91,424 research outputs found
Letter from Seth Low
No full textWhittier House scrapbooks document Whittier House programs, events, and anniversary celebrations through newspaper clippings, lecture fliers, newsletters, event programs, and ticket stubs. Newspaper clippings are primarily from the Jersey Journal. There is also Whittier House fundraising materials, including pamphlets, appeal letters, brochures, and postcards. The Whittier House Social Settlement, the first settlement house in New Jersey, was established in Jersey City, N.J. (Hudson County) in 1894. Founded by Cornelia Foster Bradford, who would remain with the organization as headworker until 1926, Whittier House was based on the settlement house, Toynbee Hall, in England. Whittier House provided various recreational and educational programs, along with much needed social services, for the immigrant populations of Jersey City. Many of these successful services were used as models for large-scale social reform movements through the state. In 1935, the Whittier House was taken over by the Boys' Club of Jersey City
An investigation into the genetic basis of primary angle-closure glaucoma
No full textPrimary angle-closure glaucoma (PACG) is a common cause of irreversible blindness worldwide but the epidemiology varies significantly between races. This thesis describes the clinical and genetic examination of families with primary angle-closure suspect (PACS) and more advanced disease. Participants were mainly of European origin, from 101 families. Parametric, non-parametric and quantitative trait linkage analyses, a pilot case-control study and targeted gene screening were performed. In the largest PACG family recruited, two promising regions on chromosomes 10 and 13 were identified. Phenotype-genotype correlation highlighted plateau iris to be the most prominent feature in affected individuals, although shorter axial biometry and hyperopic refractive error were also observed. Quantitative trait linkage applied to a number of traits measured by anterior segment optical coherence tomography provided support for the chromosomes 10 and 13 loci. Maximum iris thickness and adjusted axial length at the chromosome 10 region showed LOD score of 1.3 and 1.5 respectively. Adjusted anterior chamber depth and lens vault on chromosome 13 showed LOD scores of 1.7. As the linkage results were suggestive but not conclusive, a pilot case-control study, followed by participation in an international consortium-led genome wide association study (GWAS) was performed. Three single nucleotide polymorphisms, rs1015213, rs3753841 and rs11024102, were found to be associated with cases of acute angle closure (AAC) and PACG. The loci for our family based analyses and the GWAS did not overlap. In 13 families, PAC was found in probands but further clinical and genetic examination of family members identified atypical features. Angle-closure was often observed as part of a more complex ocular phenotype that led to syndromic diagnoses of Noonan, Marfan, Weill-Marchesani, Ehlers-Danlos and Bestrophinopathies. In conclusion, PACG is a multifactorial disease. Phenotypic predisposition such as plateau iris has a small number of genetic contributors, but advanced disease has further contributions from common SNPs
Use of Fourier-Transform Infrared Spectroscopy for the Diagnosis of Failure of Transfer of Passive Immunity and Measurement of Immunoglobulin Concentrations in Horses
No full textBackground: The economic, accurate, and rapid screening of foals for failure of transfer of passive immunity (FPT) is essential to ensure timely intervention. Hypothesis: Infrared (IR) spectroscopy of foal sera and pattern recognition may be used to diagnose FPT and quantify serum IgG. Samples: Sera from 194 foals (24–72 hours) with serum immunoglobulin G (IgG) concentrations determined previously by radial immunodiffusion assay (RID) were used. Methods: IR spectra were recorded for the serum samples, and the data were randomly divided into training and independent test sets, each containing both FPT-positive (IgG <400 mg/dL) and non-FPT samples. A genetic optimal region selection algorithm and linear discriminant analysis were used to partition the training spectra, and the resulting classifier was then validated by comparing the IR-predicted FPT status for each of the test samples to that provided by the RID IgG assay. A quantitative IR-based assay for IgG was developed using partial least squares (PLS) and validated by testing its ability to predict IgG concentrations. Results: Specificity, sensitivity, and accuracy for the combined data were 92.5, 96.8, and 95.9%, respectively. Corresponding positive (88.1%) and negative predictive (98.0%) values determined a success rate of 95–97% as compared to RID-based IgG concentrations. The IR-based quantitative assay yielded correlation coefficients for IR spectroscopy versus RID-based IgG concentrations of 0.90 and 0.86 for the training and test sets, respectively. Conclusions and Clinical Importance: The overall performance of the IR-based test was similar to that of the colorimetric assay and was superior and more economic than other available tests.Christopher B. Riley, J.T. McClure, Sarah Low-Ying, and R. Anthony Sha
jDHBenelux Author Template
No full textThis repository contains the latest official GitHub hosted versions of the LaTeX template that authors are required to use when they finalize their contribtions to the DH Benelux Journal. The repository synchronises with the corresponding easy-to-use and well-documented Overleaf Template that provides authors with a low threshold environment for writing LaTeX – but can be used with any LaTeX compiler.
