4,860 research outputs found

    Growth plate extracellular matrix defects and short stature in children

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    Many etiological factors causing short stature have already been identified in humans. In the last few years, the advent of new techniques for the detection of chromosomal and molecular abnormalities has made it possible to better identify patients with genetic causes of growth failure. Some of these factors directly affect the development and growth of the skeleton, since they damage the epiphyseal growth plate, where linear growth occurs, influencing chondrogenesis. In particular, defects in genes involved in the organization and function of the growth plate are responsible for several well-known conditions with short stature. These genes play a pivotal role in various mechanisms involving the extracellular matrix, intracellular signaling, paracrine signaling, endocrine signaling, and epigenetic regulation. In this review, we will discuss the genes involved in extracellular matrix disorders. The identification of genetic defects in linear growth failure is important for clinicians and researchers in order to improve the care of children affected by growth disorders

    Is export a probe for domestic production?

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    Recent works leverage export data to assess country production structure and ultimately country relative competitiveness. These works mostly rely only on the exported part of the total country output for reasons of data availability, homogeneity, and quality. Here we use the World Input-Output Database (WIOD), which offers cross-country harmonized data that accounts both for domestic production and export, to investigate to what extent export is a proxy for domestic production. We find that export mirrors remarkably well domestic production for manufacturing sectors or sectors related to physical goods. Conversely, this relation fades away for service related sectors. We found those relations consistently across most of the 40 countries for which data are available

    Broadband stimulated Raman scattering spectroscopy by a photonic time stretcher

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    Stimulated Raman scattering spectroscopy is a powerful technique for label-free molecular identification, but its broadband implementation is technically challenging. We introduce and experimentally demonstrate a novel approach based on photonic time stretch. The broadband femtosecond Stokes pulse, after interacting with the sample, is stretched by a telecom fiber to ≈15ns, mapping its spectrum in time. The signal is sampled through a fast analog-to-digital converter, providing single-shot spectra at 80-kHz rate. We demonstrate ≈10-5 sensitivity over ≈500cm-1 in the C-H region. Our results pave the way to high-speed broadband vibrational imaging for materials science and biophotonics

    Francesco Scorza Barcellona o della passione agiografica

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    L'autrice traccia, sul filo dei ricordi, il profilo scientifico ed umano di Francesco Scorza Barcellona ed introduce gli studi raccolti nel volume.The author traces, on the thread of memories, the scientific and human profile of Francesco Scorza Barcelona and introduces the studies collected in the book
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