1,242 research outputs found
C. C. Mehta
No full textOn the life and works of Chandravadan Chimanlal Mehta, b. 1901, Gujarati author
Consumption of Processed Red Meat Increases the Risk of Colorectal Cancer
No full textFall 2014Accompanied by video fil
Mobilities in Religious Knowledge: Phiroz Mehta and the Logics of Transreligiosity in 1970s–80s South London
No full textThis paper examines transreligiosity in the context of the transmission of South Asian concepts of spirituality to the UK in the 20th century. Between the 1920s and 1990s, Indian teacher and author Phiroz Mehta (1902–1994) crossed borders in a colonial and postcolonial shuttling between India and the UK but also transgressed conceptual and practice borders of religion, teaching Indian religious concepts to post-Christian spiritual seekers in 1970s–80s South London. Mehta cultivated an elasticity between many religious and philosophical traditions, recognising the post-institutional fatigue of subjects who sought alternative forms of ‘belonging without believing’. Privileging the domestic space for teaching, as well as transitory ‘camp’ gatherings in the UK and Germany, Mehta often operated in the social margins, combining teachings from Hinduism, Buddhism, and Christianity with Zoroastrianism, Judaism (specifically Kabbalah), and Daoism. He offered his tutees the freedom to practice religion in whatever way they chose by drawing on a broad range of traditions concurrently to create a transreligiosity. This paper examines Panagiotopoulos and Roussou’s ‘transgressional webs of practising individualised forms of alternative spirituality’ in relation to Mehta’s followers in the 1970s-1980s and asks how transreligiosity relates to other theoretical analyses, such as religious exoticism, bricolage, religious appropriation, cultural re-articulation or assemblage. This paper focuses on qualitative interviews with original members of the Mehta community conducted between 2021 and 2022.</p
Design and development of a mechatronic training simulator for adult ECMO
No full textWidespread adoption of Extracorporeal Membrane Oxygenation (ECMO) in adults has been limited by unfamiliarity with the procedure, including cannulation and safe handling of the ECMO equipment. We present the design and development of a mechatronic training simulator for ECMO that can help medical professionals acquire the needed skills, gain familiarity, and reduce errors by practicing before performing the procedure on real patients. The trainer is designed as an ultrasound-compatible, wholesome simulator with realistic components such as synthetic blood vessels, cannulation pads, and a color-changing blood simulant to simulate oxygenation and deoxygenation. The simulator is integrated with a mathematical model of human physiology to simulate real-time patient vitals and training scenarios, and to control the trainer hardware. We present results related to successful cannulation under ultrasound scanning and a simple patient scenario of hypovolemia.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2021-05-01The student, Iti Mehta, accepted the attached license on 2019-04-24 at 10:58.The student, Iti Mehta, submitted this Thesis for approval on 2019-04-24 at 11:11.This Thesis was approved for publication on 2019-04-24 at 12:45.DSpace SAF Submission Ingestion Package generated from Vireo submission #13873 on 2019-08-22 at 15:08:02Made available in DSpace on 2019-08-23T20:36:09Z (GMT). No. of bitstreams: 2
MEHTA-THESIS-2019.pdf: 84393765 bytes, checksum: 74f0edf247057995595372eb8076e513 (MD5)
LICENSE.txt: 4206 bytes, checksum: 30fb64a86cfc352d6579ccb023b2a936 (MD5)
Previous issue date: 2019-04-24Embargo set by: Seth Robbins for item 112203
Lift date: 2021-08-23T20:36:18Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 112203 on 2021-08-24T09:15:24Z
Optimal Bioeconomic Management Strategies for Prevention and Control of Invasive Alien Species
No full textPaper removed by author. Please see the current version, available online January 8, 2007: Mehta, S.V. et al. Optimal detection and control strategies for invasive species management. Ecological Economics (2007), doi:10.1016/j.ecolecon.2006.10.024Environmental Economics and Policy,
Investigation into the mechanism of action and chemical enhancement of transdermal iontophoreses of LHRH
