24 research outputs found
De Conivngenda Cvm Tradendis Philosophiae Placitis Eorvndem Historia : Oratio Praemissa Vitis Virorvm Doctissimorvm Qvibvs Svmmi In Philosophia Honores D. XVII Octobris MDCCLXXX In Academia Vitebergensi Tribvti Svnt / A Francisco Volkmar Reinhard Philos. Prof. Pvbl. Extraord. Et Ord. Assess. Ordin.
No full textEnth. die Lebensläufe von Friedrich Christian Baumeister, Karl Joachim Pfotenhauer, Karl Friedrich Liebel, Johann Bernhard Behr, Martin Hermann Junge, Franz Jakob Theodor Meyer, Christian Samuel Kretschmar, Johann Christian Vaupel, August Gotthelf Bruckmeyer, Karl Adolph Beutler, August Gottlob Glasewald, Joseph Friedrich Thierfeld, Ernst Christoph Baumbach, Johann Friedrich Müller, August Friedrich Behnert, Johann David Heinrich Ehwalt, Johann Christian Gottlob Liebe, Johann Christian Palitsch, Benjamin Ferdinand Hermann, Andreas Oehler, Johann Gottlob Wilhelm Pasch, Karl Friedrich Stein, Johann Gottlob Bürger, Johann Wilhelm Pfeiffer u. Johann Friedrich Christian KühnAutopsie nach Exemplar der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Vitenbergae, Litteris Adami Christiani Charisii
Ueber Möglichkeit und Werth einer festen Ueberzeugung in der Religion der Christen : Eine Gedächtnißschrift auf den weyl. Hochwohlehrwürdigen, Großachtbaren und Wohlgelahrten Herrn, Herrn Heinrich Christian Friedrich Schenk, treufleißigen Pfarrer der Gemeinde Mendhausen, wie auch der Löbl. Chursächß. Societät der Liebe und Wissenschaften zu Dresden Circ. II. Adjunct, von M. Christian Samuel Kretschmar, Pfarrern in Loschewitz bey Dresden
No full textGedächtnisschrift auf Heinrich Christian Friedrich Schenk, Pfarrer der Gemeinde Mendhausen, Adjunkt der kursächsischen Gesellschaft der Liebe und Wissenschaften zu DresdenVorlageform des Erscheinungsvermerks: Friedrichstadt, gedruckt bey Gotthelf August Gerlach. - Erscheinungsjahr nach Titelaufnahme der SLUB Dresde
De Rachitide / Consensv Facultatis Medicae, Regiae Fridericianae Dissertationem Inavgvralem Pro Gradv Doctoris Medicinae D. XII. Octobr. MDCCXC. Pvblice Defendet Avctor Ioannes Abr. Carolvs Schreiber Anhaltino-Dessavicvs.
No full textDie Rückseite des Titelblatts ist unbedrucktEnthält Widmung an: "Viro Illvstri Et Experientissimo Kretzschmarr ..."Dissertation, Universität Halle, 1790Vorlageform der Veröffentlichungsangabe: Halae, Typis Hendelianis. - Erscheinungsjahr nach Datierung im Titel bestimm
De Conivngenda Cvm Tradendis Philosophiae Placitis Eorvndem Historia : Oratio Praemissa Vitis Virorvm Doctissimorvm Qvibvs Svmmi In Philosophia Honores D. XVII Octobris MDCCLXXX In Academia Vitebergensi Tribvti Svnt
No full textA Francisco Volkmar Reinhard Philos. Prof. Pvbl. Extraord. Et Ord. Assess. Ordin.Enth. die Lebensläufe von Friedrich Christian Baumeister, Karl Joachim Pfotenhauer, Karl Friedrich Liebel, Johann Bernhard Behr, Martin Hermann Junge, Franz Jakob Theodor Meyer, Christian Samuel Kretschmar, Johann Christian Vaupel, August Gotthelf Bruckmeyer, Karl Adolph Beutler, August Gottlob Glasewald, Joseph Friedrich Thierfeld, Ernst Christoph Baumbach, Johann Friedrich Müller, August Friedrich Behnert, Johann David Heinrich Ehwalt, Johann Christian Gottlob Liebe, Johann Christian Palitsch, Benjamin Ferdinand Hermann, Andreas Oehler, Johann Gottlob Wilhelm Pasch, Karl Friedrich Stein, Johann Gottlob Bürger, Johann Wilhelm Pfeiffer u. Johann Friedrich Christian KühnAutopsie nach Exemplar der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Vitenbergae, Litteris Adami Christiani Charisii
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
Is This Working "Well" for Pediatrics? The Diagnosis and Treatment of Thromboembolic Disease in a Patient With Protein C Deficiency
No full textMethod development in animal models based on catheter interventions and cardiac magnetic resonance imaging
No full textIn dieser Habilitationsschrift werden Arbeiten präsentiert, in denen Methoden
entwickelt wurden, die der Diagnostik oder Therapie angeborener Herzfehler
dienen können. Nach theoretischer Vorüberlegung und Planung wurden die
Methoden am Tiermodell entwickelt und in einigen Bereichen bis zur Anwendung
am Menschen weiterverfolgt. Dadurch werden die Methoden translational in dem
eingangs beschriebenen Sinne (Block 1): als Verbindung von biomedizinischer
Grundlagenforschung, Arzneimittel- oder Medizinproduktentwicklung,
(prä-)klinischer Forschung und ärztlicher Anwendung. Jede der entwickelten
Methoden hat die Anwendung bei Patienten mit kardiovaskulären Erkrankungen zum
Ziel. Es werden Arbeiten zu den drei großen Bereichen des Herz-Kreislauf-
Systems vorgestellt: Myokard, Klappen und Gefäße Am intensivsten wird das
Myokard bearbeitet (hier werden die für diese Habilitation berücksichtigten
Arbeiten präsentiert): die Myokardperfusion, die Myokardarchitektur,
myokardiale Druck-Volumen-Beziehungen und das myokardiale Reizleitungssystem.
