179 research outputs found
Supplemental Material - Behavioral Impairments and Increased Risk of Cortical Atrophy Risk Scores Among World Trade Center Responders
No full textSupplemental Material for Behavioral Impairments and Increased Risk of Cortical Atrophy Risk Scores Among World Trade Center Responders by Allen P. F. Chen, Zahinoor Ismail, Frank D. Mann, Evelyn J. Bromet, Sean A. P. Clouston, and Benjamin J. Luft in Journal of Geriatric Psychiatry and Neurology</p
CSS877651 Supplemental Material - Supplemental material for Association of Severity of Posttraumatic Stress Disorder With Inflammation: Using Total White Blood Cell Count as a Marker
No full textSupplemental material, CSS877651 Supplemental Material for Association of Severity of Posttraumatic Stress Disorder With Inflammation: Using Total White Blood Cell Count as a Marker by Farrukh M. Koraishy, Joanne Salas, Thomas C. Neylan, Beth E. Cohen, Paula P. Schnurr, Sean Clouston and Jeffrey F. Scherrer in Chronic Stress</p
sj-docx-1-cpx-10.1177_21677026221132552 – Supplemental material for The Role of Personality in the Mental and Physical Health of World Trade Center Responders: Self-Reports Versus Informant-Reports
No full textSupplemental material, sj-docx-1-cpx-10.1177_21677026221132552 for The Role of Personality in the Mental and Physical Health of World Trade Center Responders: Self-Reports Versus Informant-Reports by Joshua R. Oltmanns, Camilo Ruggero, Jiaju Miao, Monika Waszczuk, Yuanyuan Yang, Sean A. P. Clouston, Evelyn J. Bromet, Benjamin J. Luft and Roman Kotov in Clinical Psychological Science</p
The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness
No full textBook reviewBy Gilberto Levy and Bruce Levin. ISBN 978-1-118-64585-7, John Wiley & Sons, Inc. Hoboken, NJ 2014</jats:p
GJB6, of which mutations underlie Clouston syndrome, is a potential direct target gene of p63
No full textBackground: Clouston syndrome is a rare autosomal dominant condition characterized by hypotrichosis, nail dystrophy, and occasionally palmoplantar keratoderma. The disease is caused by mutations in GJB6 gene, which encodes a gap junction protein connexin 30 (Cx30). Objective: To disclose the molecular basis of Clouston syndrome in a Lebanese-German family, and also to determine precise expression of Cx30 in normal skin of humans and mice, as well as transcriptional regulation for the GJB6 expression. Methods: We searched for mutations in the GJB6 gene using DNA of the family members with Clouston syndrome. We performed immunostaining to localize the Cx30 expression in normal human skin and mouse embryos. In addition, we did a series of in vitro studies to investigate if the GJB6 could be a direct transcriptional target gene of p63. Results: We identified a recurrent heterozygous mutation c.31GC (p.Gly11Arg) in the GJB6 gene in the Lebanese-German family with Clouston syndrome. Immunostaining in normal human skin sections demonstrated predominant expression of Cx30 in hair follicles, nails, and palmoplantar epidermis, which partially overlapped with p63 expression. We also showed co-expression of Cx30 and p63 in developing mouse hair follicles and nail units. In cultured cells, the GJB6 expression was significantly upregulated by ΔNp63α isoform. Further in vitro analyses suggested that ΔNp63α was potentially involved in the GJB6 expression via binding to the sequences in intron 1 of the GJB6 gene. Conclusion: Our data further underscore the crucial roles of Cx30 in morphogenesis and development of skin and its appendages. © 2012 Japanese Society for Investigative Dermatology.Baris H, 2008, BRIT J DERMATOL, V159, P1373, DOI 10.1111-j.1365-2133.2008.08796.x; Birkaya B, 2007, BMC MOL BIOL, V8, DOI 10.1186-1471-2199-8-43; Celli J, 1999, CELL, V99, P143, DOI 10.1016-S0092-8674(00)81646-3; Chen N, 2010, J DERMATOL, V37, P559, DOI 10.1111-j.1346-8138.2009.00768.x; Clouston HR, 1929, CAN MED ASSOC J, V21, P18; COTSARELIS G, 1990, CELL, V61, P1329, DOI 10.1016-0092-8674(90)90696-C; Dahl E, 1996, J BIOL CHEM, V271, P17903; Essenfelder GM, 2004, HUM MOL GENET, V13, P1703, DOI 10.1093-hmg-ddh191; Essenfelder GM, 2005, GENE, V350, P33, DOI 10.1016-j.gene.2004.12.048; Koster MI, 2007, CELL CYCLE, V6, P269, DOI 10.4161-cc.6.3.3792; Lamartine J, 2000, NAT GENET, V26, P142; Langlois S, 2007, J BIOL CHEM, V282, P30171, DOI 10.1074-jbc.M703623200; LEWIN K, 1965, BRIT J DERMATOL, V77, P421, DOI 10.1111-j.1365-2133.1965.tb14672.x; Marinari B, 2009, J INVEST DERMATOL, V129, P60, DOI 10.1038-jid.2008.202; McGrath JA, 2001, HUM MOL GENET, V10, P221, DOI 10.1093-hmg-10.3.221; Mikkola ML, 2007, CELL CYCLE, V6, P285, DOI 10.4161-cc.6.3.3798; NIWA H, 1991, GENE, V108, P193; Noguchi K, 2003, J BIOL CHEM, V278, P25600, DOI 10.1074-jbc.M302648200; Ohyama M, 2006, J CLIN INVEST, V116, P249, DOI 10.1172-JCI26043; Osada M, 2005, MOL CELL BIOL, V25, P6077, DOI 10.1128-MCB.25.14.6077-6089.2005; Oshima H, 2001, CELL, V104, P233, DOI 10.1016-S0092-8674(01)00208-2; Perrin C, 2004, BRIT J DERMATOL, V151, P362, DOI 10.1111-j.1365-2133.2004.06108.x; Saito K, 2006, J UROLOGY, V176, P2268, DOI 10.1016-j.juro.2006.07.057; Scott CA, 2011, BIOCHEM J, V438, P245, DOI 10.1042-BJ20110278; Shimada A, 1999, CANCER RES, V59, P2781; Shimomura Y, 2008, DEVELOPMENT, V135, P743, DOI 10.1242-dev.006718; Shimomura Y, 2010, NATURE, V464, P1043, DOI 10.1038-nature08875; Smith FJD, 2002, J INVEST DERMATOL, V118, P530, DOI 10.1046-j.0022-202x.2001.01689.x; Vigano MA, 2006, EMBO J, V25, P5105, DOI 10.1038-sj.emboj.7601375; Winter H, 1997, J BIOL CHEM, V272, P32345, DOI 10.1074-jbc.272.51.32345; Yang AN, 1998, MOL CELL, V2, P305, DOI 10.1016-S1097-2765(00)80275-011
