204 research outputs found
sj-docx-1-msj-10.1177_13524585221148094 – Supplemental material for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus
No full textSupplemental material, sj-docx-1-msj-10.1177_13524585221148094 for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus by Priyanka Iyer, Kate Wiles, Azza Ismail, Surabhi Nanda, Katy Murray, Stella Hughes, Helen L Ford, Owen R Pearson, Sarah White, Nicola Bonham, Natasha Hoyle, James Witts, Rod Middleton, Peter A Brex, David Rog and Ruth Dobson in Multiple Sclerosis Journal</p
sj-docx-3-msj-10.1177_13524585221148094 – Supplemental material for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus
No full textSupplemental material, sj-docx-3-msj-10.1177_13524585221148094 for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus by Priyanka Iyer, Kate Wiles, Azza Ismail, Surabhi Nanda, Katy Murray, Stella Hughes, Helen L Ford, Owen R Pearson, Sarah White, Nicola Bonham, Natasha Hoyle, James Witts, Rod Middleton, Peter A Brex, David Rog and Ruth Dobson in Multiple Sclerosis Journal</p
sj-docx-2-msj-10.1177_13524585221148094 – Supplemental material for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus
No full textSupplemental material, sj-docx-2-msj-10.1177_13524585221148094 for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus by Priyanka Iyer, Kate Wiles, Azza Ismail, Surabhi Nanda, Katy Murray, Stella Hughes, Helen L Ford, Owen R Pearson, Sarah White, Nicola Bonham, Natasha Hoyle, James Witts, Rod Middleton, Peter A Brex, David Rog and Ruth Dobson in Multiple Sclerosis Journal</p
sj-docx-4-msj-10.1177_13524585221148094 – Supplemental material for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus
No full textSupplemental material, sj-docx-4-msj-10.1177_13524585221148094 for Developing evidence-based guidelines for the safety of symptomatic drugs in multiple sclerosis during pregnancy and breastfeeding: A systematic review and Delphi consensus by Priyanka Iyer, Kate Wiles, Azza Ismail, Surabhi Nanda, Katy Murray, Stella Hughes, Helen L Ford, Owen R Pearson, Sarah White, Nicola Bonham, Natasha Hoyle, James Witts, Rod Middleton, Peter A Brex, David Rog and Ruth Dobson in Multiple Sclerosis Journal</p
SHAPE - A UNIFYING CONCEPT IN DOCUMENT LAYOUT
No full textText objects have traditionally been constrained to be rectangular,
a constraint inherited by modern computer document preparation systems.
However, a variety of tasks in document formatting benefit from a more
general notion of shape. This paper describes such a representation,
suitable for graphic composition at both low and high levels of
document layout. Intermediate in generality and complexity between
rectangles and arbitrary polygons, it comprises separate left and right
margin functions composed piecewise of linear segments. Such shapes
can be compared, conbined, modified and generated using simple, economical
algorithms. This notion of shape appears to provide the correct level
of abstraction for elegant solutions to several knotty problems in
existing systems. Software methods making use of shape have been
implemented in JOT [Bonham 1985], an interactive documentation system
under development as part of the University of Calgary JADE project
[Witten et al 1983].We are currently acquiring citations for the work deposited into this collection. We recognize the distribution rights of this item may have been assigned to another entity, other than the author(s) of the work.If you can provide the citation for this work or you think you own the distribution rights to this work please contact the Institutional Repository Administrator at [email protected]
Katamari Kart: A serious and hilarious sub/urban game for more serendipitous, playful and friendly public art
No full textThe article presents the sub/urban game-method Katamari Kart, where people roam industrial and suburban areas collecting waste materials and progressively building a large and mobile public sculpture. This game-method departs from established concepts and practice in neighbourhood improvement as it tries to evade capital expenditure and embraces uncertainty and friction in bringing together various stakeholders, does not aim to look stylish or even be useful, decelerates daily life, promotes self-sufficiency in cultural life, and creates long-term wellbeing through play. That is, it is a degrowth approach to neighbourhood improvement. Rumen Rachev positions the Katamari Kart game-method as an expression of the ‘Kiwi way’ and discusses the role it can play in making our future neighbourhoods more serendipitous, playful and friendly, and a ref lection of the diverse people and things that reside there – all without capital expenditure or the support of the authorities. Finally, Alex Bonham, author of the book Play and the City: How to Create Places and Spaces to Help Us Thrive, discusses the Katamari Kart game-method in the context of adult play, our settler history, keeping up appearances, the Be a Tidy Kiwi campaign, play and wellbeing, and conflicting responses to frugality
First Synthesis of an Aziridinyl Fused Pyrrolo[1,2-a]benzimidazole and Cytotoxicity Evaluation of Various Imidazobenzimidazolequinones Towards Human Normal and Cancer Cell Lines
No full textChapter 1 provides a review of aziridine containing anti-tumour agents and
some key syntheses of the aziridinomitosene skeleton. A novel protocol for
aziridine ring fusion is described leading to the preparation of the first aziridinyl
fused pyrrolo[1,2-a]benzimidazole. This diazole analogue of aziridinomitosene
was formed via selective lithiation of the aziridine leading to an anionic aromatic
ipso-substitution onto the benzimidazole-2-position. A non-fused aziridine
containing benzimidazole is also prepared for cytotoxicity comparisons. Both
novel aziridine compounds are evaluated towards a human normal skin fibroblast
cell line (GM00637) and two breast cancer cell lines (MCF-7) and (HCC1937).
