7,117 research outputs found
Heritability and Linkage Analysis of Appendicitis Utilizing Age at Onset
No full textAppendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3. Author(s): Christopher Oldmeadow 1 * | Kerrie Mengersen 2 | Nicholas Martin 3 | David L. Duffy
Development of a cost-effectiveness model for optimisation of the screening interval in diabetic retinopathy screening
No full textBACKGROUND:
The English NHS Diabetic Eye Screening Programme was established in 2003. Eligible people are invited annually for digital retinal photography screening. Those found to have potentially sight-threatening diabetic retinopathy (STDR) are referred to surveillance clinics or to Hospital Eye Services.
OBJECTIVES:
To determine whether personalised screening intervals are cost-effective.
DESIGN:
Risk factors were identified in Gloucestershire, UK using survival modelling. A probabilistic decision hidden (unobserved) Markov model with a misgrading matrix was developed. This informed estimation of lifetime costs and quality-adjusted life-years (QALYs) in patients without STDR. Two personalised risk stratification models were employed: two screening episodes (SEs) (low, medium or high risk) or one SE with clinical information (low, medium-low, medium-high or high risk). The risk factor models were validated in other populations.
SETTING:
Gloucestershire, Nottinghamshire, South London and East Anglia (all UK).
PARTICIPANTS:
People with diabetes in Gloucestershire with risk stratification model validation using data from Nottinghamshire, South London and East Anglia.
MAIN OUTCOME MEASURES:
Personalised risk-based algorithm for screening interval; cost-effectiveness of different screening intervals.
RESULTS:
Data were obtained in Gloucestershire from 12,790 people with diabetes with known risk factors to derive the risk estimation models, from 15,877 people to inform the uptake of screening and from 17,043 people to inform the health-care resource-usage costs. Two stratification models were developed: one using only results from previous screening events and one using previous screening and some commonly available GP data. Both models were capable of differentiating groups at low and high risk of development of STDR. The rate of progression to STDR was 5 per 1000 person-years (PYs) in the lowest decile of risk and 75 per 1000 PYs in the highest decile. In the absence of personalised risk stratification, the most cost-effective screening interval was to screen all patients every 3 years, with a 46% probability of this being cost-effective at a £30,000 per QALY threshold. Using either risk stratification models, screening patients at low risk every 5 years was the most cost-effective option, with a probability of 99-100% at a £30,000 per QALY threshold. For the medium-risk groups screening every 3 years had a probability of 43-48% while screening high-risk groups every 2 years was cost-effective with a probability of 55-59%.
CONCLUSIONS:
The study found that annual screening of all patients for STDR was not cost-effective. Screening this entire cohort every 3 years was most likely to be cost-effective. When personalised intervals are applied, screening those in our low-risk groups every 5 years was found to be cost-effective. Screening high-risk groups every 2 years further improved the cost-effectiveness of the programme. There was considerable uncertainty in the estimated incremental costs and in the incremental QALYs, particularly with regard to implications of an increasing proportion of maculopathy cases receiving intravitreal injection rather than laser treatment. Future work should focus on improving the understanding of risk, validating in further populations and investigating quality issues in imaging and assessment including the potential for automated image grading
Relation between ultrasonic properties, rheology and baking quality for bread doughs of widely differing formulation
No full textBACKGROUND
The objective was to evaluate whether an ultrasonic reflectance technique has predictive capacity for breadmaking performance of doughs made from a wide range of formulation conditions. Two flours of contrasting dough strength augmented with different levels of ingredients (inulin, oil, emulsifier or salt) were used to produce different bread doughs with a wide range of properties. Breadmaking performance was evaluated by conventional large-strain rheological tests on the dough and by assessment of loaf quality. The ultrasound tests were performed with a broadband reflectance technique in the frequency range of 0.3-6 MHz.
RESULTS
Principal component analysis (PCA) showed that ultrasonic attenuation and phase velocity at frequencies between 0.3 and 3 MHz are good predictors for rheological and bread scoring characteristics.
