6 research outputs found
Le récit de la création picturale dans la littérature française du XIXe siècle
No full textThis dissertation aims at analysing a specific literary genre which focuses on artistic creation and, more specifically, on the failure of the painter’s creative power. This literary form has been interpreted by critics as one of the reactions by novelists to the fracture between the two sister arts – painting and literature -, a fracture caused by the decline of the ancient ut pictura poesis doctrine. The current work will try to demonstrate that this theoretical principle still had influence on French literary creation even after the publication of Lessing’s Laocoon, which historically represents the ultimate fracture between literature and painting.
The analysis carried out in this work focuses on the two main elements of the ut pictura poesis principle, namely the opposition between painting and colour, and the supremacy of literature over painting.
As for the former, this dissertation will attempt to demonstrate how the stereotypes that originated from the so-called querelle du coloris actually helped the establishment of a strong connection between chromatic elements and madness. In the novels analysed in this work, colour is no longer seen as the source of life, but as the means through which the artist gives shape to his obsessions.
The supremacy of literature over painting will be investigated from different angles: firstly, the analysis will try to identify the nature of the relationship of the main character of the novels – the painter –with both his own author and with the other characters of the texts under investigation. On the basis of previous critical works, this dissertation will then try to show that the painter is his own creator’s alter ego, who frees himself from his dangerous obsessions through the mise à mort of his own creation.
Besides the main character – the painter - the observation of the various characters of the novels under analysis will highlight the recurring presence of a further artist – a novelist or a painter himself – who acts as a mediator between the main character and his audience. This additional character seems to embody the novelist’s more rational and socially acceptable traits, which make him superior to the painter himself. The new role of the novelist as critique d’art and as the painter’s mentor seems to suggest a nostalgic view of the role of literature, which, according to the ancient ut pictura poesis principle, is meant to predominate over painting.On the basis of these observations, this work will propose the use of the new terms Other Id and Other Ego to identify – respectively - the painter, in other words the embodiment of the author’s negative features, and the mentor.
This dissertation will even look at the concept of the supremacy of literature over painting by analyzing the authors’ stylistic choices, which also seem to originate from the rivalry between the two arts and find their perfect personification in the Other Id and Other Ego.La presente tesi verte sull’analisi di un filone del romanzo francese dell’Ottocento che ha al suo centro il tema della creazione pittorica e, in particolare, del fallimento del pittore. Tale tema è già stato interpretato dalla critica come una delle risposte che il letterato oppone all’allontanamento delle due arti sorelle – pittura e letteratura –, dovuto all’eclissi della secolare dottrina dell’ut pictura poesis. Questo lavoro intende dimostrare come tale principio teorico sopravviva anche dopo la pubblicazione del Laocoonte di Lessing (1766), l’opera cui tradizionalmente viene fatta risalire la definitiva separazione tra gli ambiti della creazione letteraria e di quella pittorica. È proprio nel romanzo incentrato sulla creazione pittorica che il presente lavoro identifica il terreno su cui il principio dell’ut pictura poesis in realtà continua a prolificare, almeno nei suoi tratti essenziali.
Tra questi ultimi sono stati individuati e analizzati in particolare l’opposizione tra disegno e colore, e la supremazia della letteratura sulla pittura.
Per quanto concerne la querelle du coloris, in questa tesi si dimostra che gli stereotipi attribuiti al colore nel corso di tale diatriba hanno contribuito alla formazione, all’interno delle opere analizzate, di uno stretto legame tra l’elemento cromatico e il demoniaco o la follia. La capacità di dare la vita, da sempre attribuita al colore, viene così relegata alla produzione di vere e proprie ossessioni del creatore.
L’altro caposaldo dell’ut pictura poesis, ovvero la supremazia dell’arte letteraria su quella pittorica, viene indagato attraverso diverse piste d’analisi. Esso è stato innanzitutto ricercato nei rapporti che il pittore protagonista intrattiene con il proprio autore e con gli altri personaggi dei testi analizzati. Si è quindi evidenziato, secondo studi critici precedenti, come il pittore costituisca l’alter ego del suo creatore, il quale espia le proprie pulsioni pericolose attraverso la mise à mort della sua creatura.
