846 research outputs found
Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide
No full textCovalently cross-linked homodimeric Aβ peptides have been prepared by solid-phase peptide synthesis by exploiting ‘site–site interactions’, and exhibit substantially increased oligomerisation and fibrillisation properties compared with the corresponding monomers.W. Mei Kok, Denis B. Scanlon, John A. Karas, Luke A. Miles, Deborah J. Tew, Michael W. Parker, Kevin J. Barnham and Craig A. Hutto
Electron transfer through alpha-peptides attached to vertically aligned carbon nanotube arrays: a mechanistic transition
No full textThis article is part of the Artificial photosynthesis web themed issueThe mechanism of electron transfer in α-aminoisobutyric (Aib) homoligomers is defined by the extent of secondary structure, rather than just chain length. Helical structures (Aib units ≥3) undergo an electron hopping mechanism, while shorter disordered sequences (Aib units <3) undergo an electron superexchange mechanism.Jingxian Yu, Ondrej Zvarec, David M. Huang, Mark A. Bissett, Denis B. Scanlon, Joe G. Shapter and Andrew D. Abel
Total synthesis of the antifungal depsipeptide petriellin A
No full textPublication Date (Web): July 8, 2011We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected linear precursor, which was cleaved from the solid support prior to cyclization and final deprotection. Use of advanced coupling agents for several hindered amides was a feature of the synthesis. The natural product was prepared in overall 5% yield.Marianne M. Sleebs, Denis Scanlon, John Karas, Rani Maharani, and Andrew B. Hughe
Functional fibrils derived from the peptide TTR1-cycloRGDfK that target cell adhesion and spreading
No full textPeptide self-assembly offers a route for the production of fibrous nanomaterials with advanced bioactive properties that promote specific cell interactions. In this study the peptide TTR1-cycloRGDfK was designed to form amyloid-like fibrils that display the functional cyclic RGDfK pentapeptide ligand to target mammalian cell surface α(V)β₃ integrin receptors. The TTR₁₀₅₋₁₁₅ (or TTR1) sequence was used as the self-assembling domain. Once assembled, TTR1-cycloRGDfK fibrils display a characteristic cross-β core structure by X-ray fibre diffraction that was preserved following dehydration. Thin films of fibrils were characterised by infrared synchrotron mapping, scanning electron microscopy and atomic force microscopy. Cell adhesion and spreading were promoted on thin films of TTR1-cycloRGDfK fibrils via specific interactions with the cyclic RGDfK ligand. Low levels of non-specific interactions were also observed between cells and non-functionalised fibrils. TTR1-cycloRGDfK fibrils are an advance on bioactive fibrils previously designed to interact with a range of RGD binding integrins and our findings show that the assembly of amyloid-like fibrils based on the TTR1 sequence is robust and can be directed to form materials with specific properties.Marie N. Bongiovanni, Denis B. Scanlon, Sally L. Gra
Justice, droit, police (1930-1960) (12) - face B
No full textSéminaire dirigé par Alain Bancaud, Anne Boigeol, Denis Peschanski et Henry Rousso. Enregistré à l'IHTP (Paris), entre 1993 et 1994
Justice, droit, police (1930-1960) (06) - face B
No full textSéminaire dirigé par Alain Bancaud, Anne Boigeol, Denis Peschanski et Henry Rousso. Enregistré à l'IHTP (Paris), entre 1993 et 1994
Justice, droit, police (1930-1960) (10) - face B
No full textSéminaire dirigé par Alain Bancaud, Anne Boigeol, Denis Peschanski et Henry Rousso. Enregistré à l'IHTP (Paris), entre 1993 et 1994
Justice, droit, police (1930-1960) (05) - face B
No full textSéminaire dirigé par Alain Bancaud, Anne Boigeol, Denis Peschanski et Henry Rousso. Enregistré à l'IHTP (Paris), entre 1993 et 1994
Justice, droit, police (1930-1960) (09) - face B
No full textSéminaire dirigé par Alain Bancaud, Anne Boigeol, Denis Peschanski et Henry Rousso. Enregistré à l'IHTP (Paris), entre 1993 et 1994
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