CONCLUSIONS
Ultrasonic parameters had predictive capacity for breadmaking performance for a wide range of dough formulations. Lower frequency attenuation coefficients correlated well with conventional quality indices of both the dough and the bread
Economic evaluation of a stratified transport method for Atlantic halibut (Hippoglossus hippoglossus) juveniles
No full textThe objective of this study was to evaluate a convenient, low-cost modification to conventional transfer methods for Atlantic halibut juveniles. A series of wire mesh cages were stacked within transport tanks creating a stratified transport system (STS), increasing the surface area for settlement and facilitating a more homogeneous distribution of halibut throughout the tank compared with the conventional insulated box (Unstructured, UTS). A stochastic cost-benefit analysis determined investment into a STS to be cost-effective, generating a mean benefit-cost ratio of 1.31 (95% CI, 0.68–2.00) after 2 years and a mean 5-year net present value of 85,176(9546,906–$125,630). The implementation of a STS was found to be technically feasible and economically efficient method to improve Atlantic halibut transport.Peter J. Sykes, Carol A. McClure, Debbie J. Martin-Robichaud, Charles G. Caraguel, K. Larry Hammel
Rent - seeking trade policy : a time series approach
No full textUsing a time-series approach, the author analyzes the relationship between the extent of rent-seeking trade policy and both political and economic variables. For rent-seeking trade policy, the indicator he uses is the number of foreign-trade regulations passed each year for the benefit of a single firm or industry. The author uses data from Uruguay for 1925-83. Uruguay, which experienced an impressive economic decline, is an outstanding example of a rent-seeking society. After being a wealthy economy in midcentury, it suffered almost complete stagnation, which led to social and policital disintegration by the end of the 1960s. Three decades of restrictive regulations on foreign trade had created a nearly closed economy by the end of the 1960s. It was worth analyzing whether policymakers'great receptiveness to demands for protection could account for Uruguay's decline. Over the period 1925-83, the author finds almost 4,000 laws, decrees, and administrative resolutions that create, maintain, or modify a foreign-trade regulation for the benefit of a single firm or industry. About half of them explicitly identify the petitioner - usually a firm or guild. Since the size of the Uruguayan economy changed over the period studied, the author scales the annual number of regulations by output or exports to measure the extent of rent-seeking trade policy. The author shows that the extent of rent-seeking trade policy increased with discretionary policies and under dictatorship. (In the period studied, there were two stages of democracy - until 1932 and from 1943-72 - and two stages of dictatorship.) He also shows that rent-seeking trade restrictions increased under import-substitution strategies and, more unexpectedly, under active export promotion. This suggests that discretionary power leads to wasteful distribution, whether it is used to support inward- or outward-oriented policies. Finally, the author analyzes the correlation between innovations in the trade policy indicator and innovations in the growth rates of output and exports, with a lag of up to 20 years. Surprisingly, he finds a positive correlation with output growth rates after two or three years. But the correlation becomes negative some years later, particularly in the case of exports. The short-run positive impact on growth rates, together with the surprisingly long time lag before the negative impact, may account for policymakers'receptiveness to demands for protection.Trade Policy,Achieving Shared Growth,TF054105-DONOR FUNDED OPERATION ADMINISTRATION FEE INCOME AND EXPENSE ACCOUNT,Economic Theory&Research,Environmental Economics&Policies
Flexible Mx Specification of Various Extended Twin Kinship Designs
