289 research outputs found
Real world biologic use and switch patterns in severe asthma : data from the International Severe Asthma Registry and the US CHRONICLE Study
No full textAcknowledgements We would like to acknowledge Dr. Ghislaine Scelo (PhD) and Dr. Nasloon Ali (PhD) of the Observational and Pragmatic Research Institute (OPRI), Singapore, for their assistance in statistical data analysis, and Ms. Audrey Ang (BSc, Hons) of the Observational and Pragmatic Research Institute (OPRI), Singapore, for editorial and formatting assistance that supported the development of this publication. Funding This study was conducted by the Observational and Pragmatic Research Institute (OPRI) Pte Ltd and was partially funded by Optimum Patient Care Global and AstraZeneca Ltd. No funding was received by the Observational & Pragmatic Research Institute Pte Ltd (OPRI) for its contribution.Peer reviewe
Déconvenues diplomatiques et philologiques de Fabricius. Les rapports de Rome avec les peuples et cités d'Italie entre 285 et 280 av. J.-C. à la lumière d'un fragment de Dion Cassius
No full textGhislaine Stouder, Fabricius' diplomatie and philological disappointment. Rome's relationship with the peoples and cities of Italy between 285 and 280 B.C., in the light of a fragment of Cassius Dio, DHA 33/1, 2007, 47-70.
Abstract: Starting from a fragment by Cassius Dio (fg. 39.1), the author takes into account an embassy disregarded by the modern historians of Roman diplomacy, that of Fabricius which the successive editors have situated in 283 B.C. The notice is reappraised in the light of the conflicts involving Rome against the Gauls, the Etruscans and the Umbrians together with the preparation for war in South Italy, in Tarentum. Thus the reexamination of the transmission and historical context of the fragment makes it possible to establish a new chronology of the event - now dated 285/4 B.C. The study also reconsiders Cassius Dio's contribution to the story of that period and enables one to appreciate his unique testimony on the outbreak of the Tarentine war.Ghislaine Stouder, Déconvenues diplomatiques et philologiques de Fabricius. Les rapports de Rome avec les peuples et cités d'Italie entre 285 et 280 av. J.-C. à la lumière d'un fragment de Dion Cassius, DHA 33/1, 2007, 47-70.
Résumé : Partant d'un fragment de Dion Cassius (fg. 39.1), l'auteur s'est attaché à l'étude d'une ambassade négligée dans l'histoire de la diplomatie romaine, celle de Fabricius que les éditeurs successifs ont datée de 283 av. J.-C. La notice est réappréciée à la lumière des conflits impliquant Rome contre les Gaulois, les Étrusques et les Ombriens, parallèlement aux préparatifs de guerre en Italie du Sud, à Tarente. Le réexamen de la transmission et du contexte historique du fragment permet ainsi d'aboutir à une chronologie nouvelle de l'épisode, désormais daté de 285/4 av. J.-C. Letude revient aussi sur l'apport pendant longtemps trop souvent négligé de Dion Cassius pour cette période de l'histoire romaine et permet d'apprécier son témoignage unique sur le déclenchement de la guerre contre Tarente.Stouder Ghislaine. Déconvenues diplomatiques et philologiques de Fabricius. Les rapports de Rome avec les peuples et cités d'Italie entre 285 et 280 av. J.-C. à la lumière d'un fragment de Dion Cassius. In: Dialogues d'histoire ancienne, vol. 33, n°1, 2007. pp. 47-70
Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry
No full textFacteurs de risque de trois cancers rares (le cancer de l'intestin grêle, le mélanome oculaire, et le carcinome nasopharyngé. Utilisation de données existantes recueillies en routine )
No full textLE KREMLIN-B.- PARIS 11-BU Méd (940432101) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF
Biometrics – do we have a choice in who has this data and how they use it?
No full textBiometrics – do we have a choice in who has this data and how they use it?
This week we dive deep into the world of biometrics, with a particular focus on facial recognition technology. What is the current state of facial recognition, and why are legal experts and privacy advocates so concerned? Additionally, we’ll explore the realm of health data; is there a necessary compromise between collecting our biometric information for improved health outcomes and safeguarding our privacy? Or can we find a way to achieve both? Joining us is Dr. Stephanie Hare, the author of Technology is Not Neutral: A Short Guide to Technology Ethics.
The programme is presented by Gareth Mitchell and the studio expert is Ghislaine Boddington.
