1,720,983 research outputs found
Rapporto tra danno alla salute e danno all' attività produttiva di reddito: spunti casistici.
No full text
Il danno biologico e le piccole invalidità: saggio su alcune differenze sistematiche fra tabelle per la valutazione del danno alla persona. In: Introna F, Rodriguez D (a cura di) "Le piccole invalidità permanenti in responsabilità civile: valutazione medico- legale e costo economico".
No full text
Il danno biologico e le piccole invalidità: saggio su alcune differenze sistematiche fra tabelle per la valutazione del danno alla persona.
No full text"State-of-Art" paper of the Italian Working Group on Atherosclerosis: Preclinical assessment of early coronary atherosclerosis
No full textAlthough the early diagnosis and treatment for acute myocardial infarction have improved over the past decades, the morbidity and mortality from coronary artery disease (CAD) remain significant in Europe and worldwide. It is estimated that the majority of people in the developed countries who die suddenly from CAD, have no prior manifestation of disease, and the majority of these individuals are not considered to be at high risk. Accurate identification of individuals at risk of such events before the clinical manifestations is therefore required. This "State-of-Art" paper of the Italian Working Group on Atherosclerosis aims to i. provide an overview of both the traditional and emerging non-invasive imaging techniques used to detect early atherosclerosis in the general population with moderate cardiovascular risk; ii. identify the rationale for screening asymptomatic patients with preclinical atherosclerotic lesions and the optimal algorithm that should be used to detect them; iii. discuss the future directions of atherosclerosis research, with special focus on nanotechnology, aimed at early identification and treatment of low- and intermediate-risk patients
Uncovering quorum sensing and quenching structural properties: a systems biology approach
No full textBacteria have the ability to coordinate their behavior in a cell density-dependent manner by using diffusible signal molecules. The mechanism, known as quorum sensing, is a cell-to-cell communication process exploited either by pathogens to regulate the expression of virulence and antimicrobial resistance-related genes and by synthetic biologists to engineer bacterial density-dependent functions. Using a systems biology approach, we developed a novel quorum sensing mathematical model and performed a comprehensive study of the equilibrium properties of this communication process. This analysis highlighted crucial structural properties as a result of bistability in the genetic circuit and underlined that bacteria exploit feedback control strategies to produce a unified and robust response. Due to increased antibiotic-resistant infections, researchers investigated enzymatic methods to interfere with quorum sensing. In this paper, we simulated two quorum quenching strategies. Using a modeling approach, we discovered core parameter values which guarantee the effectiveness of these strategies and could be exploited in rational design of synthetic biology based engineered bacteria
- …
