733 research outputs found
Bruno Alfieri, “The United States at the 24th Biennale”; Introduction to Carla Lonzi, “An Operative Category”; Introduction to Mario Diacono, “Matter-Destructure: Richard Serra, Bruce Nauan, Joseph Kosuth”; Introduction to Tommaso Trini, “Art thet is More Realistic than Reality”
No full textLa pubblicazione Hot Art, Cold War: Southern and Eastern European Writing on American Art 1945-1990, a cura di C. Hopkins, I.B. Whyte, include testi di critici di varie nazioni europee dedicati all’arte statunitense dal 1945 al 1990, che non erano mai stati tradotti in inglese, commentati da brevi introduzioni. L’autore dei testi introduttivi ai saggi ha selezionati anche i saggi.
Il testo The United States at the 24th Biennale (Gli Stati Uniti alla XXIV Biennale) di Bruno Alfieri pubblicato in “Arte Contemporanea”, ottobre 1948, è dedicato al Padiglione americano alla Biennale di Venezia del 1948; il testo An Operative Category (Una categoria operativa) di Carla Lonzi pubblicato in “Marcatrè”, n. 8-9-10, luglio-agosto-settembre 1964, è dedicato al new dada e alla pop art presentati alla Biennale di Venezia del 1964; il testo Matter-Destructure: Richard Serra, Bruce Nauman, Joseph Kosuth (Materia – Destruttura: Richard Serra, Bruce Nauman, Joseph Kosuth), di Mario Diacono pubblicato in “Collage, n. 9 dicembre 1970, è dedicato a tre importanti artisti americani di tendenza concettuale e processuale; il testo Art that is More Realistic than Reality” (Un’arte più realista della realtà) di Tommaso Trini pubblicato in “Corriere della Sera”, 19 settembre 1974, è una recensione della mostra tenutasi alla Rotonda della Besana e dedicata all’iperrealismo americano ed europeo.Hot Art, Cold War: Southern and Eastern European Writing on American Art 1945-1990, edited by C. Hopkins, I.B. Whyte, included text by art critics from several European Nations dedicated to the art in US since 1945 to 1990, never translated in English, analized in brief introductions. The author the introductions to the essays, has previously selected them.
The text The United States at the 24th Biennale by Bruno Alfieri, pubblished in “Arte Contemporanea”, October 1948, is dedicated to the American Pavillion at Venice Biennial 1948; the text An Operative Category by Carla Lonzi, pubblished in “Marcatrè”, no. 8-9-10, July-August-September 1964, is dedicated to new dada and to pop art, showed at Venice Biennial in 1964; the text Matter-Destructure: Richard Serra, Bruce Nauman, Joseph Kosuth by Mario Diacono, pubblished in “Collage, no. 9 dicembre 1970, is dedicated to three important American conceptual and processual artists; the text Art that is More Realistic than Reality”, by Tommaso Trini, pubblished in “Corriere della Sera”, September 19 ,1974, is a review of the exhivtion at Rotonda della Besana, Milan, dedicated to American and European hyperrealism
The clinical and non-clinical aspects of distal radioulnar joint instability after a distal radius fracture
No full textDistale radius fracturen komen veel voor. Bij ongeveer de helft van de distale radius fracturen komt een processus styloideus ulnae (PSU, distale ulna fractuur) voor. Een PSU fractuur is een indicator voor toegenomen instabiliteit. In een meta-analyse wordt geen verschil aangetoond in uitkomst van een distale radius fracturen met of zonder PSU fractuur. Hetzelfde geldt voor het al dan niet vastgroeien van het PSU. In ongeveer 33% van de distale radius fracturen komt distale radioulnaire (DRU) instabiliteit voor. Klinische testen en radiologische onderzoeken om dit te diagnosticeren zijn weinig betrouwbaar. Een CT-scan additioneel aan een r_ntgenfoto zorgt niet voor toename in overeenstemming over de uitslag. De overeenstemming tussen beoordelaars van CT-scans valt tegen, naast een grote normale spreiding. Wanneer DRU instabiliteit gediagnostiseerd is, zal de ossale anatomie genormaliseerd moeten worden. In dit proefschrift worden operatie-technieken beschreven die veilig en effectief zijn voor het oplossen van DRU instabiliteit. De auteur concludeert dat DRU instabiliteit een diagnostisch dilemma is. Onderzoek zal zich moeten richten op individuele normaalwaarden, zodat de diagnose makkelijker te stellen is. De aanbeveling wordt gedaan dat distale radius fracturen behandeld dienen te worden door gespecialiseerde teams zodat de complicaties beperkt blijven en indien nodig herkend en optimaal behandeld worden.UBL - phd migration 201
Unsolved issues in diagnostics and treatment decisions for clavicular fractures
