1,721,050 research outputs found
Storia della dermatologia a Verona
No full textQuesto libro potrebbe intitolarsi: “Storia dell’importanza dell’aspetto e della sessualità in Italia” tanto questi due punti giocano un ruolo importante in questo contesto. Durante le ricerche dell’autore, che voleva rappresentare succintamente il contributo degli Italiani nel mondo della Dermatologia e della Venereologia per fare giustizia di un vuoto immeritato e indegno, sono emerse, sempre più prepotentemente, delle storie quasi incredibili e hanno ripreso vita dei personaggi giganteschi che hanno obbligato a più di una riflessione. Quando la medicina incide sulla la vita privata, essa diventa strumento per capire i tratti caratterizzanti di una civiltà. Il fatto che la sifilide fosse chiamata dai Napoletani: “mal Francese” e dai Francesi: “mal Napolitain”, e che quasi ogni nazione chiamasse questa malattia, per spregio, con il nome della nazione confinante, la dice più lunga di molti trattati di sociologia.
I pregiudizi tuttavia non si fermano alle malattie e il semplice colore della pelle è stato storicamente usato come potente arma impropria al servizio delle più sciagurate ideologie. Alcune affermazioni, che oggi leggiamo con stupore ed ironia, sono state per troppo tempo considerate come “verità” scientifiche e, come tali, applicate nella prassi di tutti i giorni. Anche l’importanza dell’aspetto fisico (“self body image”) non è una moda di oggi come non sono una novità le pulsioni erotiche dell’essere umano. Conoscere la storia della Dermatologia e della Venereologia in Italia può essere utile a capire come eravamo e a far divenire un po’ più saggi e tolleranti i lettori di oggi
Lichen ruber planus following the administration of human anti-hepatitis B virus immunoglobulins
No full texta case of lichen ruber planus developed after the administration of anti HBV immunoglobulins is presente
The aetiology of eyelid dermatitis in a series of 191 patients
No full textSeveral studies identified allergiccontact dermatitis (ACD) as the most commoncause of periorbital dermatitis. Nevertheless,there is paucity of studies directly comparing therelevance of allergens in the eyelid dermatitis versusnon eyelid dermatitis populations.Methods. 1043 patients who presented with the clinicalsuspicion of ACD were patch tested in a 2-yearperiod. Patient demographics, clinical features, historyof atopy and results of patch tests were collected.Patch test results of patients with eyelid dermatitiswere compared with those of patients withdermatitis confined to other body areas.Results. 191 out of 1043 patch tested patients(18.3%) presented with eyelid dermatitis. Patientswith eyelid dermatitis were more likely to bewomen compared to the non-eyelid group ofpatients. The two groups did not differ as for thefrequency of atopy, including respiratory atopyand atopic dermatitis. The prevalence of ACD wasstatistically higher in the eyelid group (64.4%)compared to the non-eyelid group (49.4%). Themost relevant allergens in patients with eyelid dermatitiswere metals, preservatives and fragrances.Allergens resulting statistically more frequent ineyelid patients were methylchloroisothiazolinone/methylisothiazolinone, nickel sulphate, disperseblue 124, dimethylaminopropylamine.Conclusions. Patients with eyelid dermatitis arelikely to have ACD, and need appropriate patchtesting
Surgery and etretinate in the therapy of epidermodysplasia verruciformis [CHIRURGIA ED ETRETINATO NEL TRATTAMENTO DELL'EPIDERMODISPLASIA VERRUCIFORME]
No full textEpidermodyplasia verruciformis is a rare autosomal recessive genodermatosis characterized by disseminated chronic HPV 5,17,20 infection and by the onset of basal and prickle cell carcinomas and Bowen's disease in areas exposed to the light. Clinical case. A 49-year-old woman suffering from epidermodysplasia verruciformis and presenting numerous epitheliomas in sites exposed to light was submitted to a therapy with etretinate for 4 months. During the first month of therapy she underwent a plastic surgical treatment of the largest sized neoplasms. At the end of the pharmacological treatment, that was well tolerated by the patient, we observed a partial regression of the cancerous and precancerous lesions and a valid improvement in the skin condition. Discussion. Surgical therapy, though necessary for large-sized tumours, does not prevent the onset of new tumours and is irksome and mutilating for the patient. Etretinate proves useful in the therapy of epidermodysplasia verruciformis because it exerts an effect on the replication and differentiation of normal and neoplastic cells, stimulates the cell-mediated immune response and has a direct antiviral action. Conclusions. In the case we observed we subjected the patient to a combined pharmacological and surgical therapy. We find it difficult to distinguish between the effects of the two forms of treatment, but one year of follow-up demonstrates that a combined therapy of EV, surgical and pharmacological, is lowly mutilating for the patient but is useful in controlling the clinical picture of the disease
Skin infection due to Mycobacterium marinum in a renal transplant recipient