Il confronto tra i personaggi ha messo in luce la frequente presenza, accanto al pittore protagonista, di una figura, anch’essa artista, pittore o letterato, che si pone come guida e mediatore tra il personaggio principale e il suo pubblico, essendo quest’ultimo incapace di comprendere e accettare le innovazioni apportate dal protagonista nell’ambito della propria arte. Tale figura d’intermediario riunisce il nuovo ruolo di critico d’arte che il letterato si è ritagliato nella società moderna e la sua antica funzione di guida del pittore, testimoniando al contempo una nostalgia letteraria dell’antica egemonia della poesia sulla pittura. Inoltre, questo stesso personaggio rappresenta un’ulteriore emanazione della personalità dell’autore, ma, in questo caso, non più dei suoi tratti oscuri, bensì di quelli più rassegnati e socialmente accettabili. Di conseguenza, nel corso della trattazione non solo si riconosce una velata superiorità del personaggio-guida – ovvero del personaggio-scrittore, quando presente nella narrazione –, ma si propone inoltre di sostituire il termine comunemente utilizzato di alter ego, con Altro Es, da attribuire al protagonista, e Altro Io, corrispondente al personaggio-guida.
La persistenza dell’idea della supremazia della letteratura sulla pittura viene rinvenuta anche nell’ambito delle scelte stilistiche degli autori, oltre che in altri aspetti significativi dei romanzi analizzati, che riflettono chiaramente la rivalità tra le due arti. Esse sono infatti costantemente messe in contrapposizione attraverso le figure dei loro rispettivi rappresentanti fittizi o, in alcuni casi più complessi, mediante una sorta di competizione tra il pittore e il suo stesso creatore, cioè lo scrittore, che attua così una mise en abyme
Créer une Entreprise au Mali : les défis et les perspectives pour les femmes
No full text112 p.:ill;30cm.(+cd)L’entrepreneuriat constitue une source de création d’emplois ainsi qu’un moteur de développement économique majeur de notre société. En ce sens, la présence des femmes en affaires est devenue une préoccupation des politiques publiques du Mali. Plusieurs leviers ont été mis en place pour stimuler l’entrepreneuriat dans l’optique de contribuer à faire croître le nombre de femmes en affaires. Toutefois, en dépit de ces mesures, le constat selon lequel les femmes sont moins nombreuses que les hommes à entreprendre persiste dans le temps. Cela étant, si les femmes sont sous-représentées dans l’écosystème entrepreneurial, elles manifestent pourtant des intentions entrepreneuriales dans des proportions encourageantes qui se rapprochent des statistiques observées chez les hommes. De ce fait, il est permis de croire qu’un ralentissement de leur élan entrepreneurial se produit une fois les actions de démarrage de l’entreprise enclenchées.
Par cette recherche, nous cherchons à comprendre les facteurs qui agissent sur le cheminement entrepreneurial des femmes jusqu’à l’aboutissement du projet. Notre étude s’inscrit dans la théorie de l’Approche globale entrepreneuriale. La question que nous nous posons est la suivante : quels facteurs expliquent l’aboutissement des démarches entrepreneuriales chez les femmes au Mali ?
Ainsi, à travers une approche quantitative, les résultats d'une enquête effectuée auprès de 30 femmes entrepreneure Tes du secteur informel dans la commune du district de Bamako montrent que la majorité des femmes entrepreneures de notre échantillon (62,26%) pratiquent un entrepreneuriat de nécessité. Ces femmes se sont lancées dans l'entrepreneuriat soit pour subvenir aux besoins de leurs familles ou parce qu'elles ont des difficultés à trouver un emploi. En somme, le projet aura permis de mieux comprendre les différentes réalités vécues par les femmes dans toute leur complexité, en plus de proposer des pistes de solutions pour accroitre la présence des femmes en entrepreneuriat au Mali
STUDIES ON THE ISSUES AND CONCERNS OF TEACHERS IN THE IMPLEMENTATION OF THE K-12 CURRICULUM: A SYNTHESIS
No full textAbstract: According to the K to 12 Deped Primer (2011), "K-12 means "Kindergarten and the 12 years of elementary and secondary education." Kindergarten points to the 5-year-old child who undertakes the standardized curriculum for preschoolers. Elementary education refers to 6 years of primary school (Grades 1-6) while secondary education means four years of junior high school (Grades 7-10 or HS Year 14). In addition to this, two years are now allotted for senior high school (Grades 11-12 or HS Year 5-6)". According to the DepEd discussion paper, at the core of this basic education program is "the complete human development of every graduate". The K-12 curriculum aims to enable every child "to achieve mastery of core competencies and skills", and develop tracks based on the student's interests and competencies. The focus of K-12 is twofold: curriculum enhancement and transition management. This is a synthesis of the related studies on the issues and concerns of teachers in the implementation of educational curricula. It particularized the similarities and differences of these studies in terms of the different components of research.
