52 research outputs found
COVID-19 as an effect modifier of the relationship between age and in-hospital survival in older patients admitted to an Italian Emergency Department
No full textBackground: The SARS-CoV-2 pandemic modified how persons got into contact with emergency services, particularly during the first wave. Aim: The aim is to describe the characteristics of older persons with and without COVID-19 visiting the Emergency Department of a tertiary hospital and to investigate the impact of age on in-hospital survival in the two groups. Methods: Patients older than 70 years were followed-up till discharge or in-hospital death. Cox regression models stratified by COVID-19 diagnosis were used to investigate survival. Results: Out of 896 patients, 36.7% had COVID-19. Those without COVID-19 were older and affected by a higher number of chronic conditions but exhibited lower mortality (10.5 vs 48.1%). After the adjustment, age was associated with mortality only among those with COVID-19. Discussion: COVID-19 modified the relationship between older age and in-hospital survival: whether this finding is explained by other biological vulnerabilities or by a selection of treatments based on age should be further investigated
Parenting stress and broader phenotype in parents of children with attention deficit hyperactivity disorder, dyslexia or typical development
No full textIn the present study parenting stress and the broader phenotype are investigated in two highly common developmental disorders, namely Attention Deficit Hyperactivity Disorder (ADHD) and specific reading impairment (dyslexia). Within a total sample of 130 parents, 27 were parents of children with ADHD (P-ADHD), 38 were parents of children with a diagnosis of dyslexia (P-DYS) and the other 65 participants were parents of children with typical development (P-TD). A battery of cognitive tasks was administered which included verbal and non-verbal Intellectual Quotient (IQ), reading speed (passage and nonwords), verbal fluency and the Attention Network Task (ANT). Reading history, symptoms of ADHD in adults and parenting stress were measured through questionnaires. Group differences evidenced that the P-DYS group had lower scores in the reading tasks, in the verbal fluency task and in the reading history questionnaire. Conversely, the P-ADHD group had more transversal cognitive weaknesses (IQ, reading tasks, verbal fluency) and the highest scores in parenting stress and ADHD symptoms, together with poor reading history. The groups did not differ in the ANT task. Parenting stress was predicted, on the whole sample, by lower socioeconomic status (SES) and number of family members and higher ADHD symptoms. Implications for research and clinical settings are discussed. © 2019 by the author. Licensee MDPI, Basel, Switzerland
Correction to: Incidental lowering of otitis-media complaints in otitis-prone children during COVID-19 pandemic: not all evil comes to hurt (European Journal of Pediatrics, (2020), 10.1007/s00431-020-03747-9)
No full textThe family name of the co-author of the article mentioned above was incorrectly spelled
Erratum to: Association Study between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population (Journal of Cardiovascular Translational Research, (2017), 10, 5-6, (455-458), 10.1007/s12265-017-9758-9)
No full textThe author affiliation for both Guido Iaccarino and Michele Ciccarelli is Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno. The currently mentioned affiliations (Department of Advanced Biomedical SciencesFederico II University NaplesItaly and IRCCS SDN Istituto di Ricerca Diagnostica e Nucleare Naples Italy respectively) are not correct
Italy: Legal Response to Covid-19
No full textScholarly report and analysis of national legal responses to Covid-19 around the world. The Compendium is composed of reports by country teams, headed by one or more Country or Territory Rapporteurs, who coordinate the production and updating of the relevant Country Reports. The reports are written by reference to a comprehensive Author Guidance Code (AGC). The AGC covers five topics:
I. Introduction
II. Applicable Legal Framework
III. Institutions and Oversight
IV. Public Health Measures, Enforcement and Compliance
V. Social and Employment Protection Measures
VI. Human Rights of Vulnerable Group
Il Barone rampante di Italo Calvino visto da Marco Belpoliti. Un capolavoro a sessant’anni dalla pubblicazione
No full textThe aim of this essay is to give an explanation of a novel by Italo Calvino, Il Barone
rampante. The work is set on a previous written entitled L’occhio di Calvino by Marco
Belpoliti. That will afford us to have an analysis of the author related to his historical
context
La morte di Pasolini tra macchinazioni di Servizi segreti e di “Palazzo”. Conversazione con David Grieco
No full textConversazione con lo scrittore e regista David Grieco, autore del libro e del film La Macchinazione; uno studio serio, approfondito e comparatistico sulla figura, l’opera e la tragica fine di Pier Paolo Pasolini.Conversation with writer and director David Grieco, author of the book and movie The Machination; seriousstudy, thorough and comparative law on the fi-gure, the work and the tragicdeath of Pier Paolo Pasolini
Análise Net Promoter Score (NPS): estudo de caso da empresa Bodytech Natal Shopping