No full textThe extended twin kinship design allows the simultaneous testing of additive and nonadditive genetic, shared and individual-specific environmental factors, as well as sex differences in the expression of genes and environment in the presence of assortative mating and combined genetic and cultural transmission (Eaves et al., 1999). It also handles the contribution of these sources of variance to the (co)variation of multiple phenotypes. Keller et al. (2008) extended this comprehensive model for family resemblance to allow or a flexible specification of assortment and vertical transmission. As such, it provides a general framework which can easily be reduced to fit subsets of data such as twin-parent data, children-of-twins data, etc. A flexible Mx specification of this model that allows handling of these various designs is presented in detail and applied to data from the Virginia 30,000. Data on height, body mass index, smoking status, church attendance, and political affiliation were obtained from twins and their families. Results indicate that biases in the estimation of variance components depend both on the types of relative available for analysis, and on the underlying genetic and environmental architecture of the phenotype of interest. Author(s): Hermine H. Maes 1 * | Michael C. Neale 2 | Sarah E. Medland 3 | Matthew C. Keller 4 | Nicholas G. Martin 5 | Andrew C. Heath 6 | Lindon J. Eaves
Martin Buber: Guide for a psychology of suffering
No full textMartin Buber was untrained in psychology, yet his teaching provides helpful guidance for a psychological science of suffering. His ideas deserve attention at three distinct levels. For each of these, his ideas align with research findings, but also push beyond them. At the individual level, Buber’s radical approach to relationships disrupts typical social cognitive cycles of suffering and can thereby build a defense against suffering. At the community level, he provides guidance that can help create a society that cares for people who suffer. At the dyadic level, Buber’s guidance also matters. His ideas point toward a therapeutic dyad that can help address suffering when the individual and community responses are not sufficient. Specifically, he guides us toward a holistic view of the person that transcends labels and also toward ineffable human relations. Here again, his ideas align with empirical research, but push beyond. Buber’s unique take on relationships has much to offer scholars seeking to understand and alleviate suffering. Some might perceive Buber as ignoring evil. That possible criticism and others deserve consideration. Nonetheless, readiness to adjust theory in response to Buber and other psychological outsiders may be valuable when developing a psychology of suffering.Peer reviewedMartin Buberdialoguesufferingguidepsychologypositive psycholog
Adapting musicology's use of affect theories to contemporary theatre making: Directing Martin Crimp's attempts on her life
No full textCopyright @ Intellect 2011Adopting and adapting musicology's use of affect theories, specifically Jeremy Gilbert's idea of an 'affective analysis' and David Epstein's idea of 'shaping affect', this article looks at Martin Crimp's Attempts on Her Life from a practitioner's perspective. It investigates the challenges and benefits of adopting an 'affective approach' to directing recent theatre texts that stress the musicality and corporeality of language along with, and at times above, its signifying roles. Rather than locating Aristotelian dramatic climaxes based on narratological or characterological progression, an affective approach seeks to identify moments of affective intensity, which produce a different sort of impact by working on a 'body-first' methodology, rather than the directly cerebral. That this embodied impact is not ultimately meaningless is one of affect theory's most vital assertions. This approach has resonance in terms of how directors, performers and critics/theorists approach work of this type
Austrian economics: a tale of lost opportunities
No full textThis is a, somewhat indirect, rejoinder to Boettke (2019, this volume, Chapter 1). Doing Austrian economics is low prestige: Austrian economics does not get published in high-prestige journals and Austrian economists are not employed by top universities. And yet, up until World War II Austrian economics was an important part of the international economics community. The author argues that Austrian economists made several theoretical innovations that could have placed them at the frontier of research in economics, and present a brief coun-terfactual history of a thriving Austrian economics based on those innovations. However, the actual history of the Austrian School is quite different. A par-ticularly decisive factor that has made Austrian economics a fringe movement was the rejection of formal methods in theory and empirics. The author argues that Austrian economics is basically dying out as a voice in the conversation of modern economists
The Euler charateristic of the generalized Kummer scheme of an Abelian threefold
No full textLet X be an Abelian threefold. We prove a formula, conjectured by the first author, expressing the Euler characteristic of the generalized Kummer schemes of X in terms of the number of plane partitions. This computes the Donaldson-Thomas invariant of the moduli stack [(KX)-X-n / X-n]
- …