Durch Koronarkatheterisierung und MRT-Analyse von Signalintensitätskurven wird
eine neue Methode der Quantifizierung des regionalen myokardialen Blutflusses
[63] entwickelt. Die Auswirkungen des pathologischen myokardialen Blutflusses
bei Patienten mit Bland-White-Garland-Syndrom (ALCAPA) werden mittels
kernspintomographischer Messungen im Median knapp 11 Jahre nach definitiver
operativer Versorgung mittels Re-Insertion der linken Koronarartierie
untersucht.[64] Die Veränderungen der Myokardarchitektur hinsichtlich des
Arrangements von Kardiomyozyten und extrazellulärer Matrix unter
Nachlasterhöhung werden analysiert und die Entstehung des Ungleichgewichtes
zwischen quer und helikal verlaufenden Kardiomyozytenaggregaten
beleuchtet.[36,37] An der Entstehung des Ungleichgewichtes sind chronische
Veränderungen der Druck-Volumen-Beziehungen des Herzens wesentlich beteiligt.
Hierzu wird eine Methode der MR-Katheterisierung vorgestellt, um Druck-
Volumen-Kurven zu erzeugen und daraus die endsystolische, aber auch
enddiastolische Druck-Volumen-Relation zu bestimmen.[38,39,65] Diese geben
Auskunft über die systolische Kontraktilität und die diastolische
Ruhedehnungskurve (Compliance) des Myokards. Nach Etablierung am Tiermodell
wurde die Methode im Menschen angewendet. Hier wurden zusätzlich die
Auswirkungen von Kollateralfluß und pulmonalem Gefäßwiderstand im Univentrikel
untersucht.[39] Zuletzt wird das myokardiale Reizleitungssystem in Form zweier
Arbeiten zu neuen epikardialen Schrittmacherkonzepten bearbeitet: Erstens die
Verwendung bipolarer temporärer Elektroden im unipolaren Modus zur
Überbrückung postoperativer Reizleitungsstörungen [43] und zweitens die
transkutane epikardiale Implantation von Schraubelektroden zur definitiven
Schrittmacherversorgung bei Kindern mit komplexer Herzanatomie unter
Vermeidung des transvenösen Zugangsweges.[44] Im Bereich der Herzklappen
befasste sich der Autor mit seiner Arbeitsgruppe mit der Züchtung und dem
interventionellen Ersatz von Segelklappen. Aufgrund der Erkenntnis, dass
derzeitige xenogene Herzklappen sämtlich infolge einer langsam verlaufenden
Immunreaktion degenerieren, wurde in einem europäischen Konsortium eine
Pulmonalklappe aus autologen bzw. homologen vaskulären Fibroblasten auf einem
Scaffold aus PGA/P4HB durch tissue engineering gezüchtet. Die auf einem
selbstexpandierenden Nitinolstent gezüchtete Klappe wurde dezellularisiert und
dadurch haltbar gemacht. Unter Verwendung eines eigens dafür entworfenen und
hergestellten Ablagesystems [46, 66] wurde die Klappe transjugulär
implantiert. Die Langzeitergebnisse über ein Jahr zeigen ein hervorragendes
Öffnungs- und Schlussverhalten sowie Freiheit von Verkalkung und
Thrombosierung und eine komplette Endothelialisierung. Aus dem Gebiet der
herznahen Gefäße werden zwei Arbeiten vorgestellt. Beide beschäftigen sich mit
dem Ersatz einer operativen Methode durch eine katheterinterventionelle im
Bereich der mehrstufigen Palliation von univentrikulären Herzfehlern: die
erste Arbeit zeigt die minimal-invasive Anlage eines aorto-pulmonalen Shuntes
[54], die zweite demonstriert die interventionelle Schaffung einer Glenn-
Anastomose.[55] Die vorliegende Synopsis von Arbeiten zeigt, dass Tiermodelle
trotz zunehmender Anwendung digitaler Simulationsmodelle in der Translation
kernspinunterstützter Herzkatheter-Interventionen weiterhin benötigt werden.
