294 research outputs found
Congenital erythropoietic porphyria with undescended testis
No full textHereditary porphyrias are a group of metabolic disorders of heme biosynthesis pathway that are characterized by acute neurovisceral symptoms, skin lesions, or both. Congenital erythropoietic porphyria (CEP) is an extremely rare disease with a mutation in the gene that codes for uroporphyrinogen III synthase leading to accumulation of porphyrin in different tissues and marked cutaneous photosensitivity. We report a case of CEP with infancy onset blistering, photosensitivity, red colored urine, and teeth along with scarring. Examination revealed an undescended testis of the left side. Mutation analysis revealed mutation in the uroporphyrinogen III synthase gene (UROS) resulting in c. 56 A > G (Tyr19Cys). The presence of undescended testis with a rare mutation in a case of CEP which itself is an extremely rare condition make the case interesting
Prosthetic rehabilitation of edentulous patient with limited oral access: A clinical report
No full textMicrostomia may result from surgical treatment of orofacial neoplasms, cleft lips, maxillofacial trauma, burns, radiotherapy or scleroderma. A maximal oral opening that is smaller than the size of a complete denture can make prosthetic treatment challenging. This clinical report presents the prosthodontic management of a total edentulous patient with microstomia. Sectional mandibular and maxillary trays and foldable mandibular and maxillary denture were fabricated for the total edentulous patient
An alternative treatment of occlusal wear: Cast metal occlusal surface
No full textAcrylic resin denture teeth often exhibit rapid occlusal wear, which may lead to decrease in the chewing efficiency, loss of vertical dimension of occlusion, denture instability, temporomandibular joint disturbances, etc. There are various treatment options available like, use of highly cross linked acrylic teeth, amalgam or metal inserts on occlusal surface, use of composite, gold or metal occlusal surface, etc. Several articles have described methods to construct gold and metal occlusal surfaces, however, these methods are time-consuming, expensive and requires many cumbersome steps. These methods also requires the patient to be without the prosthesis for the time during which the laboratory procedures are performed. This article presents a quick, simple and relatively inexpensive procedure for construction of metal occlusal surfaces on complete dentures
Hepatitis B, interferon, and acne fulminans in a young girl
No full textAcne fulminans (AF) is a very rare severe form of acne seen in young males, characterized by a sudden and explosive onset of hemorrhagic pustules and ulceration on the trunk, systemic features in the form of fever, polyarthropathy, malaise, erythema nodosum and painful osteolytic bone involvement with leukocytosis, and an elevated erythrocyte sedimentation rate. Conventional treatment of AF includes corticosteroids or immunosuppressive agents for the initial phase followed by isotretinoin. Active hepatitis B infection with a high viral load precludes the administration of any immunosuppressive drugs. We present the case of an 18-year-old girl with a history of occasional acne who presented with AF of sudden onset following administration of interferon-alpha-2a for her recently detected hepatitis B infection. Management of hepatitis B was withheld in view of her general condition. The patient was managed with low dose isotretinoin with subsidence of lesions. AF in a young female precipitated by interferon and its management with isotretinoin in the presence of active hepatitis B infection make the case unique
Simulation-based POLCA integrated QRM approach for smart manufacturing
No full textDigitalisation and Industry 4.0 have enabled real-time interaction of customers and suppliers with manufacturing systems. However, this requires a high level of reactivity in the value chain to sustain in a competitive economy. As a result, Quick Response Manufacturing (QRM) in dynamic conditions such as wide product variety, change in demand, volatile market conditions, uncertainty in supply, and machine failures is critical in capturing the benefits of digitalisation in industries. To empower QRM, Paired-cell Overlapping Loops of Cards with Authorization (POLCA) is suitable for a manufacturing environment with a wide variety and highly dynamic conditions. The combination of QRM and POLCA provides a significant competitive advantage through their quick response to dynamic conditions. Such a combination is not reported in the literature. Accordingly, this paper proposes a simulation-based POLCA integrated with the QRM approach for smart manufacturing. The offered approach evaluates a dynamic sequence of jobs at each machine to meet the due date and at the same time control the material flow to improve system performance. The approach is illustrated with the help of a complex manufacturing scenario. A simulation-based technique is used to evaluate the system performance. Further, the performance of the approach under dynamic conditions is analysed. Results show that improved system performance can be achieved by considering QRM and POLCA in dynamic conditions.</p
COMPARATIVE ANALYSIS OF AODV AND DSDV USING MACHINE LEARNING APPROACH IN MANET
No full textMobile Ad-Hoc networks possess a dynamic structure which is characterized by the absence of central administrator. Due to such dynamic network, the possibilities of acquisition of optimal path diminish to a great extent and hence the durability of the optimal transmission of data packet becomes severe. Each and every node in MANET is battery powered up and mobile in nature, hence
mobility becomes the prime reason of energy exhaustion in such network. The main objective of presented paper is to attain the most reliable path with least mobility for successful transmission of data packets. The algorithm used for attainment of optimal path is knowledge based learning algorithm which is implied over two routing protocols; AODV (Ad-Hoc On Demand Distance Vector Routing) and DSDV (Destination Sequence Distance Vector Routing). The performance evaluation is done by means of Relay Number which is inversely proportional to the mobility of node. AODV and DSDV are further employed over network systems with varying number of nodes, i.e., 12 and 24 nodes network system. The performance comparison is made on the basis of two performance parameters such as throughput and PDR (Packet Delivery Ratio). A proposition is made that analysis of PDR and throughput in knowledge based learning algorithm is better in comparison with other traditional techniques like Destination Sequence Distance Vector (DSDV). The simulation is performed over NS-2 network simulator, which enables the implementation of wired and wireless simulation
Dynamics of a delayed prey-predator model using modified Holling Tanner functional response with migration
No full textPhytochemicals from Plant Foods as Potential Source of Antiviral Agents: An Overview
No full textTo date, the leading causes of mortality and morbidity worldwide include viral infections, such as Ebola, influenza virus, acquired immunodeficiency syndrome (AIDS), severe acute respiratory syndrome (SARS) and recently COVID-19 disease, caused by the SARS-CoV-2 virus. Currently, we can count on a narrow range of antiviral drugs, especially older generation ones like ribavirin and interferon which are effective against viruses in vitro but can often be ineffective in patients. In addition to these, we have antiviral agents for the treatment of herpes virus, influenza virus, HIV and hepatitis virus. Recently, drugs used in the past especially against ebolavirus, such as remdesivir and favipiravir, have been considered for the treatment of COVID-19 disease. However, even if these drugs represent important tools against viral diseases, they are certainly not sufficient to defend us from the multitude of viruses present in the environment. This represents a huge problem, especially considering the unprecedented global threat due to the advancement of COVID-19, which represents a potential risk to the health and life of millions of people. The demand, therefore, for new and effective antiviral drugs is very high. This review focuses on three fundamental points: (1) presents the main threats to human health, reviewing the most widespread viral diseases in the world, thus describing the scenario caused by the disease in question each time and evaluating the specific therapeutic remedies currently available. (2) It comprehensively describes main phytochemical classes, in particular from plant foods, with proven antiviral activities, the viruses potentially treated with the described phytochemicals. (3) Consideration of the various applications of drug delivery systems in order to improve the bioavailability of these compounds or extracts. A PRISMA flow diagram was used for the inclusion of the works. Taking into consideration the recent dramatic events caused by COVID-19 pandemic, the cry of alarm that denounces critical need for new antiviral drugs is extremely strong. For these reasons, a continuous systematic exploration of plant foods and their phytochemicals is necessary for the development of new antiviral agents capable of saving lives and improving their well-being
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