No full textRecent developments in drug design and advances in mapping of the human genome have quickened the pace of development of peptide and protein drugs. Unfortunately, this class of compound often has specialised delivery requirements that preclude administration via traditional routes due to biological barriers, physicochemical drug properties, and issues of pharmacokinetics and pharmacodynamics. Transdermal drug delivery has advantages over other routes of administration. Also, the use of an external driving force, such as iontophoresis, is a technique that is well suited for delivery of these compounds. However, the large molecular size of peptides may limit the amounts of drug that can be delivered across the skin barrier. In this study the potential to enhance transdermal iontophoretic delivery of peptides was investigated. Two approaches to this were used: manipulating electrical field strengths to induce structural changes in the skin; and combining a chemical permeation enhancer with iontophoresis to determine if peptide delivery could be synergistically enhanced. In vitro permeability investigations were performed through human epidermal membrane (HEM) using the model peptide, luteinizing hormone releasing hormone (LHRH). Increasing the electrical field strength across the HEM resulted in marked porosity changes above 1 V. This was accompanied by dramatic increases in permeability enhancement of a small ionic solute, tetraethylammonium bromide (TEAB). However, the increases that were observed in LHRH permeability enhancement was several orders of magnitude less. The modified Nernst-Planck model, after correction for porosity changes, predicted results that matched the observed TEAB enhancement. However, LHRH enhancement predictions were markedly different from observed values indicating that the electrically-induced pathways were largely unavailable for LHRH transport, a finding that is consistent with recent reports characterising these pores. The influence of the voltage-induced pores on electroosmosis was also studied, since this transport mechanism is more important as molecular size increases. Sucrose, a small non-ionic polar solute, was used as an electroosmotic flow marker during these investigations. The enhancement of sucrose closely mirrored porosity increases in the membrane indicating considerable electroosmosis occurs within electrically-induced pores. These two parallel investigations showed moderate voltage iontophoresis (> 1 V) causes the induction of pores in the HEM, however, transport through these pores, despite significant electroosmosis, is limited to small solutes. The potential for synergism between iontophoresis and chemical enhancers to improve peptide delivery was investigated. It was hypothesised that oleic acid (OA) may cause synergistic enhancement of LHRH during iontophoresis by increasing the pore sizes of the HEM. Synergistic enhancement of LHRH was observed. Permeability and conductance changes, in addition to structural investigations (differential scanning calorimetry (DSC) and infrared spectroscopy (IR)) were also performed. OA treatment of the skin promoted the permeability of LHRH, sucrose, and TEAB during passive conditions. This suggests that pre-existing pores in the membrane increased in size. However when the enhancer was used in combination with iontophoresis, LHRH was the only solute to be co-enhanced. This finding was consistent with increases in pore size of the pre-existing pores in the stratum corneum as modelled using the hindered pore theory. Co-enhancement of LHRH may also be due to an effect of the enhancer on the accumulation of peptide in the stratum corneum. Interestingly, disruption of the fixed negative charges on the skin by the enhancer may have negatively influenced transport via decreases in electroosmosis. The disordered effect caused by the action of oleic acid on the stratum corneum was confirmed using DSC and IR investigations. In summary, the transport of peptides across the skin during iontophoresis may become less restricted following the pre-treatment of the barrier with suitable chemical permeation enhancers
Investigation into the mechanism of action and chemical enhancement of transdermal iontophoreses of LHRH
No full textRecent developments in drug design and advances in mapping of the human genome have quickened the pace of development of peptide and protein drugs. Unfortunately, this class of compound often has specialised delivery requirements that preclude administration via traditional routes due to biological barriers, physicochemical drug properties, and issues of pharmacokinetics and pharmacodynamics. Transdermal drug delivery has advantages over other routes of administration. Also, the use of an external driving force, such as iontophoresis, is a technique that is well suited for delivery of these compounds. However, the large molecular size of peptides may limit the amounts of drug that can be delivered across the skin barrier. In this study the potential to enhance transdermal iontophoretic delivery of peptides was investigated. Two approaches to this were used: manipulating electrical field strengths to induce structural changes in the skin; and combining a chemical permeation enhancer with iontophoresis to determine if peptide delivery could be synergistically enhanced. In vitro permeability investigations were performed through human epidermal membrane (HEM) using the model peptide, luteinizing hormone releasing hormone (LHRH). Increasing the electrical field strength across the HEM resulted in marked porosity changes above 1 V. This was accompanied by dramatic increases in permeability enhancement