3,263 research outputs found
Gastroenterologist against the machine - opportunities and limitations of machine learning models for prediction of advanced adenoma
No full textBackground & Aims Screening for colorectal cancer (CRC) relies on colonoscopy and/or fecal occult blood test while other (non-invasive) risk-stratification systems have not been implemented into European guidelines. Here, we evaluated the potential of Machine Learning (ML) methods to optimize prediction of advanced adenoma (AA).
Patients & Methods 5862 individuals participating in a screening program for colorectal cancer were included after excluding patients with history of CRC, symptomatic patients and those with insufficient colonoscopy. Adenoma were diagnosed histologically with AA being ≥1cm in size, or high-grade dysplasia/ villous features being present. Clinical, laboratory and lifestyle parameters were assessed at the time of colonoscopy. Logistic regression (LR) and extreme gradient boosting algorithms (XGBoost) were evaluated for AA-prediction based on readily-available laboratory/clinical/lifestyle parameters. The dataset was divided into a derivation cohort (for model development and internal cross-validation) and an external validation cohort.
Results The mean age was 58.7±9.7 years with 2811 males (48.0 %). 1404 (24.0 %) suffered from obesity (BMI≥30kg/m2), 871 (14.9 %) from diabetes, and 2095 (39.1 %) from the metabolic syndrome. Any adenoma was detected in 1884 (32.1 %) and any AA in 437 (7.5 %). 659 individuals (11.2 %) had a first-degree relative with a history of CRC. Modelling 36 laboratory parameters, 8 clinical parameters and data on 8 food types/dietary patterns, a moderate accuracy to predict AA with XGBoost (AUC of 0.66-0.68) and LR (AUC of 0.65-0.66) could be achieved. Limiting variables to established risk factors for AA did not significantly improve performance. Also, subgroup analyses in subjects without genetic predisposition or gender-specific analyses showed similar results.
Conclusion ML, based on point prevalence laboratory and clinical information, does not accurately predict AA. Non-invasive risk-prediction seems insufficient to replace current CRC screening programs. However, the potential for sequential application before colonoscopy to increase pre-test probability warrants further investigation
Georg Hermann.
No full textThe internationally renowned author of numerous novels, essays, and articles, Georg Hermann, was born as Georg Borchardt in Berlin-Friedenau on October 7, 1871, the youngest of six children in a well-established Jewish family. Later in life he used his father’s first name Hermann as his surname when writing. Contrary to the expectations for a young man from a reputable family, Hermann did not pursue the Abitur exam in a Gymnasium (secondary school), but instead received a one-year certificate in 1890, leaving school to become an apprentice salesman at a tie company. From 1896 until 1899 he worked in the Statistical Office of Berlin, at the same time attending literature and art history lectures at the University of Berlin. Afterwards he worked as a freelance writer and art critic.His first book, 'Spielkinder', was published in 1896, but he did not become well-known until 1906, with the publication of 'Jettchen Gebert', followed by its sequel, 'Henriette Jacoby'. These novels told the story of the life of a young woman living in Jewish Berlin during the Biedermeier period of the 1820s and 1830s. Politically active, Georg Hermann was also a member of the Central-Verein deutscher Staatsbürger jüdischen Glaubens.Having become known for his pacifist tendencies through his writing, and because of his Jewish heritage, Georg Hermann and his family fled to Holland shortly after the burning of the Reichstag in 1933. Although the rest of his family was saved from the Nazis after their occupation of Holland in 1943, Georg Hermann was sent to the Dutch concentration camp of Westerbork. On November 16, 1943 he was transported to Auschwitz and either died during transport or shortly after his arrival.Digital ImageRecord added to DigiTool. Aleph record suppressed. J. Palmisano 09/15/2010
Sammlung von Merckwürdigkeiten der Natur und Alterthümern des Erdbodens, welche petrificirte Cörper enthält
No full textaufgewiesen und beschrieben von Georg Wolffgang KnorrVorlageform des Erscheinungsvermerks: Nürnberg, zu finden bey dem Author. Gedruckt bey Andreas Bieling
Machine Learning Models Cannot Replace Screening Colonoscopy for the Prediction of Advanced Colorectal Adenoma
