99 research outputs found
sj-docx-1-opp-10.1177_10781552231203703 - Supplemental material for Cabozantinib-induced heart failure
No full textSupplemental material, sj-docx-1-opp-10.1177_10781552231203703 for Cabozantinib-induced heart failure by Serhat Sekmek, Dogan Bayram, Gokhan Ucar, Burak Civelek, Fahriye Tugba Kos and Dogan Uncu in Journal of Oncology Pharmacy Practice</p
Renal Transplantasyon Yapılan Hastalarda Diyare Yan Etkisi Sebebiyle Mikofenolattan Azatioprine Geçilmesinin Etkinlik ve Güvenliği
No full textSekmek S, Efficacy and Safety of Switching from Mycophenolate to Azathioprine in Renal Transplant Patients Due to Diarrhea Side Effect. Thesis in Internal Medicine, Ankara, 2020. Mycophenolate is a commonly used immunosuppressive drug after renal transplantation. Diarrhea is one of the most common side effects of mycophenolate treatment in clinical practice. In patients with drug-induced diarrhea under mycophenolate treatment, one of the options is to switch from mycophenolate to azathioprine. In this study, we aimed to investigate the effect of switch from mycophenolate to azathioprine on amelioration of diarrhea complaints and the risks on rejection and graft and patient survival. A total of 177 patients, 59 of whom were switched to azathioprine and 118 of which were control group, participated in this study. Basal glomerular filtration rate was lower in the patients who were switched to azathioprine than the control group (p <0.0001); basal creatinine (p = 0.001) and basal proteinuria (p = 0.004) values were higher than the control group. It was observed that 89.8% of the patients who switched to azathioprine due to diarrhea had improved diarrhea complaints. It was shown that 83.3% of the patients whose diarrhea complaints did not improve despite switching to azathioprine had a diagnosis of amyloidosis. Patients that received azathioprine had more graft loss than patients continued mycophenolate (p = 0.004). Particularly in patients with a glomerular filtration rate of less than 30 ml/min at the time of conversion, the risk of graft loss increased after switching from mycophenolate to azathioprine due to diarrhea. In conclusion for selected patients, discontinuation of mycophenolate treatment due to diarrhea and initiation of azathioprine treatment was found to be an effective approach to improve diarrhea complaints.Sekmek S., Renal Transplantasyon Yapılan Hastalarda Diyare Yan Etkisi Sebebiyle Mikofenolattan Azatioprine Geçilmesinin Etkinlik Ve Güvenliği. Hacettepe Üniversitesi İç Hastalıkları Uzmanlık Tezi, Ankara, 2020. Mikofenolat, renal transplantasyon sonrasında sık kullanılan bir immunsupresif ilaçtır. Mikofenolat tedavisinin klinik pratikte en sık karşılaşılan yan etkilerinden birisi ishaldir. Mikofenolat tedavisi altında ilaca bağlı ishal gelişen hastalarda, azatioprin tedavisine geçilmesi alternatif yollardan birisidir. Çalışmamızda ishal sebebiyle mikofenolat tedavisi kesilerek azatioprin tedavisi başlanan hastaların, tedavi değişikliği sonrasında ishal şikayetinde ne oranda düzelme olduğunun ve bu tedavi değişikliğinin rejeksiyon gelişimi ve greft ve hasta sağ kalımına etkisinin araştırılması planlanmıştır. Çalışmaya 59’u azatioprine geçilen gruptan, 118’i kontrol grubundan olmak üzere toplam 177 hasta katılmıştır. Çalışmaya katılan hastalardan, azatioprine geçilen gruptaki bazal glomerüler filtrasyon hızının, kontrol grubuna göre daha düşük olduğu (p < 0,0001); bazal kreatinin (p = 0,001) ve bazal proteinüri (p = 0,004) değerlerinin kontrol grubuna göre daha yüksek olduğu saptanmıştır. İshal sebebiyle azatioprine geçilen hastaların %89,8’inde ishal şikayetinin düzeldiği gözlenmiştir. Azatioprine geçilmesine rağmen ishal şikayeti düzelmeyen hastalar incelendiğinde, hastaların %83,3’ünün amiloidoz tanılı hastalar olduğu görülmüştür. Çalışmamızın sonucunda, azatioprin kullanan hastalarda, mikofenolat kullanan hastalara göre daha çok greft kaybı olduğu gözlenmiştir (p = 0,004). Özellikle glomerüler filtrasyon hızı 30 ml/dk’nın altında olan hastalarda, ishal sebebiyle mikofenolattan azatioprine geçiş yapıldığında, greft kaybı riskinin arttığı gözlenmiştir. Uygun hastalarda, ishal sebebiyle mikofenolat tedavisinin kesilip azatioprin tedavisine başlanmasının, ishal şikayetinin düzelmesinde etkili bir yaklaşım olduğu saptanmıştır
Comparing clusterings and numbers of clusters by aggregation of calibrated clustering validity indexes
