1,721,307 research outputs found
Oral lichen planus: clinical and histological evaluation in an open trial using a low molecular weight heparinoid (sulodexide)
No full textBurning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy
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Release Rates for [t] in VCV Sequences Estimated from Aerodynamic Data
No full textAccording to Stevens, "quantitative data must be obtained on rates of release and closure of articulators". Here, we use aerodynamic data in an orifice equation to estimate the rate of increase in the cross-sectional constriction area for [t] in different vowel contexts for 10 English speakers. Analyses of the results indicate that in most cases, the rate of release of [t] is significantly faster when an open vowel follows than when a close vowel follows
Association between different alcoholic beverages and leukoplakia among non- to moderate-drinking adults: A matched case-control study
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An articulatory-acoustic-aerodynamic analysis of [s] in VCV sequences
No full textPrevious studies of the effect of vowel context on fricatives show seeming contradictions in the case of /s/: acoustic analysis shows the greatest context effect, while aerodynamic analysis shows relatively little effect, for the same subject. In this study, aerodynamic, acoustic, and articulatory data for the same subject producing /s, z/ in a variety of contexts were compared systematically. The strong acoustic effect of the /u - u/ context exists with /z/ as well as /s/, and appears to arise from a whistle-like source mechanism caused by lip rounding; the main tongue constriction does not appear to be immune to vowel context. Our interpretation of aerodynamic data as constrictions in series can be generalized to include the influence of lip rounding, thus: for this speaker and for these speaker-like sequences, the area of the vocal tract constriction for /s/ is independent of the vowel context but the overall aerodynamic effect does vary with lip rounding. Our aerodynamic and acoustic data seem to be consistent; both support the view that some rounding extends into the /s/ fricative
Oral mucosal disease: pemphigus
No full textPemphigus defines a group of rare mucocutaneous autoimmune diseases of which pemphigus vulgaris (PV) is the most common. The aetiology and pathogenesis of PV are not completely clear, but there is a fairly strong genetic background: ethnic groups such as Ashkenazi Jews and people of Mediterranean and Indian origin are particularly susceptible and there is a link to HLA class II alleles. The initiating event in PV is not clear, but circulating IgG autoantibodies develop, directed particularly against the intercellular cadherin desmoglein 3 (Dsg3) in desmosomes of stratified squamous epithelium. Oral lesions often herald the disease and are initially vesiculobullous, but they rupture readily to leave ulcers. Involvement of other mucosa and skin is almost inevitable and PV is potentially life threatening. The diagnosis is confirmed by biopsy with histological examination and immunostaining. Management is largely by systemic immunosuppression with corticosteroids, usually azathioprine or other agents, but newer treatments with potentially fewer adverse effects look promisin
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