4 research outputs found
Political consequences of intra-village inequalities in rural transformation - a study of two villages in West Bengal
No full textClosure of Schools and Migration of Adolescent Tribal Girls: A Case Study of Surat
No full textThis paper is an empirical study of the consequences of the prolonged closure of schools and other educational institutions for adolescent tribal girls, migrating to the construction sector of Surat in search of work. It attempts to argue that, unlike financial hardship, disruption in education induced by the pandemic brought them to the informal labour market where the entry-level age group is now much younger, exacerbating their existing vulnerabilities
Migrants’ livelihoods during the pandemic: Challenges and opportunities
No full textInformal migrant workers in metropolitan cities of India have faced multiple forms of vulnerabilities in the last two years of the pandemic. Linkages across schemes for such workers are absolutely critical to creating a social security net that protects them from falling into similar cycles of poverty and destitution during macro and micro economic distresses.
This is a report and observation on the socio-economic condition of the migrant labourers against the background of the government’s labour-related policy in the post-pandemic period
Nuclear Factor-KB-Mediated Transforming Growth Factor-beta-Induced Expression of Vimentin Is an Independent Predictor of Biochemical Recurrence after Radical Prostatectomy
No full textPurpose: Transforming growth factor-beta (TGF-beta)-mediated epithelial-to-mesenchymal transition (EMT) has been shown to occur in some cancers; however, the pathway remains controversial and varies with different cancers. In addition, the mechanisms by which TGF-beta and the EMT contribute to prostate cancer recurrence are largely unknown. In this study, we elucidated TGF-beta-mediated EMT as a predictor of disease recurrence after therapy for prostate cancer, which has not been reported before. Experimental Design: We analyzed TGF-beta-induced EMT using nuclear factor-KB (NF-KB) as an intermediate mediator in prostate cancer cell lines. A total of 287 radical prostatectomy specimens were evaluated using immunohistochemistry in a high-throughput tissue microarray analysis. Levels of TGF-beta signaling components and EMT-related factors were analyzed using specific antibodies. Results were expressed as the percentage of cancer cells that stained positive for a given antibody and were correlated with disease recurrence rates at a mean of 7 years following radical prostatectomy. Results: In prostate cancer cell lines, TGF-beta-induced EMT was mediated by NF-KB signaling. Blockade of NF-KB or TGF-beta signaling resulted in abrogation of vimentin expression and inhibition of the invasive capability of these cells. There was high risk of biochemical recurrence associated with tumors that displayed high levels of expression of TGF-beta 1, vimentin, and NF-KB and low level of cytokeratin 18. This was particularly true for vimentin, which is independent of patients' Gleason score. Conclusions: The detection of NF-KB-mediated TGF-beta-induced EMT in primary tumors predicts disease recurrence in prostate cancer patients following radical prostatectomy. The changes in TGF-beta signaling and EMT-related factors provide novel molecular markers that may predict prostate cancer outcomes following treatment.OncologySCI(E)33ARTICLE103557-35671
