1,720,968 research outputs found
A dysprosium-based metal-organic framework: Synthesis, characterization, crystal structure and interaction with calf thymus-DNA and bovine serum albumin
No full textA dysprosium-based metallo-organic framework (MOF) containing calcium ions formulated as
{Dy(pyda)3Ca1.5(H2O)6} · 5.5H2O (1) (H2pyda = pyridine-2,6-dicarboxylic acid) was solvothermally synthesized
in ethanolic medium and characterized by physico-chemical and spectroscopic tools. A detailed structural
analysis of the solid state structure of 1 by single crystal X-ray diffraction study showed a tricapped trigonal
prism geometry for lanthanide in the [Dy(pyda)3]3− fragment. The mode of interaction of 1 with calf thymus-
DNA and with protein bovine serum albumin (BSA) was investigated by using absorption and emission spectroscopic
tools. The apparent association constant of complex 1 with CT-DNA was deduced from an absorption
spectral study (Kb = 4.08 × 104 M−1). Spectral and viscosity measurements indicated a groove-binding mode
of 1 with CT-DNA, and from spectroscopic study the formation of a metal complex-BSA adduct was assumed
to be the result of the interaction of 1 with BSA
Nickel(II) complexes of N2S2 donor set ligand and halide/pseudohalides: Synthesis, crystal structure, DNA and bovine/human serum albumin interaction
No full textA series of neutral hexacoordinated nickel(II) complexes of formula [NiII(L)X2] (where L = 3,4-bis(2-pyridylmethylthio)toluene with tetradentate N2S2 donor set and X = chloride (1), azide (2), cyanate (3) and isothiocyanate anion (4)) have been synthesized and isolated in pure form. The complexes were characterized by physicochemical and spectroscopic methods along with detailed structural characterization of 1,2 and 3 by single crystal X-ray diffraction analyses. The structural study showed that the nickel(II) ion has a distorted octahedral geometry being chelated by the tetradentate N2S2 ligand and bound to cis- located choride or pseudohalide anions. In dimethylformamide solution the complexes showed quasi-reversible NiII/NiIII redox
couples in cyclic voltammograms with E1/2 values of +0.723, +0.749, +0.768 and +0.868 V for 1, 2, 3 and 4, respectively. The study of interaction of the complexes with calf thymus DNA, bovine serum albumin (BSA) and human serum albumin (HSA) using spectroscopic and physicochemical tools clearly indicates that the complexes interact with DNA via groove binding mode
Zinc(II) complexes of carboxamide derivatives: Crystal structures and interaction with calf thymus DNA
Full text linkTwo mononuclear zinc(II) complexes of newly designed carboxamide derivatives, formulated as [Zn(L1)3](ClO4)2 (1) and [Zn(L2)3](ClO4)2 (2) [where L1 = N-(furan-2-ylmethyl)-2-pyridinecarboxamide and L2 = N-(thiophen-2-ylmethyl)-2-pyridine-carboxamide], have been isolated in pure form in the reaction of perchlorate salts of Zn(II) with ligands L1 and L2, respectively. The two complexes were characterized by physicochemical and spectroscopic tools, and by X-ray crystal structures of both ligands and the complex 1. In complex 1, zinc(II) is chelated by three ligands with a distorted octahedral geometry. The DNA-binding properties of zinc complexes 1 and 2 have been investigated by spectroscopic methods and viscosity measurements. The results suggest that both complexes 1 and 2 bind to DNA in an intercalation mode between the uncoordinated furan or thiophene chromophore and the base pairs of DNA
Synthesis, characterization, crystal structure and DNA-binding study of four cadmium(II) pyridine-carboxamide complexes
No full textTreatment of perchlorate or nitrate salt of cadmium(II) with carboxamide derivatives (L) generated four novel mononuclear metal complexes, represented as [Cd(L )4](ClO4)2 (1a and 1b) and [Cd(L)2(ONO2)2] (2a and 2b) in appreciable yields (L = L1 = N-(furan-2-ylmethyl)-2-pyridine carboxamide and L = L2 = N-(thiophen-2-ylmethyl)-2-pyridine carboxamide). The complexes have been characterized by FT-IR, UV-Visible, elemental analysis and single crystal X-ray crystallographic analysis which revealed eight coordinated cadmium ions, but in different coordination environments, depending on the counter anion used. In addition, electronic absorption, fluorescence spectroscopy and viscosity measurements revealed a significant interaction of the four complexes with CT-DNA via intercalative/groove binding mode. The intrinsic binding constant Kb obtained varies from 0.4 × 10 4 to 1.11 × 10 5 M−1. The results suggest that neutral complexes 2a and 2b bind to DNA in an intercalative mode. On the other hand, cationic complexes 1a and 1b bind with DNA via weak electrostatic/covalent interaction
