186,342 research outputs found
A new system for assessing visual disability using a digital visor
No full textBackground: Considering the lack of universally accepted visual requirements for driving and for defining various grades of visual disability, the aim of this study is to propose a new method that provides a numerical score resulting from a combined assessment of the visual field and visual acuity loss obtained using a digital technology visor. Methods: This study presents a new system for calculating the percentage of visual disability by combining binocular visual acuity and binocular visual field assessments. A new Global Vision Evaluation System digital technology visor uses standardized, reproducible criteria to produce well-defined, numerically expressed test results. Through a specific algorithm, the device produces a numerical value expressing the percentage of visual disability. Results: Eighty-six subjects with various types of visual impairment underwent visual acuity and visual field test examinations carried out employing both traditional methods and the new digital visor. The two methods provided homogeneously similar results regarding the positioning of the subjects on the visual disability scale. Conclusions: The new digital visor seems to be a valid method to ensure that visual disability assessments are more homogeneous and reliable, and that, consequently, the resources available for this purpose are more fairly distributed
Human embryonic stem cells recover in vivo acute lung inflammation bleomycin-induced
No full textIdiopathic pulmonary fibrosis (IPF) is characterized by alveolar epithelial cell injury, type II cell activation, apoptosis and bronchiolar epithelial cell proliferation, accumulation of extracellular matrix and fibroblasts. No current animal model recapitulates all of these cardinal manifestation of the human disease. However, bleomycin instillation in mice lung by intranasal way (ITN) represents the best experimental model of pulmonary fibrosis in which alveolar pneumocytes type II (ATII) are usually depleted. The aim of this study was to test the possibility to recover acute lung fibrosis after transplantation of human embryonic type II derived-pneumocytes in a murine model of bleomycin-induced damage. Our results indicate the striking "clinical" beneficial effect of differentiated HUES-3 cells into ATII in terms of lung function, weight loss and mortality in injured mice, suggesting this stem cell therapy as a promising, systemic and specific treatment of human pulmonary fibrosis
Trattamento in urgenza delle lesioni traumatiche del ginocchio. Lesioni acute associate vascolo-nervose.
No full textThis report evaluates resulta in the management of 51 cases of traumatic popliteal vessels injuries associated to traumatic lesions of the knee. In 40 cases the arterial injury was diagnosed both clinically and by Doppler exam; in 11 cases arteriography was performed. Bone synthesis was first performed in 11 cases with Hoffmann's external fixation device, in 7 cases with "a minima" synthesis and in further 7 cases with A.O. tecnique. Forty-eight of the 51 arterial recontructions required interposition by-pass graft, 40 of wich were autogenous saphenous veins. Thirty-four patients had associated venous injuries and 22 venous injuries were repaired. In 18 patients the ischemic time was shortened by the use of temporary silastic shunt for restoration of arterial flow. In 12 cases fasciotomy there was functinal loss: particularly when nerves were injured or articular bone fractures were present
Possibilità conservative e/o chirurgiche nel trattamento d’urgenza delle emorragie da varici esofagee.
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