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Nutritional status and Adiponectine plasma levels in patients affected by Anorexia Nervosa
Nutritional status and Adiponectine plasma
levels in patients affected by Anorexia Nervosa
C. Masoni, L. Ghiadoni, C. Scarpellini, C. Consani,
E. Matteucci & O. Giampietro
Department of Internal Medicine, University of Pisa, Italy
Background: Anorexia Nervosa (AN) is prevalent in modern
societies but is not well understood yet.
Aim: The aim of this study is to evaluate circulating levels of
Adiponectine (Apn) and the relationship between these levels
and anthropometric and metabolic parameters.
Materials and methods: The study included 40 women, 20
with AN (BMI 15Æ7 ± 2Æ1 kg m)2, age 30Æ2 ± 10Æ5 years), 12
restricter (BMI 14Æ9 ± 1Æ6 kgm)2) and 8 binge-purge subtype (BMI
18Æ3 ± 0Æ8 kg m)2), and 20 healthy controls (BMI 22Æ06 ± 0Æ93 kg
m)2, age 32Æ4 ± 4Æ4 years). Food intake was evaluated by a 5-day
24 hour dietary recall.
Results: Apn was higher (P < 0Æ001) in AN (36Æ84 ± 13Æ12 ng
mL)1) than controls (15Æ1 ± 3Æ0 ng mL)1) and (P = 0Æ004) in restricter
(41Æ8 ± 11Æ0 ng mL)1) than in binge-purge AN subtype
(22Æ1 ± 4Æ5 ng mL)1). Apn levels were negatively related with
BMI in total population (AN + C), without significance.
Total and LDL (Low Density Lipoprotein) Cholesterol levels
were higher (P < 0Æ05; P = 0Æ001) in AN (193Æ09 ± 39Æ86 mg
dL)1; 107Æ95 ± 27Æ75 mg dL)1) than C (166Æ09 ± 13Æ70 mg dL)1;
83Æ6 ± 15 mg dL)1), while Albumin was lower (P < 0Æ05) in
AN than C (4Æ40 ± 0Æ41 vs. 4Æ65 ± 0Æ57 g dL)1); no difference
between restricter and binge-purge subtype. Prealbumin and C
Somatomedine were similar in AN and C because of these
parameters rapidly change with changing of nutritional habits,
and the study’s patients were already included into nutritional
educational program: although their daily caloric intake was
lower than the recommended assumption levels of nutrients
(LARN, National Institute of Nutrition), the caloric division
between macronutrients was correct.
Conclusions: Increase of Apn in AN might be related to fat
mass reduction, in fact Apn progressively increase in losing
weight obese, or fat mass might exert negative feedback on Apn production, the severe emaciation in AN could inhibit
this feedback
CA-125 and uterine leiomyomas.
CA-125, in the past considered as marker of ovarian neoplasms, has been proven to be useful successively in several obstetric-gynecologic physiopathologic conditions (Endometriosis, beginning pregnancy, PID), united by the common characteristic of peritoneal involvement. Such evidence has suggested us to search possible correlations with uterine leiomyomatosis disease, which for its frequency has the character of a social disease. Our findings would justify the clinical use of this marker in the first screening of fibromiomas, but above all, its diagnostic utility in evolutive aspects of such pathology
Normativa e strumenti per la gestione della sicurezza in cantiere. Confronti Italia – Germania
Lo studio della normativa per la gestione della sicurezza nei cantieri in relazione alla realtà del settore delle costruzioni tedesco e italiano, con approfondimento degli strumenti operativi e analisi del dato infortunistico. Il caso di studio del cantiere per l’ampliamento del Policlinico cittadino di Brandeburgo
Between Made-in-Italy Style and Places of Global Consumption from the 1970s to the Present
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