6,042 research outputs found
sj-docx-2-ajr-10.1177_19458924221096913 - Supplemental material for Magnetic Resonance Imaging as a Diagnostic and Research Tool in Patients with Olfactory Dysfunction: A Systematic Review
No full textSupplemental material, sj-docx-2-ajr-10.1177_19458924221096913 for Magnetic Resonance Imaging as a Diagnostic and Research Tool in Patients with Olfactory Dysfunction: A Systematic Review by Nanki Hura, Julie S. Yi, Sandra Y. Lin and Christopher R. Roxbury in American Journal of Rhinology & Allergy</p
sj-docx-3-ajr-10.1177_19458924221096913 - Supplemental material for Magnetic Resonance Imaging as a Diagnostic and Research Tool in Patients with Olfactory Dysfunction: A Systematic Review
No full textSupplemental material, sj-docx-3-ajr-10.1177_19458924221096913 for Magnetic Resonance Imaging as a Diagnostic and Research Tool in Patients with Olfactory Dysfunction: A Systematic Review by Nanki Hura, Julie S. Yi, Sandra Y. Lin and Christopher R. Roxbury in American Journal of Rhinology & Allergy</p
sj-docx-1-ajr-10.1177_19458924221096913 - Supplemental material for Magnetic Resonance Imaging as a Diagnostic and Research Tool in Patients with Olfactory Dysfunction: A Systematic Review
No full textSupplemental material, sj-docx-1-ajr-10.1177_19458924221096913 for Magnetic Resonance Imaging as a Diagnostic and Research Tool in Patients with Olfactory Dysfunction: A Systematic Review by Nanki Hura, Julie S. Yi, Sandra Y. Lin and Christopher R. Roxbury in American Journal of Rhinology & Allergy</p
Lowest electronic states of neutral and ionic LiN
No full textWe have investigated the potential energy curves (PECs) of the LiN heteronuclear diatomic molecule, including its ionic species LiN+ and LiN−, using explicitly correlated multi-reference configuration interaction (MRCI-F12) calculations in conjunction with the correlation consistent quintuple- basis set. The effect of core–valence correlation, scalar relativistic effects, and the size of the basis sets has been investigated. A comprehensive set of spectroscopic constants determined based on the above-mentioned calculations are also reported for the lowest electronic states and all systems, including dissociation energies, harmonic and anharmonic vibrational frequencies, and rotational constants. Additional parameters, such as the dipole moments, equilibrium spin-orbit constants, excitation energies, and rovibrational energy levels, are also documented. We found that the three triplet states of LiN, namely, X 3∑−, A 3Π, and 2 3∑−, exhibit substantial potential wells in the PEC diagrams, while the quintet states are repulsive in nature. The ground state of the anion also shows a deep potential well in the vicinity of its equilibrium geometry. In contrast, the ground and excited states of the cation are very loosely bound. Charge transfer properties of each of these states are also analyzed to obtain an in-depth understanding of the interatomic interactions. We found that the core–valence correlation has a substantial effect on the calculated spectroscopic constants.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Atmospheric Remote Sensin
Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages
No full textGenetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)-induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy. To determine whether vascular endothelial growth factor A (VEGF-A) produced by tumor-associated macrophages regulated the onset of the angiogenic switch, a genetic approach was used to restore expression of VEGF-A into tumors at the benign stages. This stimulated formation of a high-density vessel network and in macrophage-depleted mice, was followed by accelerated tumor progression. The expression of VEGF-A led to a massive infiltration into the tumor of leukocytes that were mostly macrophages. This study suggests that macrophage-produced VEGF regulates malignant progression through stimulating tumor angiogenesis, leukocytic infiltration and tumor cell invasion
Propuestas de mejora de los factores relevantes del financiamiento de las micro y pequeñas empresas nacionales: caso empresa Lin Yin Construcciones y Proyectos E.I.R.L. –Tumbes, 2020
No full textEl presente trabajo de investigación tuvo como objetivo general: Identificar las oportunidades del financiamiento que mejoren las posibilidades de las micro y pequeñas empresas nacionales y de la empresa Lin Yin Construcciones y Proyectos E.I.R.L. – Tumbes, 2020. Para la elaboración de este informe se utilizó la metodología cuantitativa y diseño no experimental, descriptivo, bibliográfico y de caso, aplicándose las técnicas de revisión bibliográfica y entrevista, también se utilizó los instrumentos de fichas bibliográficas y un cuestionario de preguntas cerradas; obteniéndose las siguientes conclusiones: Respecto al objetivo específico 01: Según los autores de los antecedentes, la mayoría de las micro y pequeñas empresas tiene la oportunidad de recurrir al financiamiento de terceros. Respecto al objetivo 02, Respecto al cuestionario realizado a la Gerente de la empresa, permitió Identificar oportunidades del financiamiento que mejoren las posibilidades de las micro y pequeñas empresas nacionales y de la empresa Lin Yin Construcciones y Proyectos E.I.R.L., con los resultados obtenidos, podemos afirmar que utilizo el financiamiento por parte de terceros, de la Caja Municipal de Sullana. Respecto al Objetivo específico 03: De acuerdo a los resultados obtenidos del objetivo específico 1 y objetivo específico 2, los factores relevantes se relacionan ambas en donde se afirman que obtienen financiamiento. Conclusión general: haciendo un análisis se confirma que las micro y pequeñas empresas, incluida la empresa Lin Yin Construcciones y Proyectos E.I.R.L. Cuentan con oportunidades de financiamiento tanto interno como externo, con tasas de interés establecidas, plazos pactados.Tesi
Thyroid Hormone and P- Glycoprotein in tumor cells.
