107 research outputs found
Analyse comparative de l'informatisation. Proposition pour un indicateur combiné
No full textDrawing upon a study of German firms, the author proposes the formulation of a combined indicator for measuring the degree of informatization and telecommunication of a firm. This indicator comprises the static component (facilities or the stock of equipment), the dynamic component (related to investments), the intensity of use, and the " information occupation " represented by the number of employees with IT qualifications. The author also argues in favour of the incorporation of qualitative parameters.En partant d'une étude sur les entreprises allemandes, l'auteur propose l'élaboration d'un indicateur combiné permettant de mesurer le degré d'informatisation et de télécommunication. Les principales composantes de cet indicateur sont le statique (l'équipement ou le stock de matériels), le dynamique (lié à l'investissement), l'intensité d'utilisation et le « professionnalisme informatique » représentant le nombre de personnes qui possèdent dans l'entreprise des compétences informatiques et/ou télécommunicationnelles. L'auteur appelle in fine à une intégration de paramètres qualitatifs.Preissl Brigitte. Analyse comparative de l'informatisation. Proposition pour un indicateur combiné. In: Réseaux, volume 16, n°87, 1998. Les claviers. pp. 119-134
THE GERMAN SERVICE GAP OR: RE-ORGANISING THE MANUFACTURING--SERVICES PUZZLE
No full textTwo phenomena make the distinction between services and manufacturing obsolete: the tertiarization of manufacturing and the introduction of information technologies in service industries. Competitiveness of manufacturing firms increasingly depends on the quality of service inputs and on packages of goods and services. Information and communication technologies introduce 'industrial' processes of production in service industries. Hence, it does not make sense any more to use categories such as 'services' or 'manufacturing'. Instead, it would be more meaningful to group economic activities according to input configurations. This paper will discuss these issues in the context of the supposed German 'service gap'. Copyright � 2007 The Author; Journal compilation � 2007 Blackwell Publishing Ltd.
Sequencing open chromatin of single cell nuclei: snATAC-seq v1
No full textProtocol for applying the TN5-based ATAC-seq method to the analysisof the chromatin of single cell nuclei isolated from brain tissue, as performed withinthe Center for Epigenomics of the Mouse Bain Atlas (CEMBA) and in coordination with the BRAIN Initiative Cell Census Network (BICCN). </p
Author Correction: Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation
No full textAnalysis of chromatin accessibility can reveal transcriptional regulatory sequences, but heterogeneity of primary tissues poses a significant challenge in mapping the precise chromatin landscape in specific cell types. Here we report single-nucleus ATAC-seq, a combinatorial barcoding-assisted single-cell assay for transposase-accessible chromatin that is optimized for use on flash-frozen primary tissue samples. We apply this technique to the mouse forebrain through eight developmental stages. Through analysis of more than 15,000 nuclei, we identify 20 distinct cell populations corresponding to major neuronal and non-neuronal cell types. We further define cell-type-specific transcriptional regulatory sequences, infer potential master transcriptional regulators and delineate developmental changes in forebrain cellular composition. Our results provide insight into the molecular and cellular dynamics that underlie forebrain development in the mouse and establish technical and analytical frameworks that are broadly applicable to other heterogeneous tissues
Author Correction: Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation
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