of a small ionic solute, tetraethylammonium bromide (TEAB). However, the increases that were observed in LHRH permeability enhancement was several orders of magnitude less. The modified Nernst-Planck model, after correction for porosity changes, predicted results that matched the observed TEAB enhancement. However, LHRH enhancement predictions were markedly different from observed values indicating that the electrically-induced pathways were largely unavailable for LHRH transport, a finding that is consistent with recent reports characterising these pores. The influence of the voltage-induced pores on electroosmosis was also studied, since this transport mechanism is more important as molecular size increases. Sucrose, a small non-ionic polar solute, was used as an electroosmotic flow marker during these investigations. The enhancement of sucrose closely mirrored porosity increases in the membrane indicating considerable electroosmosis occurs within electrically-induced pores. These two parallel investigations showed moderate voltage iontophoresis (> 1 V) causes the induction of pores in the HEM, however, transport through these pores, despite significant electroosmosis, is limited to small solutes. The potential for synergism between iontophoresis and chemical enhancers to improve peptide delivery was investigated. It was hypothesised that oleic acid (OA) may cause synergistic enhancement of LHRH during iontophoresis by increasing the pore sizes of the HEM. Synergistic enhancement of LHRH was observed. Permeability and conductance changes, in addition to structural investigations (differential scanning calorimetry (DSC) and infrared spectroscopy (IR)) were also performed. OA treatment of the skin promoted the permeability of LHRH, sucrose, and TEAB during passive conditions. This suggests that pre-existing pores in the membrane increased in size. However when the enhancer was used in combination with iontophoresis, LHRH was the only solute to be co-enhanced. This finding was consistent with increases in pore size of the pre-existing pores in the stratum corneum as modelled using the hindered pore theory. Co-enhancement of LHRH may also be due to an effect of the enhancer on the accumulation of peptide in the stratum corneum. Interestingly, disruption of the fixed negative charges on the skin by the enhancer may have negatively influenced transport via decreases in electroosmosis. The disordered effect caused by the action of oleic acid on the stratum corneum was confirmed using DSC and IR investigations. In summary, the transport of peptides across the skin during iontophoresis may become less restricted following the pre-treatment of the barrier with suitable chemical permeation enhancers
Design and implementation of a phase locked loop for high-speed serial links
No full textThe student, Rushabh Mehta, accepted the attached license on 2016-04-25 at 13:40.The student, Rushabh Mehta, submitted this Thesis for approval on 2016-04-25 at 13:46.This Thesis was approved for publication on 2016-04-27 at 14:52.DSpace SAF Submission Ingestion Package generated from Vireo submission #9475 on 2016-07-07 at 13:50:45Made available in DSpace on 2016-07-07T20:27:59Z (GMT). No. of bitstreams: 2
MEHTA-THESIS-2016.pdf: 13984347 bytes, checksum: 4ecb06c5c270bc1beffb061eeae85eef (MD5)
LICENSE.txt: 4210 bytes, checksum: e6aea67d4e02d64f06671bb40ada2274 (MD5)
Previous issue date: 2016-04-27Recent advances in the semiconductor industry and process technology scaling have increased the demand for fast, robust computing. The thirst for high-processing, low power ICs is ever increasing. This has pushed the demand for high data rates in wireless and wireline communication systems in the multi-Gbps range. With higher data rates, the I/O links need to scale proportionally. However, the I/O channel bandwidth has not scaled appropriately making it the biggest bottleneck in high-speed links. Parallel links have not been able to match this increasing system performance due to issues such as crosstalk, timing skew and packaging costs. Thus there is a need for high-speed serial links. For high-speed transmission of data, there arises a need for high-speed on chip clocking circuits making the use of Phase-Locked Loops (PLLs) imperative.
This thesis includes an overview of high-speed links along with the need for PLLs. An in-depth understanding of PLL theory, loop dynamics and behavioral and transistor level simulation follows. Performance metrics such as phase noise, random jitter and deterministic jitter are discussed. Finally, this thesis concludes with an insight into All Digital Phase-Locked Loops (ADPLLs).Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-05-01Embargo set by: Seth Robbins for item 93174
Lift date: 2018-07-07T20:28:14Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 93174
Lift date: 2018-07-07T20:35:34Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 93174 on 2018-07-08T09:15:20Z
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