Keywords: Curriculum; DepEd; Issues and Concerns; K-12 Program; Related Studies; Synthesis; Teachers.
Title: STUDIES ON THE ISSUES AND CONCERNS OF TEACHERS IN THE IMPLEMENTATION OF THE K-12 CURRICULUM: A SYNTHESIS
Author: Tenin Shitra Calvin Abbas
International Journal of Novel Research in Education and Learning
ISSN 2394-9686
Vol. 10, Issue 2, March 2023 - April 2023
Page No: 12-15
Novelty Journals
Website: www.noveltyjournals.com
Published Date: 15-March-2023
DOI: https://doi.org/10.5281/zenodo.7736057
Paper Download Link (Source)
https://www.noveltyjournals.com/upload/paper/STUDIES%20ON%20THE%20ISSUES-15032023-1.pdfInternational Journal of Novel Research in Education and Learning, ISSN 2394-9686, Novelty Journals, Website: www.noveltyjournals.co
Histoire des doctrines économiques depuis les physiocrates jusqu'à nos jours /
No full text2d ed. rev. & aug.Mode of access: Internet
Los esclavizados en Hispanoamérica a mediados del siglo XVII. Estimaciones de un memorial de 1644
No full textBefore and after the Portuguese Secession, urgent requests for slave labour to assist with the economic development of the Spanish West Indies reached Madrid. Under the pretext of his protracted stay in Brazil, Fernando de Silva Solís took advantage of the situation to submit a project. Although apparently well documented, it contained serious numerical inaccuracies. This, in addition to the origins of its author, may help explain its rejection.Antes y después de la secesión de Portugal, comenzaron a llegar a Madrid urgentes demandas de mano de obra servil para impulsar el desarrollo económico de las Indias Occidentales. Bajo el pretexto de su prolongada estadía en Brasil, Fernando de Silva Solís aprovechó la coyuntura para proponer un proyecto. Aunque aparentemente bien documentado, su propuesta presentaba graves imprecisiones numéricas que probablemente explican su rechazo, a lo que probablemennte también contribuyó el origen del autor
Low-dose Gemtuzumab-Ozogamicin as post-consolidation therapy in elderly patients with acute myeloid leukaemia: a pilot study.
No full textThe incidence of acute myeloid leukemia (AML) increases with
advancing age, and in older patients the chance of cure has not
substantially improved recently. In the elderly the incidence of
secondary AML is high, and is often associated with both high-
risk cytogenetic abnormalities and expression of the multidrug
resistance protein (MDR1) and p-glycoprotein (p-gp), both of
which are associated with poor outcomes (Appelbaum et al,
2006).
Gemtuzumab-Ozogamicin (GO) is a humanized anti-CD33
monoclonal antibody conjugated to Calicheamicin that is
rapidly internalized after binding to CD33. GO seems to be
more selective than conventional chemotherapy, as CD33 is
expressed on AML cells but not in normal haematopoietic
stem cells (SCs) or in non-haematopoietic tissues (Sievers et al,
2001). In a series of phase II studies including 142 patients
with AML in first relapse, GO monotherapy was associated
with a 30% overall complete remission (CR) rate, including a
26% rate in patients over 60 years of age (Sievers et al, 2001;
Larson et al, 2002). These results led to US Food and Drug
Administration approval of GO for the treatment of patients
over 60 years with relapsed AML (Bross et al, 2001). As a
consequence of these results, there is interest in extending the
use of GO to a frontline treatment for AML in combination
with conventional chemotherapy.