Partnered for health: How health interacts with partnership and how policy manages health inequality
No full textMarriage may benefit individuals as much as smoking harms their health. Men, in particular benefit from a gain of as much as 10 years in life expectancy; for women the gain is 4 years. While we know that these inequalities exist between those who are single and those who live in partnerships (marital or cohabitating), we do not know why they exist. Here are four hypotheses that suggest why there may be a relationship: Partnership Benefits, Positive Selection, Cleaning Up, and Negative Selection. However, the impact of each is related to policy context and gender over the life course. This dissertation uses longitudinal data from panel studies in Canada and the U.S. in order to consider the variable impact of gender and policy in changing the incentives involved in partnering and partnership type. We focus on the transition into partnership as a highly selective event that is followed, in theory, by a period of health and social benefits. We use smoothed non-linear adjusted health curves surrounding the transition into partnership in order to determine who partners, along with when and how much benefits accrue. All analyses are separated by gender to understand the role that gender has in finding partners and benefiting from partnerships. Findings suggest first partnership benefits dominate in Canada, and positive selection dominates in the U.S., that differences in social benefits and healthcare policy determine the importance of health selection. We also show that partnership type plays a role that depends on policy regime and that gender modifies the role that benefits and selection play. This dissertation therefore highlights the unintended impact that social policies have in determining who partners and when. Put simply, 'marriage matters' only when being 'not married' (i.e. single or cohabiting) is risky.Le mariage peut être avantageux pour les gens, tout autant que le tabagisme nuit à leur santé. Les hommes, en particulier, bénéficient d'une augmentation de dix ans de leur espérance de vie; pour les femmes, cette augmentation est de quatre ans. Bien que nous soyons conscients que ces inégalités existent entre les personnes célibataires et celles qui vivent en partenariat (mariage ou concubinage), il existe quatre hypothèses qui semblent indiquer en partie ce qui se passe et pourquoi il en est ainsi : les avantages du partenariat, la sélection positive, la responsabilisation et la sélection négative. Cependant, l'incidence de chacune est liée au sexe des personnes et au contexte politique au cours de leur vie. La présente dissertation s'appuie sur des données longitudinales provenant d'études par panel réalisées au Canada et aux États-Unis, afin d'examiner l'incidence variable du sexe et des politiques dans la modification des incitations en cause dans les partenariats et les types de partenariats. Nous nous concentrons sur la transition vers le partenariat comme un événement hautement sélectif qui est suivi, en théorie, par une période d'avantages sur les plans social et de la santé. Nous utilisons des courbes de santé non linéaires ajustées lissées pour illustrer la transition vers un partenariat en vue de déterminer les personnes qui entrent en partenariat, le moment qu'elles choisissent pour le faire, ainsi que les avantages que ce partenariat leur procure. Toutes les analyses sont séparées par sexe pour comprendre le rôle variable que le sexe exerce sur la découverte d'un partenaire et les avantages que procure le partenariat. Les résultats semblent indiquer que les politiques publiques, surtout celles touchant les soins de santé, déterminent l'importance de la sélection relative à la santé, et que le sexe modifie le rôle que jouent les avantages et la sélection. La présente dissertation met donc en évidence les effets non intentionnels que les politiques sociales produisent dans la détermination des personnes qui entrent en partenariat et du moment qu'elles choisissent pour le faire. En d'autres termes, le « mariage est important » seulement lorsque le fait de n'être « pas marié » (c.-à-d., célibataire ou en concubinage) est risqué
Income, health, and health insurance: Longitudinal health selection in logged income by health insurance status in Canada. Conference for New Researchers, McGill University, february 2007
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