No full textAkhanli, Serhat Emre/0000-0001-7173-3277WOS: 000543319300001A key issue in cluster analysis is the choice of an appropriate clustering method and the determination of the best number of clusters. Different clusterings are optimal on the same data set according to different criteria, and the choice of such criteria depends on the context and aim of clustering. Therefore, researchers need to consider what data analytic characteristics the clusters they are aiming at are supposed to have, among others within-cluster homogeneity, between-clusters separation, and stability. Here, a set of internal clustering validity indexes measuring different aspects of clustering quality is proposed, including some indexes from the literature. Users can choose the indexes that are relevant in the application at hand. In order to measure the overall quality of a clustering (for comparing clusterings from different methods and/or different numbers of clusters), the index values are calibrated for aggregation. Calibration is relative to a set of random clusterings on the same data. Two specific aggregated indexes are proposed and compared with existing indexes on simulated and real data.EPSRCEngineering & Physical Sciences Research Council (EPSRC) [EP/K033972/1]The work of the second author was supported by EPSRC grant EP/K033972/1
Classification of juvenile myoclonic epilepsy data acquired through scanning electromyography with machine learning algorithms
No full textOsman, Onur (Arel Author), Özekes, Serhat (Arel Author)In this paper, classification of Juvenile Myoclonic Epilepsy (JME) patients and healthy volunteers included into Normal Control (NC) groups was established using Feed-Forward Neural Networks (NN), Support Vector Machines (SVM), Decision Trees (DT), and Na < ve Bayes (NB) methods by utilizing the data obtained through the scanning EMG method used in a clinical study. An experimental setup was built for this purpose. 105 motor units were measured. 44 of them belonged to JME group consisting of 9 patients and 61 of them belonged to NC group comprising ten healthy volunteers. k-fold cross validation was applied to train and test the models. ROC curves were drawn for k values of 4, 6, 8 and 10. 100% of detection sensitivity was obtained for DT, NN, and NB classification methods. The lowest FP number, which was obtained by NN, was 5
Political Endowments and Electricity Market Regulation in Turkey: An Institutional Analysis
Get PDFTurkey has been going through a liberalization process in its electricity market over the last decade. So far, the regulatory content of the market reforms has been in the center of attention in the literature, to the negligence of regulatory governance. However, recent studies, which applied the theoretical insights of new institutional economics to utilities regulation, have demonstrated that political endowments of the country draw the boundaries to which extent such regulatory content can be effectively implemented. In line with these studies, this paper adopts an institutional approach and attempts to identify the political endowments of Turkey in order to further analyze whether the market reforms succeeded in bringing about sufficient checks to cure the institutional problems. In other words, the paper takes a picture of the overall regulatory arena. The results show that the current regulatory structure, especially government-regulator relations, fails to meet good regulatory governance criteria. The paper also provides some policy suggestions.electricity regulation; regulatory governance; institutions
Reflections on methodology for assessing campus sustainability from a Turkish perspective
No full textAim: The author provides a critical reflection of the questionnaire discussed at the workshop “Methodology for assessing the campus sustainability from the perspective of multi-level antifragility” held on Friday 13 May at the WSB University in Wrocław. The author reflects from the background of his experience in Turkey. Design / Research methods: The author provides his own reflections and opinions, based on the discussions at the workshop. Conclusions / findings: It is very difficult to create a set of indicators making campus sustainability internationally comparable, as well as finding proper sources of information. A starting point in creating such indicators may be mistakes threatening organizational viability and external sustainability Originality / value of the article: The article provides critical feedback on an innovative approach towards research on campus sustainability. </jats:p
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Session B6: Hydraulic Design of an Innovative Baffle-Brush Type Fish Pass