Little is known about the usefulness of GO as consolidation
and/or maintenance therapy, and no data on the topic have
been published to date. In particular, there are no data
concerning the safety and efficacy of GO in the setting of
post-consolidation therapy in AML patients except for a short
report concerning the effects after autologous stem cell
transplantation (ASCT) (Cascavilla et al, 2008). GO mono-
therapy has typically been administered as a 2-h infusion at a
dose of 9 mg/m2 on days 1 and 15 of treatment, but the
administration of fractionated doses has recently been reported
to have a better safety profile (Taksin et al, 2007).
We evaluated the efficacy of low-dose GO as late
consolidation therapy after CR in a subset of fit elderly
patients who were enrolled in a prospective study. From June
1999 to December 2007, 125 patients of 60 years of age or
older with morphologically-confirmed AML and non-acute
promyelocytic leukaemia were observed in our institution. The
preliminary results from 42 patients were reported in 2007
(Olivieri et al, 2007). Fit patients, selected according to
previously published inclusion criteria (Olivieri et al, 2007),
were treated with intensive chemotherapy, followed by SC
mobilization and ASCT (Olivieri et al, 2007). Patients who
successfully mobilized SCs underwent ASCT, while poor
mobilisers received a further consolidation including standard
chemotherapy or investigational immunotherapy with GO.
Among the initial 125 patients, 79 fulfilled the inclusion
criteria; of those, 56 (72Æ1%) achieved CR, and 52 received the
first intensive consolidation course followed by G-CSF to
collect SC for ASCT. In cases of mobilisation failure, patients
were allowed to chose between an experimental approach
B J H 8 1 6 8 B Dispatch: 8.3.10 Journal: BJH CE: Varun Kumar
Journal Name Manuscript No. Author Received: No. of pages: 3 PE: Subhashree
Table I. Clinical and biological characteristics of the three groups of
patients receiving consolidation with GO (A), ASCT (B), Chemo-
therapy (CHT) (C) and Allogeneic Transplantation (D).
A (%) B (%) C (%) D (%) P
Gender
Male 8 (62) 8 (42Æ1) 3 (50) 3 (60) N.S.
Female 5 (38) 11 (57Æ9) 3 (50) 2 (40)
Age (years)
Median = 70 (range, 61–76)
£70 7 (54) 10 (52Æ6) 5 (83Æ3) 4 (80) N.S.
>70 6 (46) 9 (47Æ4) 1 (16Æ7) 1 (20)
FAB subtype
M0 0 5 (26Æ5) 0 0 N.S.
M1 3 (23) 4 (21) 2 (33Æ3) 2 (40)
M2 3 (23) 8 (42) 4 (66Æ7) 2 (40)
M4 3 (23) 2 (10Æ5) 0 1 (20)
M5 3 (23) 0 0 0
M6 1 (8) 0 0 0
M7 0 0 0 0
Leucocytosis (·109/l)
WBC <10 8 (61Æ5) 9 (47Æ4) 4 (66Æ7) 4 (80) N.S.
WBC 10–50 5 (38Æ5) 6 (31Æ6) 1 (16Æ7) 1 (20)
WBC >50 0 4 (21) 1 (16Æ7) 0
Karyotype
Poor 2 (15Æ4) 7(36Æ8) 1 (16Æ7) 4 (80) N.S.
Intermediate 6 (46Æ2) 8 (42Æ1) 4 (66Æ7) 0
Favourable 2 (15Æ4) 0 1 (16Æ7) 1 (20)
NE 3 (15Æ4) 4 (21Æ1) 0 0
Secondary disease*
Yes 3 (23) 8 (42) 2 (33Æ3) 1 (20) N.S.
No 10 (77) 11 (58) 4 (66Æ7) 4 (80)
FAB, French-American-British classification; NE, not evaluated; WBC,
white blood cell.
*To chemotherapy or Myelodysplastic Syndrome.
correspondence
a 2010 Blackwell Publishing Ltd, British Journal of Haematology doi:10.1111/j.1365-2141.2010.08168.x
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including low-dose GO or a further conventional consolidation
course. GO was administered on a compassionate basis, and the
costs were charged to our department. Among the 52 patients
who received intensive consolidation, two died and seven
relapsed; thus, 43 patients were evaluable for post-remission
treatment after the SC mobilization attempt. Of those, 19
patients (44%) successfully mobilized SC and received ASCT.