No full textWe report a case of a skin infection due to Mycobacterium marinum in a renal transplant recipient (RTR). The disease resolved completely after four months of treatment with ofloxacin. In RTR the clinical picture is worsened by drug-induced immunosuppression and there is a high risk of systemic involvement, impairment of renal function and rejection of the grafted kidney. The potential nephrotoxicity of some anti-tubercular drugs requires careful monitoring of renal function, so close dermatological surveillance of RTR is a prerequisite for an early diagnosis and treatment of all high-risk lesions
Etretinato ed epiderrnodisplasia verruciforrne: un caso
No full textsi presenta un caso di epidermodisplasia verruciforme trattato con etretinat
Clinical features and course of cutaneous mastocytosis in 133 children
No full textThe article reports on a clinical study on 133 children with cutaneous mastocytosis describing the clinical evolution over 10 years of follow up. The type of cutaneous mastocytosis, the clinical features, and the factors predicting long-term outcome are described
Reply to: Non-Bullous Pemphigoid: A Yet-to-Be Defined Disease Entity
No full textReply to: Non-Bullous Pemphigoid: A Yet-to-Be Defined Disease Entit
Recommended from our members
A case of nivolumab-induced bullous pemphigoid successfully treated with dupilumab
Full text linkA 76-year-old man came to our attention for the presence of itchy skin lesions localized on the trunk. The patient had a nodular melanoma removed two years earlier. Because of metastatic pulmonary melanoma, he underwent a lung lobectomy and began adjuvant therapy with nivolumab. After six months of treatment, the patient reported the appearance of itchy lesions on the trunk that were diagnosed as eczema and successfully treated with systemic corticosteroids. Upon corticosteroid discontinuation, the eruption relapsed presenting with erythematous macules, tense blisters, and erosions on the trunk and limbs. The presence of linear deposits of IgG and C3 at the dermo-epidermal junction and high serum levels of anti-BP180 antibodies confirmed the suspicion of nivolumab-induced bullous pemphigoid. Treatment with 0.6mg/kg methylprednisolone and 200mg/day doxycycline as well as nivolumab discontinuation induced temporary remission. After tapering methylprednisolone to 16mg/day, the patient developed new blisters. Therefore, dupilumab 300mg every other week was added with progressive improvement while methylprednisolone was tapered down and withdrawn after four months. After six months the patient was still in full clinical remission. Many cases of conventional bullous pemphigoid have been treated successfully with dupilumab, which can also be used safely in cancer patients without inducing overt immunosuppression
Non-Bullous Pemphigoid: A Single-Center Retrospective Study
No full textIntroduction: Bullous pemphigoid (BP) is an autoimmune disease that typically presents with blisters, but sometimes early lesions may be eczematous, maculopapular, or urticarial. The aim of the present study was to highlight possible differences between typical bullous and non-bullous pemphigoid (NBP) and compare results with the literature. Material & methods: Patients receiving a diagnosis of BP between January 2000 and December 2019 were analyzed. Patients who developed a blister after 3 months from the onset of pruritus were considered as NBP. Demographic features, clinical findings at diagnosis and at 2-year follow-up, histological features, auto-antibodies titers, comorbidities and their treatment were retrieved. Categorical variables were evaluated for normal distribution using a histogram and a Q-Q plot. The chi(2) and Fisher's exact tests were used to compare categorical variables between the groups. Continuous variables were compared between the groups using analysis of variance and the independent-samples t test. For multivariate analysis, logistic regression was performed. Results: A total of 532 patients received a diagnosis of BP. A total of 122 patients were enrolled in the study; 63 were females, and the mean age at the diagnosis was 77.2 years (+/- 11.9 SD). 98 were affected by BP and 24 were categorized as NBP. Mean time to diagnosis was 2.9 months (+/- 5.8 SD) for BP and 30.4 months (+/- 59.8 SD) for NBP (p = 0.0001). Skin manifestations in NBP patients were, in order of frequency: urticarial, papular or nodular, eczematous, and excoriations. Pruritus intensity was high but similar in the two groups (Numerical Rating Scale - NRS, 9.3 vs. 8.9). Seven out of 24 NBP patients (29%) never developed blisters; the other patients developed blisters after a mean follow-up time of 24.9 months (+/- 54.9 SD). NBP patients had a more frequent history of myocardial infarction than BP patients (37.5 vs. 10.2%; p < 0.003). More NBP patients were taking diuretics than BP patients (66.7 vs. 49%; p = 0.03). NBP patients had a worse response to pruritus compared to BP patients at 2 years (NRS 3.7 vs. 11; p 0.001). Conclusions: NBP patients have a delayed diagnosis and may be at an increased risk of cardiovascular disease, especially myocardial infarction. Severely and persistently itchy skin disorders in aged patients should be investigated for BP diagnosis
- …
