600 research outputs found
Il paziente uremico: tra dialisi e trapianto. Problematiche ed aspetti psicologici del Trapianto di organi: risultati di una ricerca.
No full textCirculating immune complexes in HBsAg carriers with chronic hepatitis and other extra-hepatic manifestations
No full textIncreasing relevance of donor-specific antibodies in antibody-mediated rejection.
No full textOne of the major concerns in organ transplantation is the early detection of humoral rejection, through improved diagnostic and prognostic biomarkers. Long-term survival of renal allografts is significantly lower in recipients developing donor-specific anti-HLA antibodies (DSAs) either pretransplant or posttransplant. Patients can form antibodies following blood transfusions, pregnancies or previous transplants. DSAs can lead to endothelial damage through complement-dependent or independent pathways. Universal testing of kidney transplant patients and careful monitoring of graft function if DSAs are detected are recommended. Since there are different techniques to detect DSAs presence and serum levels, nephrologists have to face challenges in their interpretation due to variable sensitivity and specificity. Moreover, other biomarkers of rejection (T-cell reactivity, gene expression pattern modulation, early features of immunological damage in protocol renal biopsies) may be adopted together with DSAs detection tools, thus providing a global approach to the issue. To date, however, there are no well-defined strategies of intervention in cases of humoral graft damage. Future resolution of both interpretative and therapeutic concerns will make DSAs monitoring a very effective way to predict incoming immunological events. Therefore, an operative protocol for DSAs detection in renal recipients has been illustrated
Near-Infrared Spectroscopy Measurement of Cerebro-Somatic Oxygenation Ratio (CSOR): May We Predict a Hemodynamically Significant Patent DuctusArteriosus (PDA)?
No full textBACKGROUND: Definition of hemodynamically significant PDA (HS-PDA) is still controversial and its effects on cerebral and somatic tissue oxygenation (cSO2 and sSO2) as well as on fractional oxygen extraction (FOE) are not well known.
OBJECTIVE: To use non invasive NIRS-technology in pretem infants ≤33 wks GA to evaluate differences in cSO2, postductal sSO2 and FOE according to the presence of PDA.
DESIGN/METHODS: cSO2 and thoraco-lumbar sSO2 were measured simultaneously using the INVOS oximeter (Somanetics) in clinically stable preterm babies and the mean values, over a 10-min period, were expressed as CSOR (=sSO2/cSO2). Cerebral and somatic FOE (cFOE and sFOE) were calculated according to the formula=(SaO2-regionalSO2)/SaO2. The presence and the flow pattern through PDA were assessed by echocardiography.Unpaired t-test was used.
RESULTS: 21 measurements were performed in 14 preterm infants (mean GA 29.6±3.9wks, BW 1230±460g, postnatal age 7.1±5.9 days). Mean CSOR was 1.101±0.127. No statistically significant differences were observed between babies with and without PDA for all parameters. Infants with pulsatile flow pattern at echocardiography (defined HS-PDA) showed an “inverted” CSOR<1 (mean value 0.874±0.076) mainly related to decrease in sSO2 while cSO2 was relatively spared. cFOE did not seem to be affected whereas a significant increase in sFOE was observed.[table1]
CONCLUSIONS: Our results confirm previous studies1 showing higher oxygenation of somatic compared with cerebral tissue in preterms and suggest that an “inverted” CSOR<1 might represent a sign of HS-PDA. NIRS technology could be routinely used as a trend monitor for cSO2 and sSO2 and might help in early detection of babies who would benefit from PDA closure. Due to the small sample size further studies are needed to confirm these data and adjust results for confounders. 1Petrova A PediatrCritCareMed 200
Trapidil, a PDGF-receptor antagonist, inhibits human mesangial cell (HMC) proliferation.
No full textInfluence of different dialyzer membranes on plasma fibronectin levels in hemodialyzed patients
No full textEarly withdrawal of cyclosporine improves 1-year kidney graft structure and function in Sirolimus-treated patients: Response to the authours
No full textAngiotensin converting enzyme gene polymorphism in renal transplant patients with IgA nephropathy: relationship with graft function and prevalence of hypertension.
No full textInterference of angiotensin-converting enzyme inhibitors on erythropoiesis in kidney transplant recipients: role of growth factors and cytokines
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