86,629 research outputs found

    Cavernous sinus metastasis in head and neck cancer: Focus on oral squamous cell cancer

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    Intracranial metastatic disease is rarely found in head and neck cancer (HNC), in particular, cavernous sinus (CS) involvement is difficult to recognize, because of its rarity, not specific symptoms associated and challenging imaging features. We report our experience in 4 cases, reviewing also the English literature. We analysed data from 21 patients showing that CS metastasis is a dramatic event, with rapid onset, usually starting with neurological manifestations (ophthalmoplegia, headache and trigeminal dysesthesia) and almost unavoidable outcome (DOD in 18/21 patients). Furthermore, we assessed that the diagnostic confirmation could be difficult to perform because of the need for multiple exams and time consuming procedures. Unfortunately, usual antineoplastic therapies seem to be not effective in prolonging survival, also because patients are already weakened by primary tumour treatments. The only option that seems useful in improving outcomes is immunotherapy

    A LiDAR based analysis of hydraulic hazard mapping

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    Mapping hydraulic hazard is a ticklish procedure as it involves technical and socio-economic aspects. On the one hand no dangerous areas should be excluded, on the other hand it is important not to exceed, beyond the necessary, with the surface assigned to some use limitations. The availability of a high resolution topographic survey allows nowadays to face this task with innovative procedures, both in the planning (mapping) and in the map validation phases. The latter is the object of the present work. It should be stressed that the described procedure is proposed purely as a preliminary analysis based on topography only, and therefore does not intend in any way to replace more sophisticated analysis methods requiring based on hydraulic modelling. The reference elevation model is a combination of the digital terrain model and the digital building model (DTM+DBM). The option of using the standard surface model (DSM) is not viable, as the DSM represents the vegetation canopy as a solid volume. This has the consequence of unrealistically considering the vegetation as a geometric obstacle to water flow. In some cases the topographic model construction requires the identification and digitization of the principal breaklines, such as river banks, ditches and similar natural or artificial structures. The geometrical and topological procedure for the validation of the hydraulic hazard maps is made of two steps. In the first step the whole area is subdivided into fluvial segments, with length chosen as a reasonable trade-off between the need to keep the hydrographical unit as complete as possible, and the need to separate sections of the river bed with significantly different morphology. Each of these segments is made of a single elongated polygon, whose shape can be quite complex, especially for meandering river sections, where the flow direction (i.e. the potential energy gradient associated to the talweg) is often inverted. In the second step the segments are analysed one by one. Therefore, each segment was split into many reaches, so that within any of them the slope of the piezometric line can be approximated to zero. As a consequence, the hydraulic profile (open channel flow) in every reach is assumed horizontal both downslope and on the cross-section. Each reach can be seen as a polygon, delimited laterally by the hazard mapping boundaries and longitudinally by two successive cross sections, usually orthogonal to the talweg line. Simulating the progressive increase of the river stage, with a horizontal piezometric line, allow the definition of the stage-area and stage-volume relationships. Such relationships are obtained exclusively by the geometric information as provided by the high resolution elevation model. The maximum flooded area resulting from the simulation is finally compared to the potentially floodable area described by the hazard maps, to give a flooding index for every reach. Index values lower than 100% show that the mapped hazard area exceeds the maximum floodable area. Very low index values identify spots where there is a significant incongruity between the hazard map and the topography, and where a specific verification is probably needed. The procedure was successfully used for the validation of many hazard maps across Italy

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Replica-guided trauma surgery

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    The aim of this study is to present a new approach to the surgical treatment of fractures of the middle third of the face, based on the use of resorbable materials and stereolithographic models. From 2009 to 2014, we treated 10 cases of orbitozygomatic trauma mostly as secondary surgery. For each case, an anatomical replica had been produced simulating the expected result and was then used to contour the resorbable plates on its surface, even before the beginning of the surgical procedure itself. The plates and meshes already bended act as a guide to bony reduction procedure. No complications occurred: all patients healed well, without inflammatory reactions. The results obtained corresponded to the expected results. This technique has been employed for primary or secondary treatment of fracturesof the middle third facial, where it is not always easy to understand the displacement of bony segments and where the use of resorbables plates could be particularly beneficial, as they do not interfere with the maxillofacial skeleton physiology and avoid the necessity to remove plates and screws. Combined use of stereolithographic model and resorbable materials allow a new surgical approach based on the realization of the surgical procedure on the model, then transferred from the patient to the model, thanks to plates and meshes. This technique helps to overcome many of the limits of the conventional technique: the need of minimal surgical access, in order to minimize facial scarring and the vasculo-nervous structures that cross the head and neck district and the obligation to restore not only the morphology but also the biological functions

    Bidirectional flux of fluids & microbiota at implant-Abutment connection of FMD storm implant system: An in vitro study using RT-PCR

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    The purpose of the present microbiological study was to evaluate bacterial leakage at implant-Abutment connection level of a new type of implant (Storm implant (FMD, Falappa Medical Devices®, Rome, Italy) using Real-Time Polymerase Chain Reaction (RT-PCR). This implant presents a polygonal external implant-Abutment connection with a geometry that provides a hex on which engage complementary abutments. To identify the capability of the implant to protect the internal space from the external environment, the passage of genetically modified Escherichia coli across implant-Abutment interface was evaluated. Four Storm implants (FMD, Falappa Medical Devices®, Rome, Italy) were immerged in a bacterial culture for 24 h and bacteria amount was measured inside implant-Abutment interface with Real-Time PCR. Bacteria were detected inside all studied implants, with a median percentage of 15% for P. gingivalis and 14% for T. forsythia. Our results are similar to those reported in the English literature. Additional studies are needed to explore the relationship in terms of microbiota between the internal implant and implant-prosthetic connection. In addition, the dynamics of internal colonization needs to be thoroughly documented in longitudinal in vivo studies. As a result, microbial leakage along the implant abutment interface was acceptable and considered the most probable explanation for peri-implantitis

    [Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]

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    Newspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.

    Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation

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    The desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters

    John F. Kennedy telegram to Roosevelt

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    Jersey Homesteads (later the Borough of Roosevelt) was established in the 1930s as an agro-industrial cooperative community. It was established specifically for urban Jewish garment workers, many of whom had emigrated from Europe. President John F. Kennedy sent a telegram to the citizens of Roosevelt, New Jersey, apologizing for not being able to attend the memorial dedication in honor of former President Franklin Delano Roosevelt. (Jersey Homesteads became Roosevelt in 1945 in honor of the president.) President Kennedy expressed his gratitude to the people of Roosevelt for constructing the memorial, and commented that it will serve as a constant reminder of Roosevelt's good works
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