1,720,997 research outputs found
“TWO‐STEP” PEMPHIGUS INDUCTION BY ACE‐INHIBITORS
No full textPemphigus lesions appeared in a 58‐year‐old man who was talking captopril for his hypertension. Drug withdrawal resulted in complete remission of the eruption. The subsequent use of enalapril as an antihypertensive agent caused a recurrence of pemphigus lesions along with onset of itching and dermographism. Intercellular antibodies were not found. Discontinuance of enalapril therapy had no effect on the clinical course. Steroid treatment was needed to resolve the eruption. Recently repeated immunofluorescent studies disclosed intercellular IgG antibodies in the serum at a low titer. Pemphigus induction could be initially related to the thiol acantholytic property of captopril. Subsequent production of intercellular antibodies and drug‐activation of the kinin system could be responsible for relapsing. Copyright © 1992, Wiley Blackwell. All rights reserve
Hereditary benign intraepithelial dyskeratosis
No full textHereditary benign intraepithelial dyskeratosis, a very rare disease affecting oral and conjunctival mucosae, is often familial and is determined by an autosomal dominant gene. Seven subjects belonging to three generations of a Neapolitan family presented the disease with a different expressivity. Cytohistological aspects and differential diagnosis are pointed out
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