224 research outputs found
Pari songs
No full textIncludes four prophet songs, fishing songs and chant to wind. Provided to Ian Maddocks by New Zealand author James McNeish
Sputnik diner
No full textFrom an award-winning writer reminiscent of Richard Russo and Russell Banks: get ready for a heady and heartbreaking stay in Nanticoke, home of the Sputnik Diner. Travelling on Highway 3, along the upper lip of Lake Erie and through a moustache of tobacco fields and sky, we arrive in Nanticoke, Ontario. At the heart of the town is the Sputnik Diner, a smoky grill where the jukebox whirs out an ever-changing soundtrack. Navigating their way through the lies and sexual betrayals are Grace, waitress and self-defeating artist; Buzz, who offers the cook's eye view of the eccentric patrons and staff; and Marcel, the gruff French-Canadian owner who doles out hilarious malapropisms and his own peculiar brand of hospitality. In muscular prose, Maddocks traces the lives of flawed, gutsy, and utterly loveable characters: an immigrant family from Wales, struggling to find their place in the ragged, darkly absurd world of tobacco-belt Ontario; two young brothers who steal the family car and try to come to grips with their father's cancer out on the dinosaur mini-putt course in the pouring rain; and Grace, who seeks out her birth parents only to confront the dizzying epiphanies of that momentous discovery. There are others too, whose stalled dreams, gritty hopes and humour spark through the Sputnik Diner universe. --From publisher description.short stor
Bairdiidae Sars 1888
No full textFamily BAIRDIIDAE Sars, 1888 1888 Family Bairdiidae Sars: 288. Nomenclatural Remarks. In an influential review of crustacean classification (Martin & Davis 2001), the author and date of Family Bairdiidae were incorrectly given as “Sars, 1865.” This error has found its way into recent papers and the online World Ostracoda Database (Brand„o et al. 2018). The issue for 1865 actually appeared in 1866 (Kempf 1988, p. 309). In that paper, Sars did name three other families (Conchoeciidae, Polycopidae and Cytherellidae), but he classified the Genus Bairdia in the Family Cypridae Baird, 1845 (Sars 1866, p. 19). The spelling of “ Cypridae ” was validly emended to “ Cyprididae ” by Baird (1850, p. 139; see also Swain 1961, p. Q211; Howe 1955, p. 14; 1962, p. 68). The issue date of Sars’ paper on “ Ostracoda Mediterranea ” was verified as 1888 by Howe (1955, p. 314; 1962, p. 338) during preparation of the Ostracoda volume of the Treatise on Invertebrate Paleontology. The Kraus reprint edition (published in 1969 by Nendeln/ Liechtenstein) states the place and date of publication as “Kristiania 1888.” See also Sylvester-Bradley (1961, p. Q201, Q417), Maddocks (1969, 1995), Maddocks & Iliffe (1986), Maddocks & Wouters (1990), and Brand„o (2008). The date has been erroneously cited as 1887 by Morkhoven (1963, p. 467), Kempf (1988, p. 309), Hartmann (1989, p. 1006), and many others.Published as part of Maddocks, Rosalie F., 2021, Taxonomic applications of the esophageal flapper valve in the Genus Neonesidea (Bairdioidea, Podocopida, Ostracoda), including descriptions of new and poorly known species from the Caribbean and Gulf of Mexico, pp. 451-492 in Zootaxa 4903 (4) on page 454, DOI: 10.11646/zootaxa.4903.4.1, http://zenodo.org/record/443122
From Calbacor: an illustrated lecture
No full textAn excerpt from the book Cabalcor: An Extracted History by Sun Belt is presented. The book was based on songs from Sun Belt's debut album Cabalcor (OffSeason Records).Zine revie
Synthesis, characterization, and efficacy of antimicrobial chlorhexidine hexametaphosphate nanoparticles for applications in biomedical materials and consumer products
No full textMichele E Barbour,1 Sarah E Maddocks,2 Natalie J Wood,1,3 Andrew M Collins3 1Oral Nanoscience, School of Oral and Dental Sciences, University of Bristol, Bristol, UK; 2Cardiff School of Health Sciences, Cardiff Metropolitan University, Cardiff, UK; 3Bristol Centre for Functional Nanomaterials, University of Bristol, Bristol, UK Abstract: Chlorhexidine (CHX) is an antimicrobial agent that is efficacious against gram-negative and -positive bacteria and yeasts. Its mechanism of action is based on cell membrane disruption and, as such, it does not promote the development of bacterial resistance, which is associated with the widespread use of antibiotics. In this manuscript, we report the development of novel antimicrobial nanoparticles (NPs) based on a hexametaphosphate salt of CHX. These are synthesized by instantaneous reaction between equimolar aqueous solutions of CHX digluconate and sodium hexametaphosphate, under room temperature and pressure. The reaction results in a stable colloid composed of highly negatively charged NPs (−50 mV), of size 20-160 nm. The NPs adhere rapidly to specimens of glass, titanium, and an elastomeric wound dressing, in a dose-dependent manner. The functionalized materials exhibit a gradual leaching of soluble CHX over a period of at least 50 days. The NP colloid is efficacious against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa in both planktonic and biofilm conditions. These NPs may find application in a range of biomedical and consumer materials. Keywords: MRSA, biomaterials, chlorhexidine, drug delivery, slow releas
