calcineurin in the activation of slow muscle genes in cultured myogenic cells
No full textAdult skeletal muscle fibers can be divided into fast and Slow twitch subtypes on the basis of specific contractile and metabolic properties, and on distinctive patterns of muscle gene expression. The calcium, calmodulin-dependent protein phosphatase, calcineurin, stimulates slow fiber-specific genes (myoglobin (Mb), troponin I Slow) in Cultured skeletal muscle cells, as well as in transgenic mice, through the co-operation of peroxisome-proliferation-activator receptor gamma co-activator 1 alpha (PGC1 alpha) myocyte enhancer factor 2 (MEF2), and nuclear factor of activated T cells (NFAT) transcription factors. Specific protein kinase C isoforms have been shown to functionally co-operate with calcineurin in different cellular models. We investigated whether specific protein kinase C isoforms are involved in calcineurin-induced slow skeletal muscle gene expression. By pharmacological inhibition or exogenous expression Of mutant forms, we show that protein kinase C theta (the protein kinase C isoform predominantly expressed in skeletal muscle) is required and co-operates with calcineurin in the activation of the Mb promoter, as well as in the induction of slow isoforms of myosin and troponin I expression, in cultured muscle cells. This co-operation acts primarily regulating MEF2 activity, as shown by using reporter gene expression driven by the Mb promoter Mutated in the specific binding sites. MEF2 activity on the Mb promoter is known to be dependent on both PGC1 alpha and inactivation of histone deacetylases (HDACs) activity. We show in this study that protein kinase C theta is required for, even though it does not co-operate in, PGC1 alpha-dependent Mb activation. Importantly, protein kinase C theta regulates the HDAC5 nucleus/cytoplasm location. We conclude that protein kinase C theta ensures maximal activation of MEF2, by regulating both MEF2 transcriptional complex formation and HDACs nuclear export
One-step synthesized CuO-CeO2-Al2O3 system as catalyst for OSRM process
No full textA structurally organized mesoporous CuO/CeO2/Al2O3 catalyst was prepared by a new single step sol-gel synthesis, characterized by TGA,XRD, N2 physisorption and TPR and tested for oxidative steam reforming of methanol (OSRM)at T=200-4000°C , H2O/CH3OH/O2 ratios = 1.1/1/0.12 CH3OH concentration 17.8% GHSV= 6x10EXP4 h-1. The catalyst contained Cu2+ species strongly interacting with CeO2, besides a CuO phase highly dispersed in alumina. After reduction in H2 the catalyst compared with more conventional CuO/CeO2 systems, showed good activity and H2 yield in OSRM process
Altered distribution of protein kinase C in dystrophic muscle cells and its modulation by liposome-delivered phospholipids
No full textThe activity and subcellular distribution of the calcium-phospholipid dependent protein kinase (protein kinase C) were studied in normal and dystrophic muscle cells Image . Clonal strains of satellite cells, isolated from normal and dystrophic (C57BL/6J/dydy) mice, differentiate Image at a comparable level (over 80% of fusion). Differentiated myotubes were homogenized and separated into a soluble and a particulate fraction. The activity of protein kinase C was assayed in both fractions, and was found to be mainly in the cytosol of normal cells, whereas it was mainly associated to the membrane fraction of dystrophic cells. This altered distribution of the enzyme was likely consequent to alterations in the phospholipid composition of the dystrophic cell membrane, since it was possible to partially revert the situation by modifying the membranes with liposome-delivered phospholipids. Splenic lymphocytes from dystrophic mice showed an altered distribution of protein kinase C similar to that observed in muscle cells. The possible biochemical basis and the functional consequences of this altered distribution of the enzyme in the dystrophic cells are discussed
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