540 research outputs found
Author Correction: Combined burden and functional impact tests for cancer driver discovery using DriverPower
No full textAuthor Correction: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
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The contributions of Juan Rosai to testicular pathology with personal remembrances
No full textThe authors summarize their personal interactions with someone for whom they had unbounded admiration, Dr. Juan Rosai. This varied from daily review of cases, to sharing the platform at meetings, being under his tutelage as an author, and co-directing postgraduate courses. These all highlighted the remarkable knowledge of medicine Dr. Rosai had, imparting as he did diagnostic pearls and remarks on the literature including the history of our discipline, often laced with a well-honed sense of humor. The contributions he made to the pathology of the testis are then considered beginning with his role in highlighting a tumor, at the time not particularly well publicized, spermatocytic seminoma. He wrote two major papers on it, one on standard clinical and pathologic aspects, and one on its ultra-structure. The first was associated with his diligent investigation of a prior paper reporting an unusually high number of malignant examples of this tumor but on review that was explained by their representing malignant lymphoma. The organizational skills of Dr. Rosai, and attention to detail, were second to none and shown perhaps most notably with his organizing many courses, but they were also illustrated early in his career when he moderated a symposium on germ cell tumors of the testis which laid the framework for the classification and nomenclature of premalignant lesions. Finally, his almost career-long interest in the entity he codiscovered, Rosai-Dorfman disease, was associated with his reporting testicular involvement by that disorder in his later years. This giant figure in pathology will stand forever in the top tier with other greats who have contributed to the field
Conceptual metaphor meets conceptual change
No full textThis paper argues that the metaphorical representation of concepts and the appropriation of language-based construals can be hypothesized as additional sources of conceptual change alongside those previously proposed. Analyses of construals implicit in the lay and scientific use of the noun energy from the perspective of the theory of conceptual metaphor are summarized. The experientially grounded metaphorical construals identified in both uses help conceptualize the shift from the concrete, naïve to the abstract, scientific understanding of energy. The case of the concept of energy motivates the more general hypothesis that an important part of learning a highly abstract (even mathematical) concept is the appropriation of experientially grounded metaphorical construals implicit in scientific discourse. Pedagogical implications of this proposal are discussed. © 2009 S. 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Navigating the Cancer Transcriptome by Decoding Divergent Oncogenic States.
No full textA new approach decomposes aberrant signaling mediated by an oncogenic mutation into underlying core cellular states that may be more permissive to available therapeutic options. Cell Syst 2017 Aug 23; 5(2):1978-1990
Effect of nanocomposite coating via EPD on bone regeneration and antibacterial properties of additively manufactured porous titanium
No full textMechanical, Maritime and Materials EngineeringBiomedical Engineerin
Application of Strip Model to Edge Column-Slab Connections Loaded with Outward Eccentricity
No full textThe strip model describes a load path prior to failure that can be tailored to a wide range of slabs under concentrated loads, both concentric and eccentric. Eccentric punching shear can occur in concrete slab-column connections subjected to shear and unbalanced moment, such as edge and corner columns. This paper shows how the strip model is applied to experiments of edge column-slab connections tested with outward eccentricities, and compares this approach to the traditional and simplified ACI 318-19 approaches for dealing with eccentric punching shear. This work shows how a lower-bound plasticity-based model can be used for the practical case of the slab-column capacity for edge and corner columns, how it may explain the mechanics behind the ACI code provisions, and can help researchers identify adequate test setups for future experiments.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Concrete Structure
Institutional Reform for Community Participation: Towards Community Adoption of Piped Water Supply Systems in Arsenic Affected Regions of Rural Bangladesh
No full textArsenic contamination of groundwater in Bangladesh is one of the largest naturally occurring groundwater calamity in South Asia. The rural people, about 64% of the population (104 million people) suffer the most from this grand challenge as they are still heavily dependent on groundwater based tubewells which are arsenic contaminated. Government interventions to switch to other arsenic mitigation technologies such Piped Water Supply Systems have not been very successful despite the technology being a long-term feasible solution in arsenic-affected areas. Rural communities find it difficult to make the switch from tubewells to piped water due to issues of high costs, less demand and extensive monitoring requirements of these systems. To align itself with the SGD 6.1 (“Clean Drinking Water for All”) and with the aim to climb WHO/UNICEF’s JMP’s highest ladder for drinking water, the Government of Bangladesh has installed multiple Piped Water Schemes in water-stressed areas. These schemes are technically viable in water-stressed areas and financially supported by the World Bank, UNICEF, WHO and other global organisations. However, at community level, institutionally, they face the challenge of Adoptability and Sustainability. Taking a case study approach, this research aims to suggest strategies that can be implemented to increase community adoption and sustainability of Piped Water Supply Systems in the rural areas of Bangladesh to ensure arsenic-safe water in every household-tap. The goal is to provide institutional insights to a research organisation in Bangladesh. Two relevant methodologies for institutional analysis developed by Nobel Prize Winner Elinor Ostrom: The Institutional Analysis and Development Framework (IAD) and Ostrom’s Design Principles for Governance of Common Pool Resources, are used to tackle this problem. The IAD framework is applied at three different levels of governance (central-local and community) to study the gaps in policy implementation at three different phases of the design process “Planning-Implementation-Community Adoption of Piped Water Schemes”. The findings from the IAD suggest that there are defined gaps between actual policy outcomes and policy expectations. The outcomes of the IAD analysis at each level, are evaluated against six of Ostrom’s evaluation criteria. The design principles are then applied to each of the findings from the evaluation to bridge that gap between actual and desired policy outcomes. Three main design principles, a) Collective-Choice Arrangements, b) Graduated Sanctions and c) Nested Enterprises, support the development of new institutional reforms. Proposed institutional reforms, which are robust in nature, lead to suggesting strategies that that can help to increase rural community adoption and sustainability of piped water supply systems to ensure arsenic-safe water in every household-tap.Engineering and Policy Analysi
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