1,721,103 research outputs found
CHANGES IN THE COAGULATION-FIBRINOLYSIS BALANCE OF ENDOTHELIAL-CELLS AND MONONUCLEAR PHAGOCYTES - ROLE IN DISSEMINATED INTRAVASCULAR COAGULATION ASSOCIATED WITH INFECTIOUS-DISEASES
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Complement-dependent and complement-independent interactions of bacterial lipopolysaccharides and mucopeptides with rabbit and human platelets.
No full textReduction of the plasma levels of tissue plasminogen activator after infusion of a lipid emulsion in humans
No full textThrombin Activatable Fibrinolysis Inhibitor: at the nexus of fibrinolysis and inflammation
No full textTAFI (thrombin activatable fibrinolysis inhibitor) is the precursor of a basic carboxypeptidase (TAFIa) with strong antifibrinolytic and anti-inflammatory activity. Compelling evidence indicates that thrombin, either alone or in complex with thrombomodulin, is the main physiological activator of TAFI. For this reason derangements of thrombin formation, whatever the cause, may influence the fibrinolytic process too. Experimental models of thrombosis suggest that TAFI may participate in thrombus development and persistence under certain circumstances. In several models of pharmacological thrombolysis, the administration of TAFI inhibitors along with the fibrinolytic agent leads to a marked improvement of thrombus lysis, underscoring the potential of TAFI inhibitors as adjuvants for thrombolytic therapy. The role of TAFI in inflammatory diseases is more complex as it may serve as a defense mechanism, exacerbate the disease, or have no influence, depending on the nature of the model and the role played by the mediators controlled by TAFIa. Finally, the numerous clinical studies in patients with thrombotic disease support the idea that increased levels of TAFI and/or the enhancement of TAFI activation may represent a new risk factor for venous and arterial thrombosis
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