About this Release: Apart from some minor changes to the .cls, v2.0 introduces a number of new files to improve open source development with git and GitHub, including a README, a CC-BY 4.0 License, and a .gitignore file. It also prepares the repository for synchronisation with Zenodo, to improve sustainability.
Full Changelog: https://github.com/DHBenelux/jDHBenelux-author-template/compare/v1.1...v2.
Emerging low-carbon urban mega-projects
No full textThis is the author accepted manuscript. The final version is available from Springer via the DOI in this recordThis chapter focuses on the recent trend in some geographical locations (particularly China and the United Arab Emirates) towards building large-scale low-carbon city projects. These low-carbon cities are increasingly being described as mega-projects due to their scale and involvement of large-scale experimental approaches to ways of organizing the low-carbon city. The chapter discusses some of the main trends towards the development of low-carbon eco-city projects since 2000, and then introduces the two main low-carbon city mega-projects currently being developed
Which Canadian Seniors Are Below the Low-Income Measure?
No full textAbout 6% of seniors in Canada have family incomes below the Low-Income Measure. (The Low-Income Measure is 50% of the median family income, adjusted for family size, and is a commonly used, if arbitrary, operational definition of relative poverty.) This is a low rate by international standards, in sharp contrast to the high rate in Canada about 35 years ago. It is lower than the comparable rates for the general Canadian population or for families with children and more Canadians leave below-LIM status during their retirement years than enter it. Canadian income tax data show that the remaining 6% are disproportionately immigrant, female, currently unmarried and supporting dependent children (possibly grandchildren). Age does not appear to be of great importance.relative poverty, Canadian income distribution, pension adequacy
Public perceptions and community issues
No full textThis paper is the seventh in a series of 8 that make up the evidence base for SDC report 'The role of nuclear power in a low carbon economy'.Publisher PD
A solver for clustered low-rank SDPs arising from multivariate polynomial (matrix) programs
No full textIn this thesis, we give a primal-dual interior point method specialized to clustered low-rank semidefinite programs. We introduce multivariate polynomial matrix programs, and we reduce these to clustered low-rank semidefinite programs. This extends the work of Simmons-Duffin [J. High Energ. Phys. 1506, no. 174 (2015)] from univariate to multivariate polynomial matrix programs, and to more general clustered low-rank semidefinite programs. Clustered low-rank semidefinite programs are programs with low-rank constraint matrices where the positive semidefinite variables are only used within clusters of constraints. The free variables can be used in any constraint, and can be used to connect clusters. The solver uses this structure to speed up the computations in two ways. First, the low rank structure is used to reduce matrix products to products of the form uT M v, where M is a matrix and u and v are vectors, as already suggested by Löfberg and Parrilo in [43rd IEEE CDC (2004)]. Second, an additional block-diagonal structure is introduced due to the clusters. This gives the possibility to do operations such as the Cholesky decomposition block-wise. We apply this to sphere packing and spherical cap packing. For sphere packing, the speed of the solver is compared to the often used arbitrary precision solver SDPA-GMP, showing the theoretical speedup in time complexity. We give a new three-point bound for the maximum density when packing spherical caps of sizes on the unit sphere. https://github.com/nanleij/Clustered-Low-Rank-SDP-solver Repository link Github repository with the Julia code of the solverApplied Mathematics | Optimizatio
The 2D/3D dynamics of wall-bounded low-Rm magnetohydrodynamic (MHD) turbulence
No full textWith this experimental study, we give evidence that the dynamics of low-Rm MHD turbulence depends on the diffusion length l_z, which corresponds to the distance over which the Lorentz force is able to diffuse momentum before it is balanced by inertia
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