92,747 research outputs found
Scanlan, E T (Eric Thomas), VX65951
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/415531Surname: SCANLAN. Given Name(s) or Initials: E T (ERIC THOMAS). Military Service Number or Last Known Location: VX65951. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 42608.236177
Item: [2016.0049.47792] "Scanlan, E T (Eric Thomas), VX65951
Biosynthesis of 3-Iodothyronamine (T1AM) is dependent on the sodium-iodide symporter and thyroperoxidase but does not involve extrathyroidal metabolism of T4
No full text3-Iodothyronamine (T1AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T1AM is an extrathyroidal metabolite of T 4. This study uses an isotope-labeled T4 [heavy-T 4 (H-T4)] that can be distinguished from endogenous T 4 by mass spectrometry, which allows metabolites to be identified based on the presence of this unique isotope signature. Endogenous T 1AM levels depend upon thyroid status and decrease upon induction of hypothyroidism. However, in hypothyroid mice replaced with H-T4, the isotope-labeled H-T3 metabolite is detected, but no isotope-labeled T1AM is detected. These data suggest that T1AM is not an extrathyroidal metabolite of T4, yet is produced by a process that requires the same biosynthetic factors necessary for T4 synthesis
Design and flight test of a civil unmanned aerial vehicle for maritime patrol: the use of 3D-printed structural components
No full textThis paper describes the design of the “Spotter” unmanned aerial vehicle, developed by the University of Southampton as part of the 2SEAS-3i European Interreg project. Spotter is a twin engine, 4m wing span, fixed-wing aircraft which has been designed to perform long-endurance, all-weather patrol missions in coastal and maritime environments. Reliability and safety have been among the strongest design drivers of this project; Spotter is able to survive the failure of one engine and of any single control surface. A modular approach has been adopted for the payload unit in order to allow the users to rapidly interchange the sensors required to perform different missions.One of the most innovative aspects of Spotter is the extensive use of the Selective Laser Sintering (SLS) technology (also known as 3D printing) for many of the components of its airframe. By eliminating tooling and manual labour, the 3D printing technology allows the designer to produce complex and high-performance structures at a relatively low cost and within hours of the completion of the design. Spotter and a sub-20kg version, codenamed 2SEAS-20, have undergone an extensive flight test campaign, totalling hundreds of autonomous flights (including autonomous take-off and landings) and many flight hours. This has provided the opportunity to test the reliability and robustness of the system and to gain a deeper insight into the opportunities and problems presented by the use of 3D printed structures for large airframe components
Modeling of modulus graded axisymmetric adhesive joints
No full textThis study presents a refined theoretical framework for the stress analysis of modulus graded axisymmetric adhesive joints which takes into account the radial stresses in the bonded assembly. This semi-analytical is based on a variational method which minimizes the complementary energy of the bonded system. The joint consists of similar or dissimilar polar anisotropic composite adherends or metallic adherends and a functionally modulus graded bondline (FMGB) adhesive. The elastic modulus of the adhesive is functionally graded along the bondlength by assuming smooth modulus profiles which reflect the behavior of practically producible graded bondline. The stress distribution predicted by this refined model is compared with that of MMB model which also accounts for in the bonded system to estimate reduction in shear and peel stress peaks in the bondline. The axisymmetric stress analysis reveals that the peel and shear stress peaks in the FMGB are much smaller and the stress distribution is more uniform along its length than those of mono-modulus bondline (MMB) adhesive joints under the same axial tensile load. A systematic parametric study has been conducted by selectively perturbing the material and geometrical properties of the joint in order to study their influence onstress distribution in the bondline. Furthermore, the results suggest that the peel and shear strengths can be optimized by spatially controlling the modulus of theadhesive
The TRbeta-selective agonist, GC-1, stimulates mitochondrial oxidative processes to a lesser extent than triiodothyronine
No full textJ Endocrinol. 2010 Jun;205(3):279-89. Epub 2010 Apr 1.
The TRbeta-selective agonist, GC-1, stimulates mitochondrial oxidative processes to a lesser extent than triiodothyronine.
Venditti P, Chiellini G, Di Stefano L, Napolitano G, Zucchi R, Columbano A, Scanlan TS, Di Meo S.
SourceDipartimento delle Scienze Biologiche, Sezione di Fisiologia, Università di Napoli Federico II, Via Mezzocannone 8, I-80134 Napoli, Italy. [email protected]
Abstract
Specific tissue responses to thyroid hormone are mediated by the hormone binding to two subtypes of nuclear receptors, TRalpha and TRbeta. We investigated the relationship between TRbeta activation and liver oxidative metabolism in hypothyroid rats treated with equimolar doses of triiodothyronine (T(3)) and GC-1, a TRbeta agonist. T(3) treatment produces increases in O(2) consumption and H(2)O(2) production higher than those elicited by GC-1. The greater effects of T(3) on oxidative processes are linked to the higher hormonal stimulation of the content of respiratory chain components including autoxidizable electron carriers as demonstrated by the measurement of activities of respiratory complexes and H(2)O(2) generation in the presence of respiratory inhibitors. It is conceivable that these differential effects are dependent on the inability of GC-1 to stimulate TRalpha receptors that are likely involved in the expression of some components of the respiratory chain. The greater increases in reactive oxygen species production and susceptibility to oxidants exhibited by mitochondria from T(3)-treated rats are consistent with their higher lipid and protein oxidative damage and lower resistance to Ca(2)(+) load. The T(3) and GC-1 effects on the expression levels of nuclear respiratory factor-1 and -2 and peroxisome proliferator-activated receptor-gamma coactivator-1alpha suggest the involvement of respiratory factors in the agonist-linked changes in mitochondrial respiratory capacities and H(2)O(2) production.
