3,307 research outputs found
Cobalt(III)-Catalyzed C–H Alkynylation with Bromoalkynes under Mild Conditions
No full textExpedient cobalt-catalyzed C-H alkynylation was achieved under exceedingly mild reaction conditions. Thus, chelation-assisted direct alkynylations of heteroarenes occurred with 1-bromoalkynes and ample substrate scope. The optimized catalytic system allowed for step-economical C-H functionalizations with a mild base K2CO3 at reaction temperatures as low as 25 degrees C
ChemInform Abstract: Cobalt(III)‐Catalyzed C—H Alkynylation with Bromoalkynes under Mild Conditions.
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Manganese-Catalyzed C−H Alkynylation: Expedient Peptide Synthesis and Modification
No full textManganese(I)-catalyzed C-H alkynylations with organic halides occurred with unparalleled substrate scope, and thus enabled step-economical C-H functionalizations with silyl, aryl, alkenyl, and alkyl haloalkynes. The versatility of the manganese(I) catalysis manifold enabled C-H couplings with haloalkynes featuring, among others, fluorescent labels, steroids, and amino acids, thereby setting the stage for peptide ligation as well as the efficient molecular assembly of acyclic and cyclic peptides. A plausible catalytic cycle was proposed
ChemInform Abstract: C—H Alkenylations with Alkenyl Acetates, Phosphates, Carbonates, and Carbamates by Cobalt Catalysis at 23 °C.
No full textElectroremovable Traceless Hydrazides for Cobalt-Catalyzed Electro-Oxidative C–H/N–H Activation with Internal Alkynes
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CH Alkenylations with Alkenyl Acetates, Phosphates, Carbonates, and Carbamates by Cobalt Catalysis at 23 degrees C
No full textInexpensive cobalt catalysts with N-heterocyclic carbene ligands enable direct arene alkenylations with easily accessible alkenyl acetates through regioselective CH/CO functionalizations in a stereoconvergent fashion. The versatile cobalt catalyst was broadly applicable and thus also allowed for the efficient conversion of alkenyl phosphates, carbonates, and carbamates at ambient temperature.European Research Council under the European Community [307535
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