26 research outputs found
Composition of the essential oils in various organs at different developmental stages of Ammi visnaga (L.) Lam. from Tunisia
No full textThe composition of the essential oils isolated by hydrodistillation from various organs at different development stages of Ammi visnaga (L.) Lam. growing in Tunisia was determined by GC/MS analysis. In particular, the oil profiles of the leaves, stems, flower buds, roots, umbels, and fruits have been examined during the whole life cycle. The oil from the flowering aerial parts was characterized by a high content of isoamyl 2-methylbutanoate. After flowering and during desiccation and fructification, the umbels and fruits expressed a high content of linalool. The oils, extracted from the roots collected in the vegetative, buds floral, and floral stages, were rich in monoterpene aldehydes, oxygenated monoterpenes, and monoterpene hydrocarbons. The highest level of non-terpene hydrocarbons was found at the flowerbud stage, represented by 61.3% of nonane. Among the monoterpenes, sabinene (12.5%) and β-pinene (8.5%) were identified in the flower buds
Complications orbitaires de la polypose nasosinusienne de l’enfant
No full textLa polypose nasosinusienne (PNS) est une pathologie rare chez l’enfant. La symptomatologie clinique est habituellement celle de l’adulte. Exceptionnellement, une complication locorégionale lui est révélatrice. A travers deux observations de PNS diagnostiquées suite à une complication orbitaire, on discute les particularités cliniques de cette entité ainsi que ses implications thérapeutiques. Il s’agissait de deux enfants âgés de 13 ans ayant été hospitalisés pour une exophtalmie unilatérale d’apparition aiguë. L’examen clinique a découvert une PNS surinfectée évoquant alors le diagnostic de complication orbitaire d’origine infectieuse, confirmé par l’imagerie. Le traitement a associé un drainage chirurgical d’urgence de l’abcès orbitaire par voie externe paracanthale interne, suivi par une corticothérapie locale. L’ethmoïdectomie a été nécessaire dans un cas. L’évolution était favorable dans les deux cas avec une stabilisation de la PNS et une absence de signes de récidive de l’infection orbitaire
Micro-analysis as a Tool for the Characterization of Historical Masonry Buildings: The Decorative Elements of the Basilica Della Beata Vergine Maria Del Rosario (Polesella, Rovigo)
No full textThe Basilica of the Beata Vergine Maria del Rosario of Polesella, the subject of this study, was built in the mid-eighteenth century in the village of Polesella (in the province of Rovigo, Veneto Region, Italy). Some restoration work on the Basilica has been necessary for recent years; this has allowed sampling of interior plasters on which preliminary microanalyses have been performed to better characterize the building materials used, in support of subsequent repair work. Among the many planned restoration works, interventions on the interior walls were, in addition, also planned. For this, the interior plasters and interior painting of the church were studied through observations with SEM–EDS. The objective of this work is mainly to show how archeometric analyses can be a valuable tool to improve the knowledge and characterization of the materials used, in this case, on some decorative elements of the Basilica. In particular, regarding the frescoes, the research was also aimed at identifying the type of pigments used by the author Luigi Battisti, believed to be the author of some of the works on display
Impact diagnostique du dépôt isolé des fractions du complément au niveau de la jonction dermo-épidermique en immunofluorescence directe cutanée
No full text
Renal epithelioid angiomyolipoma: 2 Cases report
No full textIntroduction: The 2004 World Health Organization Classification of Renal Neoplasms defined epithelioid angiomyolipoma as a potentially malignant mesenchymal neoplasm, characterized by a proliferation of predominantly epithelioid cells with approximately one third of patients experiencing metastases and one half of them having a history of tuberous sclerosis complex.
Observations: We report two cases of renal epithelioid angiomyolipoma diagnosed at our institution in order to analyze their clinical behaviour and histopathological features, and insist on diagnostic pitfalls.
Conclusion: Renal tumours with certain unusual features should be investigated immunohistochemically to exclude the possibility of epithelioid angiomyolipoma. These tumours are more likely to have an aggressive behaviour when they show more morphologic features predicting malignancy
Anxiety and depression among patients with chronic sciatica
No full textIntroduction
Spinal radicular syndromes are currently a significant healthcare concern in society. A common manifestation of these syndromes is sciatic pain, characterized by severe pain radiating along the course of the sciatic nerve. In many patients, chronic pain can lead to psychological problems.
Objectives
The aim of this study was to assess the frequency of anxiety and depression disorders in patients with sciatica and their impact on functional capacity.
Methods
We conducted a cross-sectional study, including patients suffering from documented common sciatic pain evolving for more than 3 months. The study was conducted in a rheumatology department over a period of 3 years. We used the Hospital Anxiety and Depression Scale (HADS) questionnaire, supplemented with information about the study group, pain location, and patients’ occupations. Additionally, the Oswestry Disability Index (ODI) and the Visual Analog Scale (VAS) were applied.
Results
The study included 104 patients (71 women and 33 men, with a male-to-female sex ratio of 0.46). The mean age of our patients ranged from 23 to 74 years. The most frequent etiology of sciatic pain was a herniated disc, followed by lumbar spinal stenosis and spondylolisthesis. The root path was L5 in 74 cases and S1 in 30 cases. The average duration of sciatic pain was 6.4 months. The mean Oswestry score was 25 (ranging from 15 to 38). The mean VAS score was 7.4 (ranging from 4 to 9). The mean Work Ability Index (WAI) was 25.2 (ranging from 15 to 38).
Depression was noted in 53 patients (50.9%) with a mean HADS depression score of 10.8 (ranging from 4 to 16). Anxiety was noted in 8 patients (7.6%) with a mean HADS anxiety score of 6.40 (ranging from 3 to 16). In univariate analysis, anxiety was associated with the low educational level of patients and with the duration of sciatic pain (p 0.05).
Conclusions
Among patients with sciatic pain, there is a high prevalence of psychiatric disorders, including anxiety and depression. Regular screening for these disorders should be conducted by healthcare providers.
Disclosure of Interest
None Declare
A Shotgun Proteomic-Based Approach with a Q-Exactive Hybrid Quadrupole-Orbitrap High-Resolution Mass Spectrometer for the Assessment of Pesticide Mixture-Induced Neurotoxicity on a 3D-Developed Neurospheroid Model from Human Brain Meningiomas: Identification of Trityl-Post-Translational Modification
No full textThe widespread use of pesticides, particularly in combinations, has resulted in enhanced hazardous health effects. However, little is known about their molecular mechanism of interactions. The aim of this study was to assess the neurotoxicity effect of pesticides in mixtures by adopting a 3D in vitro developed neurospheroid model, followed by treatment by increased concentrations of pesticides for 24 h and analysis by a shotgun proteomic-based approach with high-resolution tandem mass spectrometry. Three proteins, namely, glyceraldehyde-3-phosphate-dehydrogenase (GAPDH), α-enolase, and phosphoglycerate-kinase-1, were selected as key targets in the metabolic process. Only high doses of pesticides mitigated cell-density proliferation with the occurrence of apoptotic cells, which unlikely makes any neurological alterations in environmental regulatory exposures. The proteomic analysis showed that majority of altered proteins were implicated in cell metabolism. De novo peptide sequencing revealed ion losses and adduct formation, namely, a trityl-post-translational modification in the active site of 201-GAPDH protein. The study also highlights the plausible role of pyrethroids to be implicated in the deleterious effects of pesticides in a mixture. To the best of our knowledge, our finding is the first in toxicoproteomics to deeply elucidate pesticides’ molecular interactions and their ability to adduct proteins as a pivotal role in the neurotoxicity mechanism