PMID:20360308[PubMed - indexed for MEDLINE
Evaluating design decisions in real-time using operations modelling
No full textContemporary design processes of large aerospace products are rigidly focused on customer specifications in order to meet their expectations. Life cycle costs, design space exploration and value engineering are neglected, often leading to substantial cost overruns and delivery delays. Moreover, customer specifications are not scrutinized and design decisions are made ignoring potential operational knowledge. Value-driven design suggests a new approach using flexible customer specifications in order to find optimal designs by exploring the solution space. One aspect of this optimization is the simulation of the anticipated operational life of a product in order to gain operational knowledge and analyse customer specifications. This paper suggests that an operational simulation can be used actively or reactively by designers during the design process to improve a product. It is investigated how an operational simulation can act as a design decision support tool and how it can react to customer specifications. Answers are presented by means of a simulation model recreating the operational life of a Search-and-Rescue Unmanned Air Vehicle developed in parallel at the University of Southampton. The simulation's ability for acting as a decision support tool is explored by conducting a fuel tank size optimization. Reactive capabilities are explored by calculating the surplus value of using UAVs. This exemplifies the derivation of product specifications as the simulation reveals the value and hence usefulness of given customer specifications. It is shown that operational simulations benefit designers and overall product value by analysing product specifications and guiding designers to more informed design decision
On axisymmetric adhesive joints with graded interface stiffness
No full textAn improved analytical model is presented for the stress analysis of interface stiffness graded axisymmetric adhesive joints. The governing integro-differential equation of the problem is obtained through a variational method which minimizes the complementary energy of the bonded assembly. The joint is composed of similar or dissimilar polar anisotropic and/or isotropic adherends and a functionally modulus graded bondline (FMGB) adhesive. The elastic modulus of the adhesive is functionally graded along the bondlength by assuming smooth modulus profiles which reflect the behavior of practically producible graded bondline. Influence of non-zero radial stresses in the bonded system on shear and normal stresses is evaluated. The stress distribution predicted by this refined model is compared with that of mono-modulus bondline (MMB) model for the same axial tensile load in order to estimate reduction in shear and normal stress peaks in the bondline and the adherends. A systematic parametric study indicates that an optimum joint strength can be achieved by employing a stiffness graded bondline with an appropriate combination of geometrical and material properties of the adherends. This model can also be applied to examine the effects of loss of interface stiffness due to an existing defect and/or damage in the bondlin
1.07 – Structure and biosynthesis of glycoprotein carbohydrates
No full textIn eukaryotes, the majority of cell surface and secreted proteins are covalently modified with carbohydrates. This type of posttranslational modification, glycosylation, is inherently complex exhibiting extensive chemical and conformational heterogeneity. Despite this complexity, there are common structural and biosynthetic principles. Here, we present an introduction to the different hierarchies of carbohydrate structure from stereochemistry of monosaccharides and their linkages to the structural diversity of complex mammalian glycosylation. These structures are discussed in the context of the glycan biosynthetic pathways, with an emphasis on N-linked glycosylation, and we outline the nomenclature with which these complex structures can be described. We describe the biosynthesis and crystal structures of antibodies and their glycans to illustrate the conformational properties of glycoprotein carbohydrates and how therapeutic antibodies are being developed by modulating these glycans.</p
Mapping customer needs to engineering characteristics: an aerospace perspective for conceptual design
No full textDesigning complex engineering systems, such as an aircraft or an aero-engine, is immensely challenging. Formal Systems Engineering (SE) practices are widely used in the aerospace industry throughout the overall design process to minimise the overall design effort, corrective re-work, and ultimately overall development and manufacturing costs. Incorporating the needs and requirements from customers and other stakeholders into the conceptual and early design process is vital for the success and viability of any development programme. This paper presents a formal methodology, the Value-Driven Design (VDD) methodology that has been developed for collaborative and iterative use in the Extended Enterprise (EE) within the aerospace industry, and that has been applied using the Concept Design Analysis (CODA) method to map captured Customer Needs (CNs) into Engineering Characteristics (ECs) and to model an overall ‘design merit’ metric to be used in design assessments, sensitivity analyses, and engineering design optimisation studies. Two different case studies with increasing complexity are presented to elucidate the application areas of the CODA method in the context of the VDD methodology for the EE within the aerospace secto
Rapid development of bespoke sensorcraft: a proposed design loop
No full textThe ability to quickly fabricate sensorcraft, or other small unmanned aircraft, via additive manufacturing techniques opens a range of new possibilities for the design and optimization of these vehicles. In this paper we propose a design loop that makes use of surrogate modeling and additive manufacturing to reduce the design and optimization time of scientific sensorcraft. Additive manufacturing reduces the time and effort required to fabricate a complete aircraft, allowing design iterations to be quickly manufactured and flight tested. Co-Kriging surrogate models allow data collected from test flights to correct Kriging models trained with numerically simulated data. The resulting model provides physically accurate and computationally cheap aircraft performance predictions. A global optimizer is used to search this model to find an optimal design for a bespoke aircraft. This paper presents the design loop and the progress made in implementing this design loop. Results are shown from Kriging models trained using numerically simulated data. Progress towards extracting aerodynamic data from flight testing small unmanned aircraft is also documented
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