235 research outputs found
The importance of high-quality ‘big data’ in the application of artificial intelligence in inflammatory bowel disease
No full textQuality of Care in Ulcerative Colitis: A Modified Delphi Panel Approach
No full textObjectives: To establish clinical consensus on important and relevant quality-of-care (QoC) attributes in ulcerative colitis (UC) treatment that may improve treatment outcomes and guide best practices. Methods: Thirty-eight QoC attributes were identified in a literature review. Sixteen European-based experts were selected based on their contributions to UC guidelines, publications, and patient care. A 3-round, modified Delphi panel was conducted including an interview round, and 2 web-based rounds to reach consensus and finalize a QoC attribute list. Results: The draft QoC attribute list derived from a literature review and Round 1, expert interviews, comprised 63 attributes. In Rounds 2 and 3, the QoC attributes frequently rated as critically important were diagnosis (n = 15, 93.8%), treatment adherence (n = 15, 93.8%), and access to care/treatment (Round 2: n = 14, 87.5%; Round 3: n = 15, 93.8%). The final QoC attribute list consisted of 61 attributes across 20 domains, with the most attributes reported in the "treatment goals" domain (n = 9). Conclusion: QoC is a complex and evolving concept that can improve outcomes while maximizing healthcare resources. Limited time and resources hamper clinicians' ability to openly and empathetically communicate with patients; novel technology may help to offer solutions
Letter: should we intensify infliximab in acute severe ulcerative colitis? Author's reply
No full textECCO Topical Review: Roadmap to optimal peri-operative care in IBD.
No full textBACKGROUND AND AIMS
Despite the advances in medical therapies, a significant proportion of patients with inflammatory bowel diseases (IBD) require surgical intervention. This Topical Review aims to offer expert consensus practice recommendations for peri-operative care to optimise outcomes of IBD patients who undergo surgery.
METHODS
A multidisciplinary panel of IBD health care providers systematically reviewed aspects relevant to peri-operative care in IBD. Consensus statements were developed using Delphi methodology.
RESULTS
A total of 20 current practice positions were developed following systematic review of the current literature covering use of medication in the peri-operative period, nutritional assessment and intervention, physical and psychological rehabilitation and prehabilitation and immediate postoperative care.
CONCLUSION
Peri-operative planning and optimization of the patient are imperative to ensure favourable outcomes and reduced morbidity. This Topical Review provides practice recommendations applicable in the peri-operative period in IBD patients undergoing surgery
Exploration of Non-MPB PZT Compositions for High Piezoelectric Voltage Sensitive 0-3 Composites
No full textPiezoelectric composites provide an opportunity to make robust piezoelectric sensors. These materials are based on piezoelectric ceramic powders or particles, which are dispersed in a polymer matrix. In most cases, piezoelectric composites use the same ceramic compositions as the ones used in piezoelectric ceramics. These compositions consist of lead zirconium titanate (PZT) with a composition close to the morphotropic phase boundary (MPB). This research work focuses on exploring the performance of non-MPB compositions of PZT ceramic particles in order to obtain high voltage sensitive 0-3 PZT-Epoxy composites. The PZT ceramic compositions (PbNb0.01[ZrxTi(1-x)]O3), ranging from pure tetragonal lead titanate (x=0) to rhombohedral (x=0.80) were prepared using the mixed oxide method. These ceramic particles were characterized using XRD, SEM and particle size analyser and were used to prepare both sintered ceramics and 0-3 PZT-epoxy composites. The effect of the ceramic filler composition on the dielectric and piezoelectric properties of the PZT-Epoxy composites was investigated. Unlike PZT ceramics, the best piezoelectric properties were not observed in the MPB-based composites but in the pure tetragonal phase. It was observed that the dielectric constant of the ceramic particles had minimal influence on the effective dielectric constant (?r) and the piezoelectric charge constant (d33) of the piezoelectric composite due to the depolarization effect of the high dielectric filler materials. The experimentally determined values of the dielectric and piezoelectric properties of the piezoelectric composites were validated using analytical models. The influence of electric fatigue on the polarization of the PbTiO3 (PT) and morphotropic phase boundary (MPB) based composites were also examined. Finally, a material selection criterion was proposed in order to develop piezoelectric composites with high voltage sensitivity. This general material selection criterion is not limited to PZT based ceramics but is also applicable to lead-free ceramic filler materials. Thus, the current research work paves the way for the development of environmental friendly lead-free piezoelectric composites devices with enhanced sensory properties.Novel Aerospace Materials (NovAM)Mechanics, Aerospace Structures & MaterialsAerospace Engineerin
Numerical Analysis on a Double Pipe Heat Exchanger with Twisted Tape Induced Swirl Flow on Both Sides
No full textAbstractTwisted tape inserts are widely used for enhancing heat transfer in heat exchangers. They enhance heat transfer by inducing swirl flow in the flow channel, thereby enabling good mixing within the fluid and by increasing the effective flow length of the flow channel. They also increase pressure drop but their overall performance is found to be advantageous in many cases. In this work, an attempt is made to analyse the performance of a modified double pipe heat exchanger with twisted tape induced swirl flow on both sides. The numerical analysis were done in turbulent flow conditions with twisted tape inserts of twist ratio 5 and 3. The results obtained are validated using established correlations available in the literature. The fin effect of twisted tape is also discussed
Letter: infliximab induction regimens in steroid‐refractory acute severe colitis—a propensity score analysis. Authors' reply
No full textPractical guidance for the management of inflammatory bowel disease in patients with cancer. Which treatment?
No full textClinicians involved in the treatment of inflammatory bowel disease (IBD) increasingly come across patients with current or previous history of malignancies. With increasing and earlier use of immunosuppression and biologics in IBD patients, the question arises whether these treatments further increase the risk of new or recurrent cancers. A number of population-based observational studies have now reported the odds of development of new or recurrent cancers with thiopurines and antitumour necrosis factors (anti-TNFs). These data combined with data arising from treatment registries from other immune disorders such as rheumatoid arthritis are providing evidence of relative risks and safety profiles of these agents in the setting of active or prior cancer. Data from transplant literature give an indication for providing a drug-holiday period in patients with treated cancers. The risks of the treatment should be considered alongside the risk associated with withholding these effective treatments in patients with active IBD. In this review, we aim to summarize the current evidence in this area and provide a practical guidance
Enzyme liquefaction and development of novel value added products from Wood apple (Feronia elephantum)- an untapped forest resource
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
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