4,206 research outputs found
Assessing risk of self-harm in acute paediatric settings: A multicentre exploratory evaluation of the CYP-MH SAPhE instrument
No full textOBJECTIVE: To psychometrically assess the Children and Young People-Mental Health Self-harm Assessment in Paediatric healthcare Environments (CYP-MH SAPhE) instrument for the identification of immediate risk of self-harm in CYP, aged 10-19 years, in acute paediatric wards or emergency departments., DESIGN: The CYP-MH SAPhE Instrument was developed through a robust scoping review and Delphi consensus with 30 clinicians/topic experts. To evaluate the psychometric properties, a multicentre exploratory study was conducted., SETTING: Three acute hospitals in the UK., PARTICIPANTS: 163 CYP presenting at acute hospital settings with primary mental health (cases) or physical health (non-cases) conditions., PRIMARY AND SECONDARY OUTCOME MEASURES: Psychometric properties of the CYP-MH SAPhE instrument were evaluated through Principle Axis Factoring (PAF) with Oblimin (Kaiser normalisation) alongside measures of internal consistency (Cronbach's alpha), convergent, discriminant and face validity., RESULTS: PAF of the dichotomous items (n=9) loaded onto three factors (1) behaviours and intentions; (2) suicidality and (3) self-harm. Factors 1 (Cronbach's alpha=0.960) and 3 (Cronbach's alpha=1) had high internal consistency. There was: good level of agreement between raters (kappa=0.65); a moderately positive correlation between the CYP-MH SAPhE instrument and the Columbia-Suicide Severity Rating Scale; and discrimination between cases and non-cases across the three factors (factor 1: m=88 vs 70; factor 2: m=102 vs 70; factor 3: m=104 vs 68). Assessment of face validity resulted in six items being removed, culminating in an eight question, rapid assessment instrument., CONCLUSIONS: The results support the CYP-MH SAPhE Tool as a potentially reliable and valid instrument to identify immediate risk of self-harm in CYP presenting to acute paediatric healthcare environments, which is a burgeoning and significant global health issue. Copyright © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.https://dx.doi.org/10.1136/bmjopen-2020-04376
Non-alloy Mg anode for Ni-MH batteries: Multiple approaches towards a stable cycling performance
No full textMg attracts much research interest as anode material for Ni-MH batteries thanks to its lightweight, cost-effectiveness and high theoretical capacity (2200 mA h g−1). However, its practical application is tremendously challenged by the poor hydrogen sorption kinetics, passivation from aggressive aqueous electrolytes, and insulating nature of MgH2. Mg-based alloys exhibit enhanced hydrogen sorption kinetics and electrical conductivity, but significant amount of costly transition metal elements are required. In this work, we have, for the first time, utilized non-alloyed but catalyzed Mg as anode for Ni-MH batteries. 5 mol.% TiF3 was added to nanosized Mg for accelerating the hydrogen sorption kinetics. Several strategies for preventing the problematic passivation of Mg have been studied, including protective encapsulation of the electrode and utilizing room-temperature/high-temperature ionic liquids and an alkaline polymer membrane as working electrolyte. Promising electrochemical performance has been achieved in this Mg–TiF3 composite anode based Ni-MH batteries with room for further improvements.</p
Evolutionary conservation of MH genes and interactions.
No full text<p>Human genes and interactions are classified as evolutionary conserved or non-conserved using inter-species conservation cutoff of 70% (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0036488#s4" target="_blank">Materials and Methods</a>) for human protein-coding genes (HomoloGene), protein and gene regulatory interactions (KEGG and Reactome). The p-values are based on Fisher exact test for enrichment of MH compared to non-MH genes or interactions. Enrichment is tested for all available protein-coding genes and/or protein interactions (All); for cell division and mitosis-focused genes and/or interactions from KEGG MIN (KEGG MIN); and for the regulatory genes and/or interactions from KEGG MIN (Regulatory KEGG MIN).</p
Impact of COVID-19 on mental health and lifestyle behaviours
No full textCOVID-19, an infectious disease that is highly contagious and health threatening, has drastically affected many people’s lives. This study sets out to explore the impact of the pandemic on the mental health (MH) and lifestyle behaviours (LB) of university students in Singapore. LB include physical activity (PA), eating behaviours (EB), sleep quality and online usage. First, the relationship between MH and LB was investigated using correlation analysis. Results revealed significant positive correlation between MH and sleep quality, and a significant negative correlation between MH and EB, as well as between MH and online usage. Consistent with the transactional model of stress and coping (Lazarus & Folkman, 1984), results from regression analyses showed that more negative perceptions of COVID-19 (NPC) significantly predicted poor MH, EB and sleep quality. Furthermore, such a perception had a moderating effect on the association between certain personality traits and MH as well as LB. Notably, significant interaction effects were found among NPC, agreeableness, and MH, as well as among NPC, extraversion and EB. These findings shed light into the impact of perceived stress levels (as indicated by more NPC) on MH and LB, as well as the role of NPC in influencing personality, MH, and LB. The present study hopes to contribute a deeper understanding on the potential negative impacts of the pandemic, identify those at risks of poor MH and maladaptive behaviours, as well as shape future health recommendations.Bachelor of Arts in Psycholog
HDM extract prevents LPS-induced expression of Th1-immune response factors in MH-S cells through a TLR2 dependent mechanism.
