2 research outputs found
Synthesis Of Substituted (4(1H-Indol-3-Yl)Butanoyl)-2-(1H-4-Indol-4-Ylidene)-N-(4hydroxybenzyl)Hydrazine-1-Carboxamide And It’s Anti-Inflammatory Studies
No full textBased on the provided context, a series of new indole-hydrazone derivatives were synthesized and their structures were determined through elemental and spectral studies. These synthesized compounds were then tested for their anti-inflammatory activity using carrageenan-induced oedema in albino rats, with indomethacin as the standard drug. The synthesized compounds exhibited a reduction in oedema formation ranging from 72.3% to 89.3%, surpassing the inhibition observed with indomethacin (46%). Additionally, the compounds were evaluated for their anticancer activity against the MCF-7 breast cancer cell line at a dose of 100µg/ml. Compounds 2f and 2j demonstrated mild anticancer activity with 61% and 68% inhibition, respectively, compared to doxorubicin. Furthermore, molecular docking studies were conducted using the Molego virtual docker program, which revealed that all prepared compounds exhibited high docking scores against both cox-1 and cox-2. The docking scores and binding energy correlated well with the pharmacological results. Lastly, the drug likeness and bioactivity of the compounds were predicted using Molinspiration software, indicating that all new compounds possess favorable drug likeness and bioactivity scores
Synthesis of (1-(2-((5-(4-Substitutedphenyl) Furan/Thiophen-2-Yl) Methylene) Hydrazineyl)-3-(4-Hydroxyphenyl)-1-Oxopropan-2-Yl)-4-(1H-Indol-3-Yl) Butanamide and It’s Pharmacological Studies
No full textA series of (1-(2-((5-(4-substitutedphenyl) furan/thiophen-2-yl) methylene) hydrazineyl)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-4-(1H-indol-3-yl) butanamide is synthesised and screened for antinflammatory activity by using Dexamethasone as a standard drug. Among the Screened derivatives bromine substituted and methyl substituted derivatives showed higher activity than other derivatives
