32 research outputs found

    Symposium 2022: The Lessons of Justinian\u27s Code

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    In celebration of National Archives Month, the Duquesne Center for Legal Information and Gumberg Library will showcase the Allegheny County Law Library\u27s 1488 Koberger Imprint of Justinian\u27s Code. A panel of scholars address this treasured book and its foundational contents. Panelists: Dr. Sara Baron, The Duquesne University Librarian since 2015, Introductory Remarks. Bernard Hibbitts, Law professor at the University of Pittsburgh School of Law and the Publisher & Editor-in-Chief of JURIST (jurist.org). His presentation: Justinian\u27s Attorneys: Roman Law and American Lawyers . Hon. Bill Stickman, Judge of the Western District of Pennsylvania and adjunct faculty at Duquesne University, History Department. His presentation: “Justinian’s Code—a buried treasure awaiting rediscovery.” Tom White, The University Archivist and Curator of Special Collections at Duquesne University since 2005, adjunct professor of history at Duquesne University, and at La Roche University, and author of 11 books on Pennsylvania folklore and history. He received his Masters in Public History at Duquesne. His presentation: “The 1488 imprint: Creation , Provenance and Preservation.” Dr. Dana Neacsu, Esq. The DCLI and Allegheny County Law Library Director and Associate Professor of Legal Skills, at Duquesne Kline Law School Her presentation: “The Relevance of Roman Law in the 21st Century Law School Curriculum – A Brief Comparative Perspective.” Producer - Kathleen Lynch, JD, DCLI Research Librarian Editor - Dr. Nichole Scarlet

    Activity, safety, and feasibility of cidofovir and imiquimod for treatment of vulval intraepithelial neoplasia (RT3VIN): a multicentre, open-label, randomised, phase 2 trial

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    Background: Vulval intraepithelial neoplasia is a skin disorder affecting the vulva that, if left untreated, can become cancerous. Currently, the standard treatment for patients with vulval intraepithelial neoplasia is surgery, but this approach does not guarantee cure and can be disfiguring, causing physical and psychological problems, particularly in women of reproductive age. We aimed to assess the activity, safety, and feasibility of two topical treatments—cidofovir and imiquimod—as an alternative to surgery in female patients with vulval intraepithelial neoplasia.Methods: We recruited female patients (age 16 years or older) from 32 centres to an open-label, randomised, phase 2 trial. Eligibility criteria were biopsy-proven vulval intraepithelial neoplasia grade 3 and at least one lesion that could be measured accurately. We randomly allocated patients to topical treatment with either 1% cidofovir (supplied as a gel in a 10 g tube, to last 6 weeks) or 5% imiquimod (one 250 mg sachet for every application), to be self-applied three times a week for a maximum of 24 weeks. Randomisation (1:1) was done by stratified minimisation via a central computerised system, with stratification by hospital, disease focality, and presentation stage. The primary endpoint was a histologically confirmed complete response at the post-treatment assessment visit 6 weeks after the end of treatment (a maximum of 30 weeks after treatment started). Analysis of the primary endpoint was by intention to treat. Secondary outcomes were toxic effects (to assess safety) and adherence to treatment (to assess feasibility). We present results after all patients had reached the primary endpoint assessment point at 6 weeks; 2-year follow-up of complete responders continues. This trial is registered with Current Controlled Trials, ISRCTN 34420460. Findings: Between Oct 21, 2009, and Jan 11, 2013, 180 participants were enrolled to the study; 89 patients were randomly allocated cidofovir and 91 were assigned imiquimod. At the post-treatment assessment visit, a complete response had been achieved by 41 (46%; 90% CI 37·0–55·3) patients allocated cidofovir and by 42 (46%; 37·2–55·3) patients assigned imiquimod. After 6 weeks of treatment, 156 (87%) patients (78 in each group) had adhered to the treatment regimen. Five patients in the cidofovir group and seven in the imiquimod group either withdrew or were lost to follow-up before the first 6-week safety assessment. Adverse events of grade 3 or higher were reported in 31 (37%) of 84 patients allocated cidofovir and 39 (46%) of 84 patients assigned imiquimod; the most frequent grade 3 and 4 events were pain in the vulva, pruritus, fatigue, and headache. Interpretation: Cidofovir and imiquimod were active, safe, and feasible for treatment of vulval intraepithelial neoplasia and warrant further investigation in a phase 3 setting. Both drugs are effective alternatives to surgery for female patients with vulval intraepithelial neoplasia after exclusion of occult invasive disease

    Viruses in COPD

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    Last writes? The law review in the age of cyberspace

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    This article reassesses the history and future of the law review in light of changing technological and academic conditions. It analyzes why law reviews developed in the late nineteenth and early twentieth centuries, and describes how three different waves of criticism have reflected shifting professorial, professional and pedagogical concerns about the genre. Recent editorial reforms and the inauguration of on-line services and electronic law journals appear to solve some of the law review's traditional problems, but the author suggests that these procedural and technological modifications leave the basic criticisms of the law review system unmet. In this context, the author proposes that legal writers self-publish on the World Wide Web, as he has done in an extended version of the present piece. This strategy would give legal writers more control over the substance and form of their scholarship, would create more opportunities for spontaneity and creativity, and would promote more direct dialogue between legal thinkers

    Inverse PCR

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    Long Distance PCR

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    <i>Candida</i>spp.

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    Blotting Techniques

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    Figure 21 in A salticid archetype for salticid spiders

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    Figure 21. Euchromius ocellea. This cosmopolitan species is apparently migratory, with little variation in appearance between populations (Schouten 1992). Attribution and ©: 1, 4, 20, Chuck Sexton; 2, Ken-ichi Ueda; 3, 21, Monica Krancevic; 5, Diana- Terry Hibbitts; 6-7, Sam Kieschnick; 8, Cosimo Costanzia di Costgliole; 9, 16-17, Jack Cochran; 10, 12, Jon McIntyre; 11, C. McClarren and A. Reago; 13, Justin Williams; 14, Dusty; 15, Gary Nunn; 18, Ellen Hildebrandt; 19, A Rector.Published as part of Hill, David E., 2022, A salticid archetype for salticid spiders, pp. 1-39 in Peckhamia 275 (1) on page 23, DOI: 10.5281/zenodo.717144

    Reassessing Professor Hibbitts\u27s Requiem for Law Reviews

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    The details vary from law review to law review, but typically, an accepted article is edited three times, once for technical compliance with the Bluebook manual of citation, once for substance and clarity, and again by a senior editor. Every citation is checked to confirm that it supports the proposition for which it is offered. The author sees the article at least twice during the process, once after the manuscript has been edited, and again at the galley or page proof stage. Next, the article is typeset (increasingly, this simply means that a word processing file submitted by the author and edited by the law review staff is run through a photo typesetting machine), plates are made, and the volume of the law review containing the article is printed. The law review itself then usually takes care of order fulfillment for subscribers and special orders. Now, consider the typical electronic publishing process on the World Wide Web. This author is familiar with Web-based publishing, having organized and supervised one of the major Web servers on the Internet devoted to legal information. Practices vary from server to server, but the following description is typical. An author, frequently also the owner of a Web page, takes a word processing file of an article, sometimes in the same stage of development that it would be submitted to a law review, sometimes in a much earlier stage of development. He reformats it by hand or by use of macros or scripts to transform word processing formatting codes into html codes. He may also add a hypertext- linked table of contents. The author then places the article on the Web server. There is no acceptance or rejection process, and no third party editing
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