6,121 research outputs found
Novel insights in phosphodiesterase 4 subtype inhibition to target neuroinflammation and stimulate remyelination
No full text
Do dolphins benefit from nonlinear mathematics when processing their sonar returns?
No full textAn interview with author Tim Leighton about the paper
Opportunities for linking young surveyors across professional surveying member organisations and FIG
No full textThe Monoselective Sphingosine-1-Phosphate Receptor-1 Modulator Ponesimod Enhances Remyelination in the Cuprizone Model of Demyelination
No full textBackground: Sphingosine-1-phosphate (S1P1) receptor modulators are used clinically to treat relapsing forms of multiple sclerosis (MS). Selective functional antagonism of the S1PR1 subtype by ponesimod prevents lymphocyte egression from lymph nodes, hence hampering neuroinflammation in MS. Recent findings suggest a potential additional role for ponesimod in the Central Nervous System (CNS) in the differentiation of oligodendrocyte precursor cells (OPC) into mature myelinating oligodendrocytes, and therefore potentially having some effects on remyelination
The monoselective sphingosine-1-phosphate receptor-1 modulator ponesimod enhances remyelination in the cuprizone model of demyelination
No full textEntrepreneurial Alertness as cognitive bridge between Entrepreneurial Self-Efficacy and New Venture Creation Behaviour - Conference Presentation
No full textPonesimod, mono-selective sphingosine-1-phosphate receptor 1 modulator enhances oligodendrocyte precursor cell differentiation
No full textMS, EW ad TV report no competing interest. MAT is an employee of Janssen and may own stock or stock options in Johnson & Johnson
The Monoselective Sphingosine-1-Phosphate Receptor-1 Modulator Ponesimod Enhances Remyelination in the Cuprizone Model of Demyelination
No full textBackground: Sphingosine-1-phosphate (S1P1) receptor modulators are used clinically to treat relapsing forms of multiple sclerosis (MS). Selective functional antagonism of the S1PR1 subtype by ponesimod prevents lymphocyte egression from lymph nodes, hence hampering neuroinflammation in MS. Recent findings suggest a potential additional role for ponesimod in the Central Nervous System (CNS) in the differentiation of oligodendrocyte precursor cells (OPC) into mature myelinating oligodendrocytes, and therefore potentially having some effects on remyelination
The monoselective sphingosine-1-phosphate receptor-1 modulator ponesimod enhances remyelination in the cuprizone model of demyelination
No full text- …
