3,258 research outputs found
Dorothy L Sayers: creative mind and the holy trinity
No full textHuman beings have no language with which to speak about God and their experiences of God except that language which they also use of themselves and of their experiences of each other. The doctrine of the Trinity points to the presence and action of God in the world through Jesus Christ. The search for human analogies with the doctrine of the Trinity has occupied the minds and hearts of theologians and philosophers since earliest Christian times. Many of the attempts made to provide a paradigm by which the Holy Trinity might best be articulated in human thinking have fallen short of the ideals at which they aimed. As a result, there is a paucity of material from which the teacher of theology may draw in explicating this apparently most complicated of doctrines. While the search was confined to the field of pure theology, it seemed fruitless. Dorothy L Sayers, a writer of detective novels, engaged in that search almost by accident as she moved from detective fiction to religious drama in the second phase of her writing career. By using her own experience of creative activity, she saw a striking resemblance between the creative activity of God and that of God's creatures. That this activity possessed a threefold structure allowed Sayers to discern a human analogy with the doctrine of the Trinity which would serve where others had failed. Her thinking was set out in her book The Mind of the Maker in 1941. However, her achievement in this volume has largely been ignored. It is time for a re-appraisal of that achievement in order both to re-present it to those engaged in theological deliberations now and to investigate how it was received in its own day and why it may have been overlooked hitherto
Regulation and privatisation in the Australian waterfront industry
No full texttag=1 data=Regulation and privatisation in the Australian waterfront industry
tag=2 data=Sayers, Christopher R.
tag=3 data=Australian Transport Research Forum (13th : 1988 : Christchurch NZ)
tag=6 data=^d ^m ^y1988
tag=8 data=PORTS & HARBOURS
tag=10 data=Extracted from a book
tag=15 data=BOOExtracted from a boo
Dorothy L. Sayers and the Inklings
No full textNotes known connections to Lewis and Williams on Sayers’s part (through the evidence of letters). Speculates on ways they may have influenced each other. Includes an excerpt from a Sayers letter on the Narnia books
The resistance of cortical bone tissue to failure under cyclic loading is reduced with alendronate
No full textBisphosphonates are the most prescribed preventative treatment for osteoporosis. However, their long-term use has recently been associated with atypical fractures of cortical bone in patients who present with low-energy induced breaks of unclear pathophysiology. The effects of bisphosphonates on the mechanical properties of cortical bone have been exclusively studied under simple, monotonic, quasi-static loading. This study examined the cyclic fatigue properties of bisphosphonate-treated cortical bone at a level in which tissue damage initiates and is accumulated prior to frank fracture in low-energy situations. Physiologically relevant, dynamic, 4-point bending applied to beams (1.5 mm × 0.5 mm × 10 mm) machined from dog rib (n=12/group) demonstrated mechanical failure and micro-architectural features that were dependent on drug dose (3 groups: 0, 0.2, 1.0mg/kg/day; alendronate [ALN] for 3 years) with cortical bone tissue elastic modulus (initial cycles of loading) reduced by 21% (p<0.001) and fatigue life (number of cycles to failure) reduced in a stress-life approach by greater than 3-fold with ALN1.0 (p<0.05). While not affecting the number of osteons, ALN treatment reduced other features associated with bone remodeling, such as the size of osteons (-14%; ALN1.0: 10.5±1.8, VEH: 12.2±1.6, ×10(3) μm2; p<0.01) and the density of osteocyte lacunae (-20%; ALN1.0: 11.4±3.3, VEH: 14.3±3.6, ×10(2) #/mm2; p<0.05). Furthermore, the osteocyte lacunar density was directly proportional to initial elastic modulus when the groups were pooled (R=0.54, p<0.01). These findings suggest that the structural components normally contributing to healthy cortical bone tissue are altered by high-dose ALN treatment and contribute to reduced mechanical properties under cyclic loading conditions.NOTICE: this is the author's version of a work that was accepted for publication in Bone. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bone, Volume 64 (July 2014) DOI: 10.1016/j.bone.2014.03.045Peer reviewe
American Society of Biomechanics Journal of Biomechanics Award 2013: Cortical bone tissue mechanical quality and biological mechanisms possibly underlying atypical fractures
No full textThe biomechanics literature contains many well-understood mechanisms behind typical fracture types that have important roles in treatment planning. The recent association of "atypical" fractures with long-term use of drugs designed to prevent osteoporosis has renewed interest in the effects of agents on bone tissue-level quality. While this class of fracture was recognized prior to the introduction of the anti-resorptive bisphosphonate drugs and recently likened to stress fractures, the mechanism(s) that lead to atypical fractures have not been definitively identified. Thus, a causal relationship between these drugs and atypical fracture has not been established. Physicians, bioengineers and others interested in the biomechanics of bone are working to improve fracture-prevention diagnostics, and the design of treatments to avoid this serious side-effect in the future. This review examines the mechanisms behind the bone tissue damage that may produce the atypical fracture pattern observed increasingly with long-term bisphosphonate use. Our recent findings and those of others reviewed support that the mechanisms behind normal, healthy excavation and tunnel filling by bone remodeling units within cortical tissue strengthen mechanical integrity. The ability of cortical bone to resist the damage induced during cyclic loading may be altered by the reduced remodeling and increased tissue age resulting from long-term bisphosphonate treatment. Development of assessments for such potential fractures would restore confidence in pharmaceutical treatments that have the potential to spare millions in our aging population from the morbidity and death that often follow bone fracture.Peer reviewe
Reviews
No full textDark Wood to White Rose: A Study of Meanings in Dante\u27s Divine Comedy. Helen M. Luke. Reviewed by Joe R. Christopher.
