186,240 research outputs found
Igloo-like prepuce: a peculiar aspect of smooth-muscle hamartoma of the genitalia?
No full textWe report the case of a 16-year-old boy with 'igloo-like prepuce' and hypospadia, successfully treated by asymmetrical antero-posterior postectomy. Histopathological examination consisting of classical microscopy, immuno-histochemistry and electronmicroscopy of the surgical material provided insights into the etiopathogenesis of this rare disease
A case of disseminated granuloma annulare treated with defibrotide: complete clinical remission and progressive hair darkening
No full textMalignant nodular hidradenoma of the skin: report of seven cases
No full textBackground: Malignant nodular hidradenoma (MNH) is an infrequent, highly malignant, primary skin tumour derived from eccrine sweat glands. Most tumours occur in elderly individuals. MNH has very poor prognosis, high recurrence and a high rate of metastases. The best method of treatment is still unclear: radical surgical excision is widely used, and selective lymph node dissection is also suggested. The value of the adjuvant radiotherapy and chemotherapy has not been confirmed. Patients and treatment: Seven MNH patients (4 men, 3 women, age 60-87.years) were treated between 1991 and 2007 in the Dermatology Unit of San Donato Hospital of Arezzo and in the Section of Dermatology of University of Siena, Italy. Tumours varied from 0.8 to 4.4.cm in size. All patients underwent local excision; five also had lymph node dissection. One patient underwent adjuvant radiotherapy, and three received chemotherapy. Results: Six of seven patients died, with survival varying from 15 to 45.months. Distant metastases occurred in two patients. Survival time was inversely proportional to the size of the tumour. Conclusions: MNH is an aggressive tumour and should be diagnosed and excised as early as possible. Histological parameters are paramount, but correct diagnosis also calls for attention to clinical presentation and any history of recurrence or recent enlargement of long-standing lesions. In our experience, radiotherapy and chemotherapy do not seem to prolong survival. © 2007 The Authors Journal compilation © 2007 European Academy of Dermatology and Venereology
A case of Darier's disease successfully treated with topical tacrolimus
No full textTacrolimus is a macrolide that inhibits T-cell activation. The most extensive experience with topical tacrolimus has been in treating atopic dermatitis but it has been used in various skin diseases, including Hailey-Hailey disease, with encouraging results. We report a case of extensive Darier's disease successfully treated with topical tacrolimus, after suspension of oral isotretrinoin due to major depression
Case 4. Umbilical endometriosis
No full textA 28‐year‐old Caucasian woman presented with a nodule in the umbilicus at week 12 of pregnancy. She had a 2‐year history of intermittent pain and bleeding from the umbilicus. The lesion also bled during pregnancy. Examination revealed a tender, reddish‐brown polypoid nodule, 1 × 1 cm in diameter, in the umbilicus (Fig. 1). Medical and surgical history revealed nothing of note. Histological examination of a haematoxylin and eosin‐stained biopsy specimen showed a mass of polygonal cells with abundant cytoplasm rich in eosinophils and spaces lined with flat and, in places, simple cuboid epithelial cells in the dermis (Fig. 2)
Terbinafine-induced acute generalized exanthematous pustulosis
No full textTerbinafine is an allylamine antifungal agent, effective in the treatment of dermatomycoses. Many cutaneous adverse reactions have been reported (in about 3% of treated patients). Furthermore terbinafine has been associated with pustular eruptions, as well as the induction and exacerbation of pre-existing psoriasis and acute generalized exanthematous pustulosis (AGEP). AGEP is an uncommon aseptic pustular eruption, classified for many years as a pustular psoriasis, that usually follows recent administration of oral or parenteral drugs. The disease is most frequently triggered by antibiotics, most of all aminopenicillins and macrolides. Characteristic AGEP features include the sudden onset of fever above 38 C with widespread erythematous eruption, rapidly progressing to a fine, non-follicular, micropustular rash. Leucocytosis is generally present, sometimes associated with eosinophilia. The illness usually resolves spontaneously with the fever and the pustulation clearing within 15 days, sometimes followed by desquamation. Hystopathology shows non-follicular spongiotic pustules in the epidermis filled with neutrophils, a mixed perivascular infiltrate of neutrophils and occasional eosinophils with papillary dermal oedema. On this subject, Sideroff et al. recently elaborated a validation score based on morphology, histological criteria, and disease course. The pathogenetic mechanism which leads to the induction of AGEP by some medicines has still not been clarified, but T cells seem to play a crucial role. The authors report a case of a patient with terbinafine-induced AGEP and a review of the literature about this topic. The case illustrates once again the role of terbinafine in AGEP and reminds us that early diagnosis of AGEP is important to avoid unnecessary investigations and/or the administration of antibiotics
Digital dermoscopy analysis and internet-based program for discrimination of pigmented skin lesion dermoscopic images
No full textReply to 'Digital dermoscopy analysis and internet-based program for discrimination of pigmented skin lesion dermoscopic images
A case of reticular erythematous mucinosis treated with topical tacrolimus
No full textTacrolimus was found to be a safe and valid alternative to systemic antimalarials in our patient
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