Get PDFScreening for colorectal cancer (CRC) continues to rely on colonoscopy and/or fecal occult blood testing since other (non-invasive) risk-stratification systems have not yet been implemented into European guidelines. In this study, we evaluate the potential of machine learning (ML) methods to predict advanced adenomas (AAs) in 5862 individuals participating in a screening program for colorectal cancer. Adenomas were diagnosed histologically with an AA being ≥ 1 cm in size or with high-grade dysplasia/villous features being present. Logistic regression (LR) and extreme gradient boosting (XGBoost) algorithms were evaluated for AA prediction. The mean age was 58.7 ± 9.7 years with 2811 males (48.0%), 1404 (24.0%) of whom suffered from obesity (BMI ≥ 30 kg/m2), 871 (14.9%) from diabetes, and 2095 (39.1%) from metabolic syndrome. An adenoma was detected in 1884 (32.1%), as well as AAs in 437 (7.5%). Modelling 36 laboratory parameters, eight clinical parameters, and data on eight food types/dietary patterns, moderate accuracy in predicting AAs with XGBoost and LR (AUC-ROC of 0.65–0.68) could be achieved. Limiting variables to established risk factors for AAs did not significantly improve performance. Moreover, subgroup analyses in subjects without genetic predispositions, in individuals aged 45–80 years, or in gender-specific analyses showed similar results. In conclusion, ML based on point-prevalence laboratory and clinical information does not accurately predict AAs
Georg Trakl and melancholy
No full textThis paper identifies some of the decisive aspects of Georg Trakl’s poetry, taking as the starting point the author’s awareness about God’s death, from Nietzsche’s approach. Emphasis is placed on melancholy, support of the creation, testimony and acknowledgement of failure and grief of mankind, from which the author was able to express his discouragement upon the downfall and decline of the West.Se identificaron algunos aspectos determinantes de la obra poética de Georg Trakl, tomando como punto de partida la conciencia del escritor acerca de la muerte de Dios, desde la perspectiva de Nietzsche. Se hizo un énfasis sobre la melancolía, soporte de la creación, testimonio y reconocimiento del errar y el duelo del hombre, a partir de la cual el autor pudo expresar el desconsuelo por la ruina y el ocaso de Occidente
Tractatio Jvridica De Concursu Novercæ Cum Privignis
No full textZugl.: Basel, Univ., Jur. Diss., 1728[Hermann Georg Krohn]A new edition, revised by the author, of his inaugural dissertation, Basel, 1728, published by G.C. Overbeck, with a conspectus of the chapters. Cf. prefIncludes bibliographical referencesWith: Rösener, Andreas Christoph. Andreae Christophori Röseneri j.u.d. Tractatus juridicus de libris mercatorum. Lipsiae : Sumptibus haeredum Friderici Lanckisii, literis Christiani Scholvini, [1694]. Copy 2. Bound together subsequent to publicationAutopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Lubecæ, Sumtibus Jonae Schmidt. MDCCXLVII
UEG900820 Supplemental Material - Supplemental material for Novel reliability criteria for controlled attenuation parameter assessments for non-invasive evaluation of hepatic steatosis
No full textSupplemental material, UEG900820 Supplemental Material for Novel reliability criteria for controlled attenuation parameter assessments for non-invasive evaluation of hepatic steatosis by Georg Semmler, Katharina Wöran, Bernhard Scheiner, Lukas Walter Unger, Rafael Paternostro, Judith Stift, Philipp Schwabl, Theresa Bucsics, David Bauer, Benedikt Simbrunner, Albert Friedrich Stättermayer, Matthias Pinter, Michael Trauner, Thomas Reiberger and Mattias Mandorfer in United European Gastroenterology Journal</p
Sammlung von Merckwürdigkeiten der Natur und Alterthümern des Erdbodens, welche petrificirte Cörper enthält / aufgewiesen und beschrieben von Georg Wolffgang Knorr
No full textVorlageform des Erscheinungsvermerks: Nürnberg, zu finden bey dem Author. Gedruckt bey Andreas Bieling
Letter containing inquiry regarding the ethnic identity of the descendents of Georg Moritz Oppenheim.
No full textLetter from Wilhelm Gehlig to Rabbi Dr. Freudenthal in Nuremberg with a genealogical question regarding Georg Moritz Oppenheim. Of particular interest to the author is to determine whether Oppenheim's descendents are "rein jüdischen Blutes (=of pure Jewish blood)."Robert Singermandigitize
Georg Simmel
No full textThe chapter about Georg Simmel stands as an innovative sociological research that introduces the study of emotions through a detailed examination of the theory and concepts of one of the classical author of discipline
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