News & Issues piece on the number of tourists visiting Maine, which has increa
No full textNews & Issues piece on the number of tourists visiting Maine, which has increased significantly this year, according to officials from the Maine Turnpike Authority, Acadia National Park and the Maine Office of Tourism. Suzanne Maddocks of the Convention and Visitors Bureau of Greater Portland offers Portland\u27s growing recognition in national media as one explanation
Functionalization of ethylene vinyl acetate with antimicrobial chlorhexidine hexametaphosphate nanoparticles
No full textNatalie J Wood,1–3 Sarah E Maddocks,4 Helena J Grady,1,2 Andrew M Collins,2 Michele E Barbour11Oral Nanoscience, School of Oral and Dental Sciences, 2Bristol Centre for Functional Nanomaterials, 3Centre for Organised Matter Chemistry, School of Chemistry, University of Bristol, UK; 4School of Health Sciences, Cardiff Metropolitan University, UKAbstract: Ethylene vinyl acetate (EVA) is in widespread use as a polymeric biomaterial with diverse applications such as intravitreal devices, catheters, artificial organs, and mouthguards. Many biomaterials are inherently prone to bacterial colonization, as the human body is host to a vast array of microbes. This can lead to infection at the biomaterial’s site of implantation or application. In this study, EVA was coated with chlorhexidine (CHX) hexametaphosphate (HMP) nanoparticles (NPs) precipitated using two different reagent concentrations: CHX-HMP-5 (5 mM CHX and HMP) and CHX-HMP-0.5 (0.5 mM CHX and HMP). Data gathered using dynamic light scattering, transmission electron microscopy, and atomic force microscopy indicated that the NPs were polydisperse, ~40–80 nm in diameter, and aggregated in solution to form clusters of ~140–200 nm and some much larger aggregates of 4–5 µM. CHX-HMP-5 formed large deposits on the polymer surface discernible using scanning electron microscopy, whereas CHX-HMP-0.5 did not. Soluble CHX was released by CHX-HMP-5 NP-coated surfaces over the experimental period of 56 days. CHX-HMP-5 NPs prevented growth of methicillin-resistant Staphylococcus aureus when applied to the polymer surfaces, and also inhibited or prevented growth of Pseudomonas aeruginosa with greater efficacy when the NP suspension was not rinsed from the polymer surface, providing a greater NP coverage. This approach may provide a useful means to treat medical devices fabricated from EVA to render them resistant to colonization by pathogenic microorganisms.Keywords: EVA, biomaterial, polyme
Novel targets of antimicrobial therapies
No full textDuring the golden age of antibiotic discovery, from the 1930s through the 1960s, methods of antibiotic identification relied solely on scientific observation, and while chemical analogues such as amoxicillin, derived from penicillin, continued to be developed, they retained the same mechanisms of action and hence the same bacterial targets. Moreover, there are finite modifications that can ultimately be made to “old” classes of antibiotics. Consequently, only two new classes of antibiotics have been discovered in the past 40 years, and both entered the market early in the new millennium. The advent of the genomics revolution offered a new hope for the discovery of novel antimicrobial targets. Genomic strategies were utilized to identify potential antibacterial targets, namely those that, if inhibited, resulted in the death of the bacterium. Such targets were to be present in pathogenic strains of bacteria and absent from the human host; they could include metabolic pathways, receptor ligands, and virulence traits, to name a few. Despite the abundance of targets identified using this strategy, no new antibiotics have reached the marketplace as a result of the genomics approach. However, new antimicrobials with novel targets continue to be identified and contribute to the ongoing struggle against antimicrobial resistance that threatens to return humankind to a situation comparable to the preantibiotic era
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