The latter is breast cancer tumour suppressor gene deficient (BRCA1 deficient),
and showed hypersensitivity to mitomycin C (MMC). BRCA1 is reported to play
a key role in the repair of DNA damage. Both aziridine benzimidazole
compounds are more cytotoxic towards the breast cancer cell lines than the
normal cell line. The evidence provided indicates that different pathways mediate
cellular response to benzimidazole containing-aziridine compounds compared to
MMC.
Chapter 2 begins with an introduction to the enzyme-directed approach to
chemotherapy, and a review of polycyclic quinones. A series of dialicyclic ring
fused imidazo[5,4-f]benzimidazolequinones were evaluated using the MTT assay
towards two human cancer cell lines; cervical (HeLa) and prostate (DU145) and
a normal cell line (GM00637). Dipyrido[5,4-f]imidazobenzimidazolequinone is
found to possess similar toxicity to its [4,5-f] isomer, while an oxygen atom in
the alicyclic fused ring ([1,4]oxazino) is found to dramatically increase toxicity
towards all three cell lines. The toxicity of pyrido-fused compounds is found to
be less than the N-butyl analogues, and increasing the alicyclic ring size from
five to seven membered reduces activity. Iminoquinone is found to be ~12 times
more toxic towards prostate cancer than towards the normal cell line. The
iminoquinone shows a moderate to strong correlation towards cell lines
expressing high levels of NQO1 activity, confirmed by further testing at the
National Cancer Institute (NCI-60 program).
Chapter 3 describes in detail the experimental procedures for Chapters 1 and 2
The Greening of Arabica: An Investigation into Business Environmental Supply Chain Management, Using Cafedirect as a Case Study
No full textImperial Users onl
Dynamics of tropical climate and high-latitude teleconnections during the Pliocene
No full textThe El Nino-Southern Oscillation (EN SO) in the tropical Pacific, is the most dominant mode of inter-annual variability in the climate system, with significant global impacts. It is therefore vital to understand how this phenomenon may respond to long-term changes in global mean temperature. One way to test this is to examine past warm climates such as the mid-Pliocene Warm Period (mPWP; ea. 3.26 to 3.0 Ma), when global mean temperature and atmospheric CO2 were higher than today, at levels similar to predictions for the late 21 st Century. MPWP proxy data suggest that the tropical Pacific was characterised by a reduced sea surface temperature (SST) gradient and permanent El Nino-like condition, which has implications for how ENSO may respond to anthropogenic forcing of the climate. ENSO dynamics during the mPWP were assessed through a series of model experiments using the Hadley Centre Coupled Climate Model. Tropical Pacific SST in the mPWP Control experiment was significantly warmer than the pre-industrial control with a low east-to-west gradient. Initial results showed that ENSO variability continued despite an El Nino-like mean state, with increased frequency and amplitude although fewer extreme events. The propagation of SST anomalies shifted towards the T-mode, similar to the pattern seen in the last 30 years of the instrumental record. Sensitivity experiments showed that the strongest contributors to changes in ENSO were lower orography over North and South America and higher CO2. In the extratropics, the presence of 'modern' teleconnection patterns in the mPWP simulation can be attributed to changes in boundary conditions, with large differences between modern and mPWP teleconnections. Finally, extending the control simulations by ~1,000 years, showed that these changes remain in the mid- Pliocene simulation, with reduced centennial variability compared to the pre-industrial control.EThOS - Electronic Theses Online ServiceGBUnited Kingdo
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