Die Methodenentwicklung erfordert als letzten Schritt vor der Anwendung am
Menschen die Validierung in einem möglichst menschennahen Organismus mitsamt
seinen Stoffwechsel- und Immunprozessen. Eine methodische Verbesserung
bestehender Interventionen oder der Ersatz operativer Methoden für Patienten
mit angeborenen Herzfehlern werden angestrebt, um die diagnostische
Aussagefähigkeit zu erweitern oder neue therpeutische Möglichkeiten zu
schaffen. Ziel ist das bestmögliche Wachstum von Myokard, Herzklappen und
Gefäßen unter Vermeidung von Re-Operationen und die Prävention von
Langzeitfolgen für die Patienten.This professorial dissertation summarizes original research work on the
development of new diagnostic and therapeutic methods in congenital heart
defects. These methods were theoretically planned for and actually conducted
in large animal models but also pursued to appilation in patients. By this
these methods became translational in the sense of combining biomedical basic
research, medicinal product development, conduction of preclinical trials and
finally application in patients. This research summary considers three major
aspects of the cardiovascular system: the myocardium, heart valves and large
vessels. The main body of the professorial dissertation focuses on the
myocardium: myocardial perfusion, myocardial architecture, myocardial
pressure-volume-relation and the electrical stimulation of the myocardium. By
catheter occlusion and reperfusion of the coronary arteries with simultaneous
MRI analysis of the signal intensity curves of an intravascular contrast agent
a new method for the quantification of regional myocardial blood flow was
established. [63] The long-term impact of pathologic myocardial blood flow in
patients suffering from Bland-White-Garland (ALCAPA) syndrome is evaluated by
cardiac magnetic resonance imaging 11 years after re-establishment of
orthograde coronary blood flow in the largest cohort of direct re-insertion of
the left coronary artery. [64] Changes in the architectural arrangement of
cardiomyocytes and extracellular matrix are analysed during elevated afterload
and the imbalance between intruding and helically oriented aggregates of
cardiomyocyte are investigated. [36,37] That imbalance is provoked by
chronically altered pressure-volume-relations of the ventricles. For the
measurement of even right ventricular systolic and diastolic pressure-volume-
relations a novel MRI catheterization method is introduced [38,39,65], which
describes ventricular systolic contractility and diastolic compliance. After
proof in an animal model the pressure-volume-relations were successfully
measured along with collateral flow and pulmonary vascular resistance in
patients of univentricular morphology.[39] Electrical stimulation of the
myocardium in patients with congenital heart defects was in the focus of
utilizing bipolar electrodes in a unipolar mode to cope with arrhythmias after
cardiac surgery. [43] For patients with complex cardiac anatomy lacking
transvenous access a novel epicardial lead implantation method is presented.
[44] Regarding heart valves the author published articles about tissue
engineered manufacturing and catheter based implantation of semilunar valves.
Substantiated by the knowledge that all current xenogenic valve prostheses
gradually degrade, an international consortium grew tissue engineered
homologous heart valves derived from sheep fibroblasts on a PGD/P4HB scaffold.