No full textClavicular fractures are among the most common fractures of the shoulder. Displacement or comminution of the fracture fragments may lead to shortening of the clavicle, but could also cause mal-union or non-union of the clavicle and might lead to poor functional outcome. These fracture characteristics are therefore important in clinical decision making. The diagnostic aspects of clavicular fractures are evaluated in the first part of this thesis, whereas the second part describes studies on treatment and clinical outcomes. The third part of these thesis focuses on the complex biomechanics of the shoulder after a displaced midshaft clavicular fracture. The findings on diagnostic aspects underline the importance of fracture characteristics for classification and of two-view radiography for treatment decisions for clavicular fractures. Clavicular shortening after a midshaft clavicular fracture is deemed the most important factor in deciding whether or not to operate, but no clinically relevant changes after clavicular shortening in the scapular kinematics and functional outcome were demonstrated. Clavicular shortening should therefore not be used as the only reason to justify operative treatment.UBL - phd migration 201
The value of surgical treatment in abdominal emergencies : fulminant clostridium difficile colitis and severe abdominal trauma
No full textThis thesis is a combination of traumatic and non-traumatic events in the abdomen, and the optimization of treatment in both entities. The first part describes the very prevalent infection caused by the bacterium Clostridium difficile. The colitis caused by this infection can be severe and complicated, resulting in high morbidity and mortality. The studies show that by early diagnosis, improved logistics and conservative antibiotic management, treatment can be optimized. In the second part of the thesis, severe trauma to the abdomen is described. In severe renal and liver injuries, as well as in injuries to the pancreatoduodenal complex we show that a more conservative approach is possible, instead of an invasive, surgical treatment. If the clinical situation permits it, even the most severe injuries to the abdomen can be managed without an operation. Additionally we conclude that improved logistics around this specific patient population will be necessary in further optimizing outcomes.Leiden University Fund / Melvin David OlinUBL - phd migration 201
Assessment of concrete characteristics during the deliberate deformation of a flexible mould after casting
No full textExpensive CNC (computer numerical controlled)-milled formwork is required for the production of double-curved precast concrete elements for cladding or shell structures. The innovative flexible mould method for economically efficient and sustainable production of such elements, developed at Delft University of Technology, comprises the use of a flexible, CNC-controlled formwork, which is filled with self-compacting concrete (SCC). This paper describes how curved precast concrete elements can be manufactured in this open and reusable flexible mould. The proposed method reduces formwork costs of architectural freeform elements made with concrete. First, the method is described briefly, then tests are discussed, demonstrating that by measuring the rheological parameters of the concrete during the process, the right moment of deformation can be determined. The measurements show that thixotropic behaviour of concrete for this manufacturing method is very helpful, since it leads to a quick increase of the yield strength of the fresh concrete, but still leaves concrete deformable in order to prevent cracking caused by the deformation of the mould. The change of the rheological behaviour of concrete in the period between mixing and deformation of the mould was assessed; an additional study was executed in order to assess the integrity of the concrete after the deformation of the mould.Steel & Composite StructuresConcrete StructuresMaterials and Environmen
De X-factor
No full textNiet UB, maar tijdelijk ter bevordering van de PDF bestanden in het Leids Repositorium
Preservative-free IOP-lowering medications: potential advantages
No full text
I.B. Alekseev1, I.A. Koroleva2
1Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
2City Clinical Hospital No. 15, Moscow, Russian Federation
According to the World Health Organization, glaucoma is the second leading cause of blindness in the world. Pharmacotherapy for glaucoma implies long-term instillations of IOP-lowering drugs. However, more glaucoma medications per day are required with time. In these cases, fixed-dose combinations containing several active ingredients are beneficial. Potential advantages of fixed-dose combinations include reduced costs, lower risk of washout, less instillations, reduced medication regimen complexity, and saved time. This results in better treatment compliance. Reduced preservative exposure is important as well. Many studies have demonstrated that preservatives induce local adverse reactions. Elimination or minimization of adverse reactions accompanying long-term glaucoma therapy is an important resource to improve treatment compliance and, therefore, to prevent vision loss and to maintain the quality of life. Hence, glaucoma patients may benefit from the avoidance of the addit ional risk of ocular surface disorders resulting from preservative exposure.
Keywords: glaucoma, intraocular pressure, monotherapy, combined treatment, fixed-dose combinations, prostaglandin analogues, ocular surface, compliance, tafluprost, Tapticom.