More on this week's stories:
Dr. Stephanie Har
Abstract 1298: Genetic variants related to longer telomere length are associated with increased risk of renal cell carcinoma
No full textAbstract
Telomere length in peripheral blood leukocytes has been evaluated as a potential biomarker for renal cell carcinoma (RCC) risk in numerous observational studies, but association results have been inconsistent. These findings may have been affected by several limitations, including bias from reverse causation, reliance on a single blood specimen, residual confounding or measurement outside of the etiologically relevant time period. Germline genetic variations associated with leukocyte telomere length are not affected by an individual’s exposure to confounders and may act as unconfounded markers of the relationship between telomere length and RCC risk. We performed an analysis of genetic variants associated with leukocyte telomere length to assess the relationship between telomere length and RCC risk. Genotypes from nine telomere length associated variants were aggregated for 10,785 RCC cases and 21,579 cancer-free controls. We found that the number of telomere length variants associated with RCC risk (P-value<0.05) was significantly higher than what would be expected by chance (5/9 variants, binomial P-value=3.32×10−5). We aggregated the telomere length associated variants into a weighted genetic risk score (GRS), where one GRS unit equals to an inferred one Kb change in telomere length. Genetically inferred telomere length was associated with an increased risk of RCC (OR=2.07, 95% CI=1.70-2.52, P-value=7.14×10−13). This association was consistent across increasing deciles of telomere length GRS (Trend P-value=5.58×10−12). As a sensitivity analysis, we removed two telomere length variants in linkage disequilibrium with RCC genome-wide associated regions (rs10936599 and rs9420907) from the telomere length GRS, the association with RCC risk remained statistically significant (OR=1.73, 95% CI=1.35-2.20, P-value=1.07×10−5). When performing analyses by RCC subtype (clear cell=5,574 cases, papillary=573 cases and chromophobe=203 cases), all subtypes investigated showed positive GRS effect estimates, suggesting higher risk for longer telomeres, however, due to limited sample sizes the estimates were only significant for clear cell (OR=1.93, 95% CI=1.50-2.49, P-value=3.79×10−7) and papillary subtypes (OR=1.96, 95% CI=1.01-3.81, P-value=0.046). In conclusion, our results suggest a genetic background that favors longer telomeres is associated with increased RCC risk.
Citation Format: Mitchell J. Machiela, Jonathan N. Hofmann, Robert Carreras-Torres, Nathaniel Rothman, Paul Brennan, Mattias Johansson, Stephen J. Chanock, Kevin M. Brown, Ghislaine Scelo, Mark P. Purdue. Genetic variants related to longer telomere length are associated with increased risk of renal cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1298. doi:10.1158/1538-7445.AM2017-1298</jats:p
Fonction des dieux chez Aristophane. Exemple de Zeus, d'Hermès et de Dionysos
No full textThis article tries to show that in Aristophanes the paradoxical status of the gods - who are both revered and held up to ridicule - depends on their function in comedy. The author studies, as examples, the only three divinities that play a prominent part in Arisophanes : Zeus, Hermes and Dionysos. Represented with conventional traits, they are inserted in the ancient order that the hero rejects, but they also favour access to fiction thanks to their acts. As they simultaneously represent the ancient world and its calling into question, they therefore personify their own calling into question. This explains the double language are subjected to.Cet article essaie de montrer que le statut paradoxal réservé chez Aristophane aux dieux - qui sont à la fois révérés et tournés en dérision - tient à la fonction qui leur est assignée dans la comédie. L'auteur prend l'exemple des trois seules divinités qui jouent un rôle important dans l'œuvre d'Aristophane : Zeus, Hermès et Dionysos. Figurés sous des traits conventionnels, ils sont insérés dans l'ordre ancien que rejette le héros, mais ils favorisent également par leur action l'accès à la fiction. En représentant simultanément le monde révolu et sa remise en cause, ils personnifient donc leur propre remise en question, ce qui explique le double langage que l'on tient sur eux.Jay-Robert Ghislaine. Fonction des dieux chez Aristophane. Exemple de Zeus, d'Hermès et de Dionysos. In: Revue des Études Anciennes. Tome 104, 2002, n°1-2. pp. 11-24
Au spectacle avec Aristophane : regards échangés et métathéâtre
No full textAt the Spectacle with Aristophanes : Exchanged Looks and Metatheatre ̶ Through a precise study of the verbs ὁράω, βλέπω, θεάομαι, σκοπέω and σκέπτομαι, the author analyses how Aristophanes stages the gaze in his comedies. The action of seeing assumes a dynamic exchange between the subject and object in vision. This movement allows the character to build his identity. It also allows the development of a kind of community between characters and spectators. This conception of vision has a fundamental impact on the status of the spectator, the definition of the theatrical space and the distinction between fact and fiction.Grâce à une étude précise des verbes ὁράω, βλέπω, θεάομαι, σκοπέω et σκέπτομαι, l’auteur analyse la façon dont Aristophane met en scène le regard dans ses comédies. L’action de voir suppose un échange dynamique entre le sujet et l’objet de la vision. Ce mouvement permet au personnage de construire son identité et il permet aussi d’élaborer une sorte de communauté entre les acteurs et les spectateurs. Cette conception de la vision a des conséquences fondamentales sur le statut du spectateur, la définition de l’espace théâtral et la distinction entre la réalité et la fiction.Jay-Robert Ghislaine. Au spectacle avec Aristophane : regards échangés et métathéâtre. In: L'antiquité classique, Tome 85, 2016. pp. 19-35
Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma
No full textBiomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR)
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