The valve was subsequently sewn into a nitinol stent and decellularized. By
such an off-the-shelf product was made available. A delivery catheter system
was custom-made by the author´s working group and successfully used for
transjugular valve deployment. [46, 66] One year follow-up showed superb
opening and closing behavior of the valve, freedom from calcification, no
thrombus formation and complete endotheliazation. In the field of large
vessels two original articles are presented both dealing with a replacement
method of a surgical step of the Fontan procedure by transcatheter means. The
first article describes the minimally invasive establishment of an aorto-
pulmonary shunt in univentricular morphology [54], the second work
demonstrates transcatheter creation of the upper cavo-pulmonary Glenn
anastomosis. [55] In conclusion, the presented synopsis of original research
work reveals that animal models are still needed in translation of novel MRI
supported catheter interventions, despite incremental use of digital
simulation methods. As one last step before first-in-human use the translation
of new methods demands preclinical validation in animals including live
metabolic and immunologic responses. The goal is methodical improvement of
existing catheter interventions or replacement of surgical procedures in order
to increase diagnostic quality and information and to create new treatment
options for patients with congeital heart defects. Best possible growth of
myocardium, heart valves and vessels shall be achieved while avoiding re-
interventions to foster good long-term outcome
Recent changes in the initiation liturgies: a comparative study
No full textIn this thesis the author examines the recent rites of initiation within the Orthodox, Roman Catholic, Church of England, and Methodist Churches. The object is two-fold: (l) to see whether there has been convergence in the recent liturgical practice and theological understanding of initiation; and (2)' to see the extent to which the rites of the present-day mark a deliberate return to the pool of symbolic actions and words that were current in the post-apostolic period (and maybe even earlier).From the witness of Scripture it is felt that no established practice was being set before us at that time, particularly as the primary role of Scripture is as a witness to Christ rather than as a manual of devotion. The establishing of normative procedures for initiation would seem to be a post-apostolic development which took distinctive eastern and western lines of development. The Orthodox Church continues to employ the ancient rites which extend back for over twelve hundred years, and its insistence on the unity of baptism, chrismation and eucharist in theological thought and administration is characteristic. The other denominations express in their recent rites the desire to return to an archetypal service, but at the same time wishing to maintain the validity of a fragmented initiation practice. The Church of England, .and Methodism which grew from it, show increasing use of ceremonial. Most of this had been removed from the Church of England's liturgy at the Reformation. Taking note of recent work by the World Council of Churches the author concludes that convergence in liturgy and theology, though incomplete, has taken place; and further, that faithful witness is borne to the practice and understanding of the early Church of the post-apostolic period. Some aspects may date from the New Testament times
INTEGRAL and XMM-Newton observations of IGR J16418-4532: evidence of accretion regime transitions in a supergiant fast X-ray transient
No full textWe report on combined INTEGRAL and XMM–Newton observations of the supergiant fast X-ray transient (SFXT) IGR J16418-4532. The observations targeted the X-ray eclipse region of IGR J16418-4532's orbit with continuous INTEGRAL observations across ~25 per cent of orbital phase and two quasi-simultaneous XMM–Newton observations of length 20 and 14 ks, occurring during and just after the eclipse, respectively. An enhanced INTEGRAL emission history is provided with 19 previously unreported outbursts identified in the archival 18–60 keV data set. The XMM–Newton eclipse observation showed prominent Fe emission and a flux of 2.8 × 10-13 erg cm-2 s-1 (0.5–10 keV). Through the comparison of the detected eclipse and post-eclipse flux, the supergiant mass-loss rate through the stellar wind was determined as Ṁw = 2.3–3.8 × 10-7 M⊙ yr-1. The post-eclipse XMM–Newton observation showed a dynamic flux evolution with signatures of the X-ray pulsation, a period of flaring activity, structured nH variations and the first ever detection of an X-ray intensity dip, or ‘off-state’, in a pulsating SFXT. Consideration is given to the origin of the X-ray dip, and we conclude that the most applicable of the current theories of X-ray dip generation is that of a transition between Compton-cooling-dominated and radiative-cooling-dominated subsonic accretion regimes within the ‘quasi-spherical’ model of wind accretion. Under this interpretation, which requires additional confirmation, the neutron star in IGR J16418-4532 possesses a magnetic field of ~1014 G, providing tentative observational evidence of a highly magnetized neutron star in a SFXT for the first time. The implications of these results on the nature of IGR J16418-4532 itself and the wider SFXT class are discussed
New insights on accretion in supergiant fast X-ray transients from XMM-Newton and INTEGRAL observations of IGR J17544-2619
No full textXMM–Newton observations of the supergiant fast X-ray transient IGR J17544?2619 are reported and placed in the context of an analysis of archival INTEGRAL/IBIS data that provide a refined estimate of the orbital period at 4.9272?±?0.0004?d. A complete outburst history across the INTEGRAL mission is reported. Although the new XMM–Newton observations (each lasting ?15 ks) targeted the peak flux in the phase-folded hard X-ray light curve of IGR J17544?2619, no bright outbursts were observed, the source spending the majority of the exposure at intermediate luminosities of the order of several 1033?erg?s?1 (0.5–10 keV) and displaying only low level flickering activity. For the final portion of the exposure, the luminosity of IGR J17544?2619 dropped to ?4?×?1032?erg?s?1 (0.5–10 keV), comparable with the lowest luminosities ever detected from this source, despite the observations being taken near to periastron. We consider the possible orbital geometry of IGR J17544?2619 and the implications for the nature of the mass transfer and accretion mechanisms for both IGR J17544?2619 and the supergiant fast X-ray transients (SFXTs) population. We conclude that accretion under the ‘quasi-spherical accretion’ model provides a good description of the behaviour of IGR J17544?2619 and suggests an additional mechanism for generating outbursts based upon the mass accumulation rate in the hot shell (atmosphere) that forms around the neutron star under the quasi-spherical formulation. Hence, we hope to aid in explaining the varied outburst behaviours observed across the SFXT population with a consistent underlying physical model