No full textIn a globalized, borderless world where competition fights for all customers, it has be-come vital for any company to search for the satisfaction of its demand, it is important to understand and know what your customers want. Therefore, the main objective of this study is to analyze through the Net Promoter Score (NPS) tool the level of satis-faction of customers who attend the Natal Shopping Bodytech Academy, in order to achieve this objective, a goal of three other specific points was established, which are, Identify customer segmentation data; point out the perception of customers in relation to health indicators and map the perception of customers about the physical structure of the gym.In order for the results to be achieved, the author used a methodology, descriptive and with exploratory characteristics since we will study a phenomenon, in this research more than 23 thousand responses were recorded from an average of 985 customers, in the period from 01.01.2019 to 31.12. 2019, the sample is non-probabilistic, mathe-matical and statistical methods were not used to determine the number of respondents and at the end the data were collected and developed using the Net Promoter Score (NPS) methodology. The results showed that the investigated academy has been able to satisfy most of its customers in relation to many aspects, such as physical structure and services offered, one point in particular demonstrates the need for improvement, the price, the satisfaction index is below others mentioned, diverging from the philoso-phy of excellence on which the company relies, consequently this factor leaves the organization unable to reach a level of full satisfaction of its client, thus being able to generate consequences in elements such as loyalty or future recommendations, a dan-ger that must be avoided in a corporate world of great dispute.Em um mundo globalizado, sem fronteira em que a concorrência briga por todos os clientes, tornou-se vital para qualquer empresa a busca pela satisfação de sua demanda, é importante entender e saber o que seus clientes desejam. Portanto o principal objetivo desse estudo é analisar através da ferramenta Net Promoter Score (NPS) o nível de satisfação dos clientes que frequentam a Academia Bodytech Natal Shopping. Para o alcance desse objetivo foi traçado uma meta de três outros pontos específicos, que são: identificar os dados de segmentação dos clientes; apontar a percepção dos clientes em relação aos indicadores de saúde e mapear a percepção dos clientes sobre a estrutura física da academia. De maneira que, para os resultados serem alcançados o autor utilizou de uma metodologia descritiva e com características exploratórias, já que estudaremos um fenômeno nessa pesquisa, o qual foi registrado mais de 23 mil respostas vindas de uma total de 985 clientes, no período de 01.01.2019 a 31.12.2019. A amostra é não probabilística, não foi usado métodos matemáticos e estatísticos para determinar a quantidade de entrevistados e ao fim os dados foram coletados e desenvolvidos através da metodologia Net Promoter Score (NPS). Os resultados demonstraram que a academia investigada vem conseguindo satisfazer a maior parte de seus clientes em relação a muitos aspectos, como estrutura física e serviços oferecidos. Um ponto em especial demonstra necessidade de melhora, o preço, o índice de satisfação mostra-se abaixo dos demais citados, divergindo da filosofia de excelência em que a empresa se apoia, consequentemente, esse fator deixa a organização incapaz de atingir um nível de satisfação plena de seu cliente, podendo assim, gerar consequências em elementos como a fidelização ou recomendações futuras, um perigo que deve ser evitado em um mundo corporativo de grande disputa
Harsh Noise Industrial Games : À propos d’une pratique artistique industrielle du jeu vidéo
No full textCet article analyse des créations vidéoludiques récentes à travers le prisme de la culture et de la musique industrielle, créations qui seront catégorisées comme « jeux vidéo industriels ». Face à une effervescence de la production de jeux menée par des concepteurs solitaires depuis 2015, l’auteur identifie comment des pratiques singulières de création vidéoludique peuvent être inspirées par des formes artistiques underground. Afin de guider cette réflexion, des entrevues ont été menées avec cinq créatrices et créateurs : Yames, Selfish Dream, Valerie Dusk, Stef Pinto et Andrea Pignataro. Le texte propose une analyse des correspondances entre leurs stratégies de production et celles de la culture industrielle, notamment en s’intéressant à une utilisation particulière du bruit (sonore, mais aussi visuel et spatial), ainsi qu’à la manière dont ces créations font office de bruit au sein de l’industrie dominante du jeu vidéo, venant ainsi fragiliser ses définitions canoniques et l’histoire technocentriste du médium.This article proposes an analysis of recent alternative video games through the particularities of industrial music’s aesthetics. Considering a massive increase in video game production by solo designers since 2015, the author identifies how singular practices of game creation can be inspired by underground art forms. To further this research, five game developers were invited to participate through interviews: Yames, Selfish Dream, Valerie Dusk, Stef Pinto and Andrea Pignataro. The article proposes an analysis of the common production strategies between industrial culture and these game creators, more precisely by studying the singular use of noise in their games (audio but also visual and spatial) and how their creations act as noise in the context of the dominant video game industry by weakening its core definitions of what games are and the technocentrist history of the medium
Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker
No full textImmune-stimulating antibody conjugates (ISACs) equipped with imidazoquinoline (IMD) payloads can stimulate endogenous immune cells to kill cancer cells, ultimately inducing long-lasting anticancer effects. A novel ISAC was designed, featuring the IMD Resiquimod (R848), a tumor-targeting antibody specific for Carbonic Anhydrase IX (CAIX) and the protease-cleavable Val-Cit-PABC linker. In vitro stability analysis showed not only R848 release in the presence of the protease Cathepsin B but also under acidic conditions. The ex vivo mass spectrometry-based biodistribution data confirmed the low stability of the linker-drug connection while highlighting the selective accumulation of the IgG in tumors and its long circulatory half-life
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