No full text<p>(A) Inhibition of the LPS-stimulated induced MH-S cells IL-12 production by the TLR2 agonists (see legend figure 5 for experimental details; statistical analysis was performed using Student’s <i>t</i>-test; ** p<0.01; *** p<0.005). (B) HDM extract inhibition of LPS-induced T-bet expression in MH-S cells. MH-S cells were treated as above except that T-bet expression was evaluated by RT-PCR amplification at 2h and 6h post LPS addition. (C) Suppression by TLR2 antibodies of the inhibitory effect of the TLR2 ligands on the LPS induced T-bet expression (TLR ligands are used at the higher inhibitory concentration tested in B).</p
Fabrication and structural analysis of binary colloidal crystals with two-dimensional superlattices
No full textBinary colloidal crystals (see Figure) have been fabricated via the confined convective assembly method. By adjusting the ratio of the diameters of the small and large particles and the concentration of the small particles, various superlattices, including the previously reported LS2 and LS3 structures along with the new LS4 and LS5 structures, have been prepared
Direction of effects for combinations of DVA, MH, and SU outcomes at post-intervention.
No full textHarvest plots A, B, and C: Bars represent studies; Placement of bars represents direction of effect for DVA, MH, and/or SU outcomes; Numbers above bars represent number of outcome measures the categorisation is based on displayed in the following order where applicable: DVA, MH, SU; Number in bars represent the study number; Colour represents whether any of the SMDs 95% confidence intervals are positive, cross 0, or are negative (see key). Harvest plot D is same as previous but with the following addition: Height of the bar represents direction of effect for SU.</p
Direction of effects for combinations of DVA, MH, and SU outcomes at follow-up.
No full textHarvest plots A, B, and C: Bars represent studies; Placement of bars represents direction of effect for DVA, MH, and/or SU outcomes; Numbers above bars represent number of outcome measures the categorisation is based on displayed in the following order where applicable: DVA, MH, SU; Number in bars represent the study number; Colour represents whether any of the SMDs 95% confidence intervals are positive, cross 0, or are negative (see key). Harvest plot D is same as previous but with the following addition: Height of the bar represents direction of effect for SU.</p
Brittle failure in polycrystalline RVEs by a grain-scale cohesive boundary element formulation
No full textPolycrystalline materials are commonly employed in engineering structures. For modern applica-
tions a deep understanding of materials degradation is of crucial relevance. It is nowadays widely
recognized that the macroscopic material properties depend on the microstructure.
The polycrystalline microstructure is characterized by the features of the grains and by the phys-
ical and chemical properties of the intergranular interfaces, that have a direct influence on the
evolution of the microstructural damage. The experimental investigation of failure mechanisms in
3D polycrystals still remains a challenging task.
A viable alternative, or complement, to the experiments is Computational Micromechanics. The
present-day availability of cheaper computational power is favoring the advancement of the sub-
ject. A popular approach for polycrystalline fracture problems consists in the use of cohesive sur-
faces embedded in a Finite Element (FE) representation of the microstructure, so that the evolution
of microcracks stems as an outcome of the simulation, without any assumptions, see e.g. [4].
An alternative to the FEM is the Boundary Element Method (BEM). A 2D cohesive BE formula-
tion for intergranular failure and a 3D BE formulation for polycrystalline materials homogeniza-
tion have been recently proposed [1–3].
In this work, a novel 3D grain-level model for the study of polycrystalline intergranular degra-
dation and failure is presented. The microstructures are generated as Voronoi tessellations, that
mimic the main statistics of polycrystals. The formulation is based on a grain-boundary integral
representation of the elastic problem for the crystals, seen as anisotropic domains with random
crystallographic orientation in space. The integrity of the aggregate is restored by enforcing suit-
able intergranular conditions. The evolution of intergranular damage is modeled using an extrinsic
irreversible mixed-mode cohesive linear law. Upon interface failure, non-linear frictional con-
tact analysis is used, to address separation, sliding or sticking between micro-crack surfaces. An
incremental-iterative algorithm is used for tracking the micro-cracking evolution. Several numeri-
cal tests have been performed and they demonstrated the capability of the formulation to track 3D
micro-cracking, under either tensile or compressive loads
The times; or, the age of ruin. A poem. [electronic resource] : By the author of "A poetical and complimentary epistle to R. Brothers the prophet, and N. B. Halhed, Esq;" &c.
No full textPublication date from MH-H.Electronic reproduction.English Short Title Catalog,Reproduction of original from Harvard University Houghton Library
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