1,721,085 research outputs found
Effects of caffeine on the cell cycle progression and on the production of chromosomal aberrations in human lymphocytes treated with MMC in Go and in G1
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Chromosomal aberrations induction of o-phenylen-diamine in mouse bone marrow cells and in human lymphocytes
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Enhanced expression of common fragile sites with occupational exposure to pesticides
No full textThe expression of common fragile sites (FS), induced by aphidicolin, in subjects with occupational history of exposure to pesticides has been studied. Results showed a higher frequency of FS in exposed subjects; in particular, there was an elevated expression of FS at the cancer breakpoints 3p14, 5q31, 7q22, 7q32, 14q24, and 16q22, involved in leukemias and non-Hodgkin's lymphoma. Moreover, the frequency of breaks in chromosomal bands carrying oncogenes or tumor suppressor genes involved in aberrations was significantly higher in exposed subjects at sites 1q25, 3p25, 7p22, 8q24.1, and 13q14
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