The Singer. Calvin Miller. Reviewed by George Colvin.
The Emperor Constantine: A Chronicle. Dorothy L. Sayers. Reviewed by George Colvin.
Mithrandir. Stephen O. Miller, illus. by Jean Brill. Reviewed by Nancy-Lou Patterson.
Middle Earth—A World in Conflict. Stephen O. Miller, illus. by James Shull. Reviewed by Nancy-Lou Patterson
The evolution of central banking
No full textInstitutions known as central banks emerged or were established as commercial banks or government banks. Their evolution into central banks came with their monopoly issuing notes and their role as lender of last resort, among other functions. Carrying out commercial business on a large scale created a conflict of interest, so this practice was abandoned. Establishing the right degree of dependence was difficult, and changed in times of crisis. Independence is important: it helps to establish reputation, which is everything in banking. The Great Depression, widely attributed to inept Central Bank behavior, interrupted central bank independence, but poor price behavior brought about its return. In the 19th century, laissez faire and the gold standard encouraged and sometimes allowed for considerable independence. Greater changes came in the new dirigiste environment following the Great Depression and the rise of the managed economy. Economies in transition confront high inflation and the problem of maintaining monetary stability just as newly independent developing countries did in the 1960s. How can inflation be controlled? Under fiat regimes, the money supply is controlled by the domestic monetary authority. But can they control monetary growth? Prior and current records are not encouraging. Will authorities have the credibility they need? Options include maintaining a fixed exchange rate or reviving currency boards. Currency boards function like an independent central bank, holding reserves and tying domestic currency to strong foreign currency. There are drawbacks to currency boards, especially for countries in transition. They require a considerable sacrifice of sovereignty, and are unlikely to appeal to countries that are only beginning to recover lost sovereignty.Financial Intermediation,Payment Systems&Infrastructure,Banks&Banking Reform,Economic Theory&Research,Financial Crisis Management&Restructuring,Banks&Banking Reform,Economic Stabilization,Financial Intermediation,Economic Theory&Research,Financial Crisis Management&Restructuring
Detecting intestinal ischemia using near infrared spectroscopy
No full textBlood supply to the intestine can suddenly be interrupted. Acute mesenteric intestinal ischemia often requires invasive surgery to restore blood supply to the intestine. Early correction of vascular insufficiency is the most important factor in improving patient survival when confronted with acute mesenteric intestinal ischemia. A prolonged loss of blood flow results in irreversible damage to the intestine that can lead to death. It is also imperative that dead segments of the intestines be removed. Several subjective criteria are relied upon to differentiate viable from non-viable tissue, unfortunately, these criteria can lead to an inaccurate assessment. A porcine model of intestinal ischemia was used to determine the efficacy of using near infrared (NIR) spectroscopy to find ischemic segments of the intestine and detect the onset of reperfusion following resolution of vascular occlusion. Nine segments of intestine were identified and six were assigned to three treatment groups; (1) segments undergoing no vascular manipulations, (2) segments undergoing arterial/venous occlusion and (3) segments undergoing arterial/venous occlusion followed by reperfusion. The remaining segments were used as spacers and interposed between each of the ischemia segments. A classification model, using partial least square discriminant analysis, was built on the spectra collected from the segments with no vascular manipulations and the segments that were solely subjected to arterial/venous occlusion. The spectra collected from the intestinal segments that experienced both occlusion and reperfusion were used to test the classification model. The model was able to detect and distinguish ischemic intestinal tissue with a specificity and sensitivity exceeding 80% with an overall classification accuracy of 89%. The method appears to be well suited as an intra-operative assessment method when intestinal ischemia is a concern.Michael G. Sowa, Elicia Kohlenberg, Jeri R. Payette, Lorenzo Leonardi, Michelle A. Levasseur and Christopher B. Rile
Theology in suspense : how the detective fiction of P.D. James provokes theological thought
No full textElectronic redacted version excludes material for which permission has not been granted by the rights holderThe following dissertation argues that the detective fiction of P.D. James
provokes her readers to think theologically. I present evidence from the body of
James’s work, including her detective fiction that features the Detective Adam
Dalgliesh, as well as her other novels, autobiography, and non-fiction work. I also
present a brief history of detective fiction. This history provides the reader with a
better understanding of how P.D James is influenced by the detective genre as well as
how she stands apart from the genre’s traditions.
This dissertation relies on an interview that I conducted with P.D. James in
November, 2008. During the interview, I asked James how Christianity has
influenced her detective fiction and her responses greatly contribute to this
dissertation. However, James’s novels should be interpreted and explored in the
manner that they are received by the reader. How the reader receives and responds to
the novels, not only how James writes the novels, is what causes her stories to
provoke theological thinking.
By examining Christian symbolism that is present in setting, character, the
Detective Adam Dalgliesh, and plot, this dissertation seeks to assert that James
contributes to a theological conversation through her popular detective fiction
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