For citation: Alekseev I.B., Koroleva I.A. Preservative-free IOP-lowering medications: potential advantages. Russian Journal of Clinical Ophthalmology. 2019;19(3):137–142.
About the authors:
1Igor B. Alekseev — MD, PhD, Professor, ORCID iD 0000-0002-4506-4986;
2Irina A. Koroleva — MD, PhD, ophthalmologist, ORCID iD 0000-0003-1679-5701.
1Russian Medical Academy of Continuous Professional Education. 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation.
2City Clinical Hospital No. 15. 23, Veshnyakovskaya str., Moscow, 111539, Russian Federation.
Contact information: Irina A. Koroleva, e-mail: [email protected]. Financial Disclosure: no author has a financial or property interest in any material or method mentioned. There is no conflict of interests. Received 24.06.2019.
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Treatment of unstable trochanteric fractures : the balance between man and material
No full textTreatment of unstable trochanteric fractures poses a challenge to surgeons in many ways.
Accepting this challenge requires understanding of those parameters that determine the
outcome. In operative fracture care at least four elements influence the outcome of treatment:
the patient, the fracture, the fixation device, and the surgeon. The degree of impact varies per
specific element, as does the mutual relationship.
The general physical state of the patient with a hip fracture is a parameter that is strongly
related to fracture type and outcome, but cannot or only minimally be influenced by the
surgeon: it is a relatively static parameter. The type of fracture that is sustained has similar
static characteristics: it presents as a fixed value parameter that both directly and indirectly
influences outcome, through its intrinsic stability and its tendency to redislocation. The
flXation device that will be used for osteosynthesis depends on the patient, the fracture
characteristics~ the way the fracture is classified, hospital logistics and the skills, experience
and preference of the operating surgeon. Figure 1 shows a schematic overview this mixture of
these factors with their complex and interactive connections. All these factors, separate and
combined, apply their influences upon outcome
The non-displaced scaphoid fracture : evaluation of diagnostic modalities & conservative treatment
No full text__The non-displaced scaphoid fracture: evaluation of diagnostic modalities & conservative treatment__ Over de diagnostiek en de behandeling van scafo_dfracturen bestaat nog veel verschil van mening. Een onjuiste of vertraagd ingestelde behandeling kan leiden tot ernstige complicaties. R_ntgenfoto mist een groot deel van de scafo_dfracturen. De botscintigrafie kan gebruikt worden om deze fracturen zichtbaar te maken. Een botscintigrafie is echter invasief en maakt gebruik van radioactief materiaal. Een MRI of CT zou wellicht de botscintigrafie kunnen vervangen. Dit proefschrift beschrijft twee prospectieve studies, waarbij in de eerste studie de botscintigrafie werd vergeleken met de MRI. In de tweede studie werd de botscintigrafie vergeleken met de CT. Beide onderzoeken konden niet aantonen dat de MRI en CT de botscintigrafie kan vervangen. Het probleem is dat beide onderzoeken scafo_dfracturen missen. Ook is onderzocht of een zogenaamde 'clinical prediction rule' te ontwikkelen was, om de a priori kans op een ware fractuur bij een pati_nt met de verdenking op een scafo_dfractuur te verhogen. Analyse liet zien dat er drie voorspellers significant waren: extensie < 50%, supinatiekracht < 10% en het hebben van een fractuur in de voorgeschiedenis. Tenslotte is de behandeling van scafo_dfracturen geanalyseerd. Gekeken is of een kortere behandeling mogelijk was. Normaal wordt een scafo_dfractuur 12 weken ge_mmobiliseerd met een gips. Lange immobilisatie kan klachten veroorzaken. Wij hebben onderzocht of de scafo_dfractuur ook te behandelen is middels een gipsimmobilisatie van 6 weken. Hiervoor werden 98 pati_nten geanalyseerd en na 6 weken bleek 80% te zijn genezen. Wat ook bleek is dat de localisatie met name invloed had op de functionele uitkomst van de behandeling. Om deze functionele uitkomst in beeld te brengen gebruikten we een DASH-score (Disabilities of the Arm, Shoulder and Hand score). De gemiddelde DASH-score was 6 voor 13 distale pool en 5 voor 44 middenpool fracturen. Concluderend kunnen wij stellen dat voor het opsporen van scafo_dfracturen bij pati_nten met een klinische verdenking hierop, de botscintigrafie nog steeds de gouden standaard is. Niet gedisloceerde scafo_dfracturen van de distale middenpool dienen conservatief behandeld te worden middels gipsimmobilisatie gedurende 6 weken.Traumacentrum West Nederlandse Vereniging voor Traumatologie Raad van Bestuur MCHUBL - phd migration 201
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