No full textP-glycoprotein (P-gp; multidrug resistance pump 1, MDR1; ABCB1) is a plasma membrane efflux pump that when activated in
cancer cells exports chemotherapeutic agents. Transcription of the P-gp gene (MDR1) and activity of the P-gp protein are known to
be affected by thyroid hormone. A cell surface receptor for thyroid hormone on integrin v3 also binds tetraiodothyroacetic
acid (tetrac), a derivative of L-thyroxine (T4) that blocks nongenomic actions of T4 and of 3,5,3-triiodo-L-thyronine (T3) at
v3. Covalently bound to a nanoparticle, tetrac as nanotetrac acts at the integrin to increase intracellular residence time of
chemotherapeutic agents such as doxorubicin and etoposide that are substrates of P-gp. This action chemosensitizes cancer cells.
In this review, we examine possible molecular mechanisms for the inhibitory effect of nanotetrac on P-gp activity.Mechanisms for
consideration include cancer cell acidification via action of tetrac/nanotetrac on the Na+/H+ exchanger (NHE1) and hormone
analogue effects on calmodulin-dependent processes and on interactions of P-gp with epidermal growth factor (EGF) and
osteopontin (OPN), apparently via v3. Intracellular acidification and decreasedH+ efflux induced by tetrac/nanotetrac viaNHE1
is the most attractive explanation for the actions on P-gp and consequent increase in cancer cell retention of chemotherapeutic
agent-ligands of MDR1 protein
L-Thyroxine vs 3,5,3'-Triodo-L-Thyronine and cell proliferation: Activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
No full textTriiodo-L-thyronine (T(3)), but not L-thyroxine (T(4)), activated Src kinase and, downstream, phosphatidylinositol 3-kinase (PI3-kinase) by means of an alpha(v)beta(3) integrin receptor on human glioblastoma U-87 MG cells. Although both T(3) and T(4) stimulated extracellular signal-regulated kinase (ERK) 1/2, activated ERK1/2 did not contribute to T(3)-induced Src kinase or PI3-kinase activation, and an inhibitor of PI3-kinase, LY-294002, did not block activation of ERK1/2 by physiological concentrations of T(3) and T(4). Thus the PI3-kinase, Src kinase, and ERK1/2 signaling cascades are parallel pathways in T(3)-treated U-87 MG cells. T(3) and T(4) both caused proliferation of U-87 MG cells; these effects were blocked by the ERK1/2 inhibitor PD-98059 but not by LY-294002. Small-interfering RNA knockdown of PI3-kinase confirmed that PI3-kinase was not involved in the proliferative action of T(3) on U-87 MG cells. PI3-kinase-dependent actions of T(3) in these cells included shuttling of nuclear thyroid hormone receptor-alpha (TR alpha) from cytoplasm to nucleus and accumulation of hypoxia-inducible factor (HIF)-1 alpha mRNA; LY-294002 inhibited these actions. Results of studies involving alpha(v)beta(3) receptor antagonists tetraiodothyroacetic acid (tetrac) and Arg-Gly-Asp (RGD) peptide, together with mathematical modeling of the kinetics of displacement of radiolabeled T(3) from the integrin by unlabeled T(3) and by unlabeled T(4), are consistent with the presence of two iodothyronine receptor domains on the integrin. A model proposes that one site binds T(3) exclusively, activates PI3-kinase via Src kinase, and stimulates TR alpha trafficking and HIF-1 alpha gene expression. Tetrac and RGD peptide both inhibit T(3) action at this site. The second site binds T(4) and T(3), and, via this receptor, the iodothyronines stimulate ERK1/2-dependent tumor cell proliferation. T(3) action here is inhibited by tetrac alone, but the effect of T(4) is blocked by both tetrac and the RGD peptide
How good are dynamic factor models at forecasting output and inflation? A meta-analytic approach
No full textThis paper surveys existing factor forecast applications for real economic activity and inflation by means of a meta-analysis and contributes to the current debate on the determinants of the forecast performance of large-scale dynamic factor models relative to other models. We find that, on average, factor forecasts are slightly better than other models' forecasts. In particular, factor models tend to outperform small-scale models, whereas they perform slightly worse than alternative methods which are also able to exploit large datasets. Our results further suggest that factor forecasts are better for US than for UK macroeconomic variables, and that they are better for US than for euro-area output; however, there are no significant differences between the relative factor forecast performance for US and euro-area inflation. There is also some evidence that factor models are better suited to predict output at shorter forecast horizons than at longer horizons. These findings all relate to the forecasting environment (which cannot be influenced by the forecasters). Among the variables capturing the forecasting design (which can, by contrast, be influenced by the forecasters), the size of the dataset from which factors are extracted seems to positively affect the relative factor forecast performance. There is some evidence that quarterly data lend themselves better to factor forecasts than monthly data. Rolling forecasts are preferable to recursive forecasts. The factor estimation technique seems to matter as well. Other potential determinants - namely whether forecasters rely on a balanced or an unbalanced panel, whether restrictions implied by the factor structure are imposed in the forecasting equation or not and whether an iterated or a direct multi-step forecast is made - are found to be rather irrelevant. Moreover, we find no evidence that pre-selecting the variables to be included in the panel from which factors are extracted helped to improve factor forecasts in the past. --Factor models,forecasting,meta-analysis
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