45 research outputs found
sj-tif-2-tam-10.1177_17588359221134065 – Supplemental material for Improved overall survival of metastatic renal cell carcinoma patients in the era of modern tyrosine kinase inhibitors and immune checkpoint inhibitors: results from a real-life, population-based Austrian study comprising three decades of follow-up
No full textSupplemental material, sj-tif-2-tam-10.1177_17588359221134065 for Improved overall survival of metastatic renal cell carcinoma patients in the era of modern tyrosine kinase inhibitors and immune checkpoint inhibitors: results from a real-life, population-based Austrian study comprising three decades of follow-up by Hannah Fluhrer, Georg C. Hutterer, Sylvia Golbeck, Michael Stidl, Tobias Niedrist, Renate Pichler, Johannes Mischinger, Maximilian Seles, Sebastian Mannweiler, Jasmin Spiegelberg, Thomas Bauernhofer, Philipp J. Jost, Sascha Ahyai, Richard Zigeuner, Martin Pichler and Dominik A. Barth in Therapeutic Advances in Medical Oncology</p
sj-tif-1-tam-10.1177_17588359221134065 – Supplemental material for Improved overall survival of metastatic renal cell carcinoma patients in the era of modern tyrosine kinase inhibitors and immune checkpoint inhibitors: results from a real-life, population-based Austrian study comprising three decades of follow-up
No full textSupplemental material, sj-tif-1-tam-10.1177_17588359221134065 for Improved overall survival of metastatic renal cell carcinoma patients in the era of modern tyrosine kinase inhibitors and immune checkpoint inhibitors: results from a real-life, population-based Austrian study comprising three decades of follow-up by Hannah Fluhrer, Georg C. Hutterer, Sylvia Golbeck, Michael Stidl, Tobias Niedrist, Renate Pichler, Johannes Mischinger, Maximilian Seles, Sebastian Mannweiler, Jasmin Spiegelberg, Thomas Bauernhofer, Philipp J. Jost, Sascha Ahyai, Richard Zigeuner, Martin Pichler and Dominik A. Barth in Therapeutic Advances in Medical Oncology</p
Cold cracking in DC-cast high strength aluminum alloy ingots: An intrinsic problem intensified by casting process parameters
No full textFor almost half a century the catastrophic failure of direct chill (DC) cast high strength aluminum alloys has been challenging the production of sound ingots. To overcome this problem, a criterion is required that can assist the researchers in predicting the critical conditions which facilitate the catastrophic failure of the ingots. This could be achieved at first glance by application of computer simulations to assess the level and distribution of residual thermal stresses. However, the simulation results are only able to show the critical locations and conditions where and when high stresses may appear in the ingots. The prediction of critical void/crack size requires simultaneous application of fracture mechanics. In this paper, we present the thermo-mechanical simulation results that indicate the critical crack size distribution in several DC-cast billets cast at various casting conditions. The simulation results were validated upon experimental DC-casting trials and revealed that the existence of voids/cracks with a considerable size is required for cold cracking to occur.Materials Science & EngineeringMechanical, Maritime and Materials Engineerin
Context-Enabled Optimization of Energy-Autarkic Networks for Carrier-Grade Wireless Backhauling
No full textThis work establishes the novel category of coordinated Wireless Backhaul Networks (WBNs) for energy-autarkic point-to-point radio backhauling. The networking concept is based on three major building blocks: cost-efficient radio transceiver hardware, a self-organizing network operations framework, and power supply from renewable energy sources. The aim of this novel backhauling approach is to combine carrier-grade network performance with reduced maintenance effort as well as independent and self-sufficient power supply. In order to facilitate the success prospects of this concept, the thesis comprises the following major contributions: Formal, multi-domain system model and evaluation methodology
First, adapted from the theory of cyber-physical systems, the author devises a multi-domain evaluation methodology and a system-level simulation framework for energy-autarkic coordinated WBNs, including a novel balanced scorecard concept. Second, the thesis specifically addresses the topic of Topology Control (TC) in point-to-point radio networks and how it can be exploited for network management purposes. Given a set of network nodes equipped with multiple radio transceivers and known locations, TC continuously optimizes the setup and configuration of radio links between network nodes, thus supporting initial network deployment, network operation, as well as topology re-configuration. In particular, the author shows that TC in WBNs belongs to the class of NP-hard quadratic assignment problems and that it has significant impact in operational practice, e.g., on routing efficiency, network redundancy levels, service reliability, and energy consumption. Two novel algorithms focusing on maximizing edge connectivity of network graphs are developed.
Finally, this work carries out an analytical benchmarking and a numerical performance analysis of the introduced concepts and algorithms. The author analytically derives minimum performance levels of the the developed TC algorithms. For the analyzed scenarios of remote Alpine communities and rural Tanzania, the evaluation shows that the algorithms improve energy efficiency and more evenly balance energy consumption across backhaul nodes, thus significantly increasing the number of available backhaul nodes compared to state-of-the-art TC algorithms
Translation and the early scientific press: Or: Why scientific papers should be regarded as translatorial activities
No full textWhile the first discipline-specific scientific periodicals of the late 18th century are marked by the integration of full-text translations, these translations nearly disappeared from scientific periodicals towards the end of the 19th century. This development can be seen in the light of tensions already present in the early practice of full-text translations, such as the preference for ‘original’ material expressed by the readership of the journals, the time lag produced by translations, the changing role of national public spheres, as well as tensions related to the medium of the periodical press. However, the near disappearance of full-text translations could also be seen as a transformation of translatorial activity within the scientific community. With the evolution of the scientific paper as having to state the current state of research for a given topic on an ideally transnational level, the translatorial activity is transferred to every author of a scientific paper – an evolution that goes hand in hand with the idea of scientific papers as addressing a ‘universal’ audience, despite their being written in a particular natural language
The flow cytometric DNA index can predict the presence of lymph node metastases in invasive ductal breast carcinoma
No full textMarked foreign body reaction and thrombus formation after transcatheter closure of a patent foramen ovale
No full text
Variational method for motion corrected reconstruction with MRI information in positron emission tomography
No full textLim1, an embryonal transcription factor, is absent in multicystic renal dysplasia, but reactivated in nephroblastomas
No full textOBJECTIVE: Lim1 (Lim homeobox 1) plays an important role during rodent renal development; however, its rolein human kidney development and disease is still unclear. METHODS: We investigated LIM1 expression during human renal development, in dysplastic kidneys and in renal neoplasms using immunohistochemistry. RNA levels in renal carcinomas were determined by quantitative RT-PCR, and the potential roles of LIM1 in mesenchymal-epithelial transition and cell cycle were investigated in a cell culture model. RESULTS: LIM1 was detected in pretubular aggregates, S-shaped and comma-shaped bodies as well as immature glomeruli between 10 and 30 weeks of gestation. Eleven dysplastic kidneys showed no expression of LIM1. In contrast, 12 of 32 nephroblastomas showed nuclear positivity. One regressive nephroblastoma had diffuse expression of LIM1 in tubular structures, all others showed focal positivity in mesenchymal, blastemal and epithelial structures. Renal cell carcinomas revealed no expression of LIM1. Overexpression of LIM1 in a cell culture model led to an increase in KERATIN7 expression but no change in the cell cycle. CONCLUSION: Our study supports the concept of a causative role of LIM1 deficiency in the development of multicystic kidney. In a small subset of nephroblastomas with a more diffuse expression pattern LIM1 might also contribute to the pathogenesis of these lesions