Of the 24 that did not mobilise SC, 13 received GO, six patients
refused GO and received a second consolidation with chemo-
therapy, and five patients received reduced intensity
conditioning allogeneic transplant from sibling donors.
The current analysis did not include all patients receiving
allogeneic transplant because of the poor prognosis of the
disease. The disease characteristics of the remaining patients
were equally distributed in the three groups, and the data are
shown in Table I.
All the patients received GO at a dose of 3 mg/m2 three
times monthly on an outpatient basis and received common
antimicrobial prophylaxis. No patients needed hospitalisation
for infections or other major toxicities; the median duration of
neutropenia (PMN <0Æ5 · 109/l) after GO was 12 d (range
0–33 d). The main toxicities (World Health Organization
grade III–IV) were myelosuppression (n = 9), hypertransam-
inasaemia (n = 1) and anaphylaxis (n = 3); no major unex-
pected adverse events were observed. With a median follow up
of 58 months (range 19–89), a total of 15 patients were alive
and in CR: five received ASCT (median follow-up 77 months,
range 45-89), nine received GO (median follow-up 38 months,
range: 19–75 months), and one, who received chemotherapy,
has been followed for 72 months. Two patients receiving GO
relapsed and eventually died after 13 and 19 months from CR
after the first consolidation. Two more patients relapsed after
15 and 32 months after a second CR after salvage chemother-
apy, followed by three doses of GO 3 mg/m2 administered as
consolidation therapy.
In conclusion, nine of the 13 patients who received GO as
late consolidation therapy were alive and in continuous CR
(including two patients with secondary AML and two with a
complex karyotype). The Landmark survival analysis showed
better overall survival (OS) and disease-free survival (DFS)
(P = 0Æ017 and 0Æ01 respectively) in the 13 patients that
received GO (5-year OS, 60%; 5-year DFS, 67%) compared
with patients that received either ASCT (5-year OS and DFS:
26%) or chemotherapy (5-year OS and DFS: 17%) (Fig 1).
Our preliminary data support a potential role for low-dose
GO in consolidation therapy in elderly patients with AML
who are able to achieve CR after intensive induction. Late
consolidation with low-dose GO seems to be safe and easily
manageable; the myelosuppression was relevant, but generally
short. All patients received the 3 GO infusions on an
outpatient basis without further readmissions and without
fatal events.
These preliminary data encourage the use of low-dose GO as
late consolidation therapy to eliminate the minimal residual
disease (MRD) in older patients with AML. Larger studies are
needed for confirmation, possibly including monitoring of
MRD during treatment. It also remains to be established if SC
collection failure after CR represents an independent favour-
able prognostic factor in AML patients, as suggested by some
retrospective data (Keating et al, 2003).
Antonella Poloni1
Debora Capelli1
Silvia Trappolini1
Benedetta Costantini1
Mauro Montanari1
Guido Gini1
Ilaria Scortechini1
Giorgia Mancini1
Giancarlo Discepoli2
Pietro Leoni1
Attilio Olivieri3
1Dipartimento di Scienze Mediche e Chirurgiche, Sezione di Ematologia,
Universita` Politecnica delle Marche and Azienda Ospedaliera Ospedali
Riuniti, 2Laboratorio di Citogenetica e Genetica Molecolare, Clinica di
Pediatria, Ospedali Riuniti, Ancona, and 3Azienda Ospedaliera San
Carlo, Potenza, Italy.
E-mail: [email protected]
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100
0 12 24 36 48 60 72 84 96
Cumulative probability (%)
Months
OS
GO
ASCT
CHT
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20
40
60
80
100
0 12 24 36 48 60 72 84 96
Cumulative probability (%)
Months
DFS
Fig 1. Comparison of the outcome (OS and DFS) of patients receiving late consolidation with Gemtuzumab-Ozogamicin (GO), autologous stem cell
transplantation (ASCT) or chemotherapy (CHT) (log rank test).
Correspondence
2 a 2010 Blackwell Publishing Ltd, British Journal of Haematology
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Keywords: AML, chemotherapy,