Synthesis, crystal structure, redox behavior and DNA-binding properties of a series of copper(II) complexes with two new carboxamide derivatives
No full textFour mononuclear copper(II) complexes of two new carboxamide derivatives formulated as [Cu(L1)2](ClO4)2 (1a), [Cu(L1)2](NO3)2 (1b), [Cu(L2)2(H2O)2](ClO4)2 (2a), and [Cu(L2)2(H2O)](NO3)2(2b) have been isolated in pure form from the reaction of L1 and L2 [where L1 = N-(furan-2-ylmethyl)-2-pyridinecarboxamide and L2 = N-(thiophen-2-ylmethyl)-2-pyridinecarboxamide] with copper(II) salts of perchlorate and nitrate. All the complexes were characterized by physicochemical and spectroscopic tools along with single-crystal X-ray diffraction studies. The structural analyses
showed that 1 is monomeric of square planar geometry with copper(II) chelated by two L1 ligands. Complex 2 differs in coordination geometry, being octahedral and distorted square pyramidal. Two L2 ligands occupy the equatorial positions of the octahedral 2a and the basal sites of the pyramidal
2b, with water molecules that complete the coordination sphere in each case. Electrochemical studies using cyclic voltammetry showed a reversible redox behavior of the copper(II) in 1 and 2. The electronic spectroscopic behavior and the trend of one electron equivalent redox potential corresponding to a CuII/CuI couple have also been confirmed by density functional theory calculations. The spectroscopic and viscosity measurement study in tris–HCl buffer suggested an intercalative interaction of 1a and 2 with calf thymus DNA likely due to the stacking between the non-coordinated
furan and thiophene chromophore with the base pairs of DNA
Palladium (II) and platinum (II) complexes of deprotonated N, N´-bis (2-pyridinecarboxamide)-1, 2-benzene: synthesis, structural characterization and binding interactions with DNA and BSA
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Nickel(II) complexes with 2-(pyridin-3-ylmethylsulfanyl)phenylamine and halide/pseudohalides: Synthesis, structural characterisation, interaction with CT-DNA and bovine serum albumin, and antibacterial activity
No full textA new series of hexacoordinated octahedral nickel(II) complexes of 2-(pyridin-3-ylmethylsulfanyl)phenylamine
(L) formulated as [Ni(L)4(X)2] (1–4) [where X = Cl- (1); NCO- (2); N3- (3) and NCS- (4)] has been
synthesised and characterised by physicochemical, spectroscopic tools. Details of structural study of
complex 1 using single crystal X-ray crystallography showed that distorted tetragonal environment
around nickel(II) ion has been satisfied by four pyridinic-N donors of four organic moieties (L) and two
chloride ions. All the complexes are redox active and the electrochemical study of the complexes showed
only cathodic NiII/NiI redox couples in the range of -0.61 to -695 V versus Ag/AgCl. Interactions of 1
towards calf thymus-DNA by spectroscopic, viscosity-measurement and electrochemical study and
towards bovine serum albumin (BSA) with the help of absorption and fluorescence spectroscopy were
examined. Antibacterial activity of the complexes (1–4) studied by agar disc diffusion method showed
the comparable inhibition activity of the nickel(II) complexes against some pathogenic bacteria namely
Escherichia coli, Vibrio cholerae, Streptococcus pneumonia, Shigella sp. and Bacillus cereus
A bio-attuned ratiometric hydrogen sulfate ion selective receptor in aqueous solvent: structural proof of the H-bonded adduct
No full textA new cell permeable quinazoline based receptor (1) selectively senses HSO4 ions of nanomolar region in 0.1 M HEPES buffer (ethanol–water: 1/5, v/v) at biological pH over other competitive ions through the proton transfer followed by hydrogen bond formation and subsequent anion coordination to yield the [LHSO4]LH+$3H2O (2) ensemble, which has been crystallographically characterised to ensure the structure property relationship. This non-cytotoxic HSO4 ion selective biomarker has great potential to recognize the intercellular distribution of HSO4 ions in HeLa cells under fluorescence microscope
Effect of substituents on FRET in rhodamine based chemosensors selective for Hg2+ ions
No full textThe effect of substituents on FRET in two newly designed rhodaminebased
Hg2+ ion selective chemosensors (L1 and L2) has been explored
by a systematic experimental and theoretical study. Comparison of
these sensors in the analytical study and imaging of Hg2+ ions in living
cells has also been included
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