No full textPresenting Author Bio: Dr. Serhat Kucukali completed his MSc and PhD degrees in Hyraulic Engineering at the Istanbul Technical University. He was a Post-doc fellow in the Civil Engineering Department of University of Queensland in Australia. He has published more than 40 research papers and his work was cited over 200 times. He has been conducting research on hydropower, environmental hydraulics, and sustainability. He developed an Environmental Risk Index for Small Hydropower Plants.Abstract: The flow characteristics (depth, velocity, energy dissipation) of a new baffle-brush type fish pass were investigated experimentally in a 2 m wide rectangular flume which has a bed slope of 4% for discharges ranging between100-550 L/s. In all experiments quasi-uniform and subcritical flow conditions, Froude number ranging between 0.17-0.23, were observed. The Darcy-Weisbach friction factor was negatively correlated with the relative submergence of the baffle. The turbulence intensities were ranged between %38-79 in the baffle zone and %13-31 in the brush zone. The hydraulic test results showed that this type of fish pass can produce adequate flow depth and favorable local flow velocities for the design discharge of 0.2 m2/s (relative submergence of brushes=1.03). The hydraulic test results reveal that baffle-brush fish pass fulfill the requirements of an efficient fish passage by providing tranquil flows and sufficient flow depths for different fish species. Consequently, the following design procedure can be used for the proposed baffle-brush fish pass: (i) required flow depth can be specified for the target fish species, (ii) the friction factor can be estimated based on the relative submergence of baffle, and (iii) for the given bed slope, average flow velocity and discharge values can be computed from Darcy-Weisbach formula. The main advantage of the proposed hydraulic design is that we can scale-up all the parts of this type in order to adjust it to almost any demand based on the model test results
A simulation study for determination of refractive index dispersion of dielectric film from reflectance spectrum by using Paul wavelet
No full text32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEYIn this work, the Continuous Wavelet Transform (CWT) with Paul wavelet was improved as a tool for determination of refractive index dispersion of dielectric film by using the reflectance spectrum of the film The reflectance spectrum was generated theoretically in the range of 0.8333 - 3.3333 mu m wavenumber and it was analyzed with presented method. Obtained refractive index determined from various resolution of Paul wavelet were compared with the input values, and the importance of the tunable resolution with Paul wavelet was discussed briefly. The noise immunity and uncertainty of the method was also studied.Turkish Phys So
An improved method for determination of refractive index of absorbing films: A simulation study
No full text32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEYIn this work an improved version of the method presented by Gandhi was presented for determination of refractive index of absorbing films. In this method local maxima of consecutive interference order in transmittance spectrum are used. The method is based on the minimizing procedure leading to the determination of interference order accurately by using reasonable Cauchy parameters. It was tested on theoretically generated transmittance spectrum of absorbing film and the details of the minimization procedure were discussed.Turkish Phys So
Conducting Democratic Evaluations where Democratic Principles are not always Practiced
Get PDFBackground: Turkey is a fast-developing country facing a lot of different problems. One of the problems is inadequate education. A large project was started to improve Turkish elementary education. The project includes many different purposes from physical refurbishment of school buildings, to increasing technology use in education. The author of this paper carried out a democratic study to evaluate this project. This article reports on what was learned from this evaluation study conducted in Turkey. Purpose: The purpose of this article is to examine how democratic evaluations can be used to help understand the complex realities where undemocratic ideology has a long history. Setting: This evaluation study was conducted in an elementary